FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285404369> ?p ?o ?g. }

• W4285404369 endingPage "100268" @default.
• W4285404369 startingPage "100268" @default.
• W4285404369 abstract "Active mutations in the RAS genes are found in ∼30% of human cancers. Although thought to have overlapping functions, RAS isoforms show preferential activation in human tumors, which prompted us to employ a comparative and quantitative proteomics approach to generate isoform-specific and nucleotide-dependent interactomes of the four RAS isoforms, KRAS4A, KRAS4B, HRAS, and NRAS. Many isoform-specific interacting proteins were identified, including HRAS-specific CARM1 and CHK1 and KRAS-specific PIP4K2C and IPO7. Comparing the interactomes of WT and constitutively active G12D mutant of RAS isoforms, we identified several potential previously unknown effector proteins of RAS, one of which was recently reported while this article was in preparation, RADIL. These interacting proteins play important roles as knockdown or pharmacological inhibition leads to potent inhibition of cancer cells. The HRAS-specific interacting protein CARM1 plays a role in HRAS-induced senescence, with CARM1 knockdown or inhibition selectively increasing senescence in HRAS-transformed cells but not in KRAS4B-transformed cells. By revealing new isoform-specific and nucleotide-dependent RAS interactors, the study here provides insights to help understand the overlapping functions of the RAS isoforms." @default.
• W4285404369 created "2022-07-14" @default.
• W4285404369 creator A5001339258 @default.
• W4285404369 creator A5021906722 @default.
• W4285404369 creator A5052252469 @default.
• W4285404369 creator A5053768809 @default.
• W4285404369 creator A5063880073 @default.
• W4285404369 creator A5090290615 @default.
• W4285404369 creator A5091724734 @default.
• W4285404369 date "2022-08-01" @default.
• W4285404369 modified "2023-09-27" @default.
• W4285404369 title "A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions" @default.
• W4285404369 cites W1989844827 @default.
• W4285404369 cites W1991541438 @default.
• W4285404369 cites W1991953772 @default.
• W4285404369 cites W1992864103 @default.
• W4285404369 cites W1993735775 @default.
• W4285404369 cites W2005189737 @default.
• W4285404369 cites W2007513923 @default.
• W4285404369 cites W2009931781 @default.
• W4285404369 cites W2022433519 @default.
• W4285404369 cites W2025233879 @default.
• W4285404369 cites W2039525991 @default.
• W4285404369 cites W2070210483 @default.
• W4285404369 cites W2075108450 @default.
• W4285404369 cites W2075499588 @default.
• W4285404369 cites W2076324577 @default.
• W4285404369 cites W2079275374 @default.
• W4285404369 cites W2084880905 @default.
• W4285404369 cites W2087404852 @default.
• W4285404369 cites W2096173332 @default.
• W4285404369 cites W2111046889 @default.
• W4285404369 cites W2119095080 @default.
• W4285404369 cites W2127888962 @default.
• W4285404369 cites W2127893574 @default.
• W4285404369 cites W2138498601 @default.
• W4285404369 cites W2140946052 @default.
• W4285404369 cites W2143881980 @default.
• W4285404369 cites W2151366572 @default.
• W4285404369 cites W2152177149 @default.
• W4285404369 cites W2271216541 @default.
• W4285404369 cites W2473904577 @default.
• W4285404369 cites W2526506448 @default.
• W4285404369 cites W2584033231 @default.
• W4285404369 cites W2714738139 @default.
• W4285404369 cites W2759324986 @default.
• W4285404369 cites W2778942333 @default.
• W4285404369 cites W2794191776 @default.
• W4285404369 cites W2890087006 @default.
• W4285404369 cites W2898789672 @default.
• W4285404369 cites W2909177041 @default.
• W4285404369 cites W3123870022 @default.
• W4285404369 cites W3208691473 @default.
• W4285404369 doi "https://doi.org/10.1016/j.mcpro.2022.100268" @default.
• W4285404369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35839996" @default.
• W4285404369 hasPublicationYear "2022" @default.
• W4285404369 type Work @default.
• W4285404369 citedByCount "3" @default.
• W4285404369 countsByYear W42854043692022 @default.
• W4285404369 countsByYear W42854043692023 @default.
• W4285404369 crossrefType "journal-article" @default.
• W4285404369 hasAuthorship W4285404369A5001339258 @default.
• W4285404369 hasAuthorship W4285404369A5021906722 @default.
• W4285404369 hasAuthorship W4285404369A5052252469 @default.
• W4285404369 hasAuthorship W4285404369A5053768809 @default.
• W4285404369 hasAuthorship W4285404369A5063880073 @default.
• W4285404369 hasAuthorship W4285404369A5090290615 @default.
• W4285404369 hasAuthorship W4285404369A5091724734 @default.
• W4285404369 hasBestOaLocation W42854043692 @default.
• W4285404369 hasConcept C104317684 @default.
• W4285404369 hasConcept C1167327 @default.
• W4285404369 hasConcept C173396325 @default.
• W4285404369 hasConcept C21790070 @default.
• W4285404369 hasConcept C2781187634 @default.
• W4285404369 hasConcept C46111723 @default.
• W4285404369 hasConcept C501734568 @default.
• W4285404369 hasConcept C51785407 @default.
• W4285404369 hasConcept C53345823 @default.
• W4285404369 hasConcept C55493867 @default.
• W4285404369 hasConcept C70721500 @default.
• W4285404369 hasConcept C86803240 @default.
• W4285404369 hasConcept C95444343 @default.
• W4285404369 hasConceptScore W4285404369C104317684 @default.
• W4285404369 hasConceptScore W4285404369C1167327 @default.
• W4285404369 hasConceptScore W4285404369C173396325 @default.
• W4285404369 hasConceptScore W4285404369C21790070 @default.
• W4285404369 hasConceptScore W4285404369C2781187634 @default.
• W4285404369 hasConceptScore W4285404369C46111723 @default.
• W4285404369 hasConceptScore W4285404369C501734568 @default.
• W4285404369 hasConceptScore W4285404369C51785407 @default.
• W4285404369 hasConceptScore W4285404369C53345823 @default.
• W4285404369 hasConceptScore W4285404369C55493867 @default.
• W4285404369 hasConceptScore W4285404369C70721500 @default.
• W4285404369 hasConceptScore W4285404369C86803240 @default.
• W4285404369 hasConceptScore W4285404369C95444343 @default.
• W4285404369 hasIssue "8" @default.
• W4285404369 hasLocation W42854043691 @default.
• W4285404369 hasLocation W42854043692 @default.

• next