Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285405108> ?p ?o ?g. }
- W4285405108 endingPage "2951.e19" @default.
- W4285405108 startingPage "2936" @default.
- W4285405108 abstract "We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein269-277 epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A∗02. The Spike P272L mutation that has arisen in at least 112 different SARS-CoV-2 lineages to date, including in lineages classified as variants of concern, was not recognized by the large CD8 T cell response seen across cohorts of HLA A∗02+ convalescent patients and individuals vaccinated against SARS-CoV-2, despite these responses comprising of over 175 different individual T cell receptors. Viral escape at prevalent T cell epitopes restricted by high frequency HLAs may be particularly problematic when vaccine immunity is focused on a single protein such as SARS-CoV-2 Spike, providing a strong argument for inclusion of multiple viral proteins in next generation vaccines and highlighting the need for monitoring T cell escape in new SARS-CoV-2 variants." @default.
- W4285405108 created "2022-07-14" @default.
- W4285405108 creator A5001892176 @default.
- W4285405108 creator A5002053596 @default.
- W4285405108 creator A5008376558 @default.
- W4285405108 creator A5013654674 @default.
- W4285405108 creator A5016732980 @default.
- W4285405108 creator A5016792406 @default.
- W4285405108 creator A5017596912 @default.
- W4285405108 creator A5029474999 @default.
- W4285405108 creator A5032591855 @default.
- W4285405108 creator A5034812246 @default.
- W4285405108 creator A5036444839 @default.
- W4285405108 creator A5039685491 @default.
- W4285405108 creator A5052288243 @default.
- W4285405108 creator A5055475426 @default.
- W4285405108 creator A5057188909 @default.
- W4285405108 creator A5057278336 @default.
- W4285405108 creator A5084136494 @default.
- W4285405108 creator A5089850794 @default.
- W4285405108 date "2022-08-01" @default.
- W4285405108 modified "2023-10-01" @default.
- W4285405108 title "Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope" @default.
- W4285405108 cites W1613936157 @default.
- W4285405108 cites W1617728256 @default.
- W4285405108 cites W1972189965 @default.
- W4285405108 cites W2009596137 @default.
- W4285405108 cites W2049204549 @default.
- W4285405108 cites W2062073809 @default.
- W4285405108 cites W2079504777 @default.
- W4285405108 cites W2080720232 @default.
- W4285405108 cites W2089041106 @default.
- W4285405108 cites W2095983332 @default.
- W4285405108 cites W2108921801 @default.
- W4285405108 cites W2111647009 @default.
- W4285405108 cites W2116117984 @default.
- W4285405108 cites W2119708590 @default.
- W4285405108 cites W2127774996 @default.
- W4285405108 cites W2142215232 @default.
- W4285405108 cites W2144081223 @default.
- W4285405108 cites W2154876959 @default.
- W4285405108 cites W2155740919 @default.
- W4285405108 cites W2159211495 @default.
- W4285405108 cites W2160855984 @default.
- W4285405108 cites W2163341755 @default.
- W4285405108 cites W2430956829 @default.
- W4285405108 cites W2513727910 @default.
- W4285405108 cites W2520973015 @default.
- W4285405108 cites W2752126733 @default.
- W4285405108 cites W2767569203 @default.
- W4285405108 cites W2788334670 @default.
- W4285405108 cites W2807648076 @default.
- W4285405108 cites W2951464304 @default.
- W4285405108 cites W2984055282 @default.
- W4285405108 cites W2990427812 @default.
- W4285405108 cites W3005235420 @default.
- W4285405108 cites W3005830045 @default.
- W4285405108 cites W3009335299 @default.
- W4285405108 cites W3016322638 @default.
- W4285405108 cites W3016673289 @default.
- W4285405108 cites W3022631642 @default.
- W4285405108 cites W3024448878 @default.
- W4285405108 cites W3024643080 @default.
- W4285405108 cites W3025320502 @default.
- W4285405108 cites W3033301286 @default.
- W4285405108 cites W3042183476 @default.
- W4285405108 cites W3043502363 @default.
- W4285405108 cites W3048775784 @default.
- W4285405108 cites W3084879098 @default.
- W4285405108 cites W3087924281 @default.
- W4285405108 cites W3089759643 @default.
- W4285405108 cites W3093768302 @default.
- W4285405108 cites W3093824751 @default.
- W4285405108 cites W3098697637 @default.
- W4285405108 cites W3099293845 @default.
- W4285405108 cites W3103140952 @default.
- W4285405108 cites W3108193091 @default.
- W4285405108 cites W3111255098 @default.
- W4285405108 cites W3111431752 @default.
- W4285405108 cites W3115009914 @default.
- W4285405108 cites W3119321472 @default.
- W4285405108 cites W3119858919 @default.
- W4285405108 cites W3133789246 @default.
- W4285405108 cites W3134643257 @default.
- W4285405108 cites W3135556657 @default.
- W4285405108 cites W3165479483 @default.
- W4285405108 cites W3166766123 @default.
- W4285405108 cites W3170097501 @default.
- W4285405108 cites W3172296615 @default.
- W4285405108 cites W3192126044 @default.
- W4285405108 cites W3199849883 @default.
- W4285405108 cites W3202459547 @default.
- W4285405108 cites W3211023780 @default.
- W4285405108 cites W4206038500 @default.
- W4285405108 cites W4225711802 @default.
- W4285405108 cites W4246271978 @default.
- W4285405108 doi "https://doi.org/10.1016/j.cell.2022.07.002" @default.
- W4285405108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35931021" @default.