Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285405222> ?p ?o ?g. }
- W4285405222 endingPage "173" @default.
- W4285405222 startingPage "163" @default.
- W4285405222 abstract "Chemotherapeutic agents, endocrine therapy and radiotherapy used in the management of breast cancer are known to cause decreased bone mineral density, and thus, increased incidence of fractures. A majority (~60%) of the breast cancer patients in India are either estrogen (ER) or progesterone hormone receptor (PR) positive. Adjuvant treatment with aromatase inhibitors (AIs) is the treatment mainstay for hormone-sensitive disease in postmenopausal (PM) women, with reduced bone mineral density (BMD), which results in increased fracture rates. Zoledronic acid, alendronate, risedronate and denosumab have been the agents of choice for managing bone loss. Denosumab 60 mg is approved for gaining bone mass in women with breast cancer who are at high risk for fracture following adjuvant AI treatment. The phase III HALT-BC data indicate an improvement in BMD with denosumab and a 50% reduction in clinical fractures, with significant improvements seen at the lumbar spine, distal third of the radius, and total hip. Denosumab has several advantages over other bone modifying agents such as subcutaneous self-administration by the patient themselves, no requirement of hospitalization, no dose modifications in renal impairment, and low incidence of acute phase anaphylactic reactions. We review the available evidence of denosumab for managing bone loss in non-metastatic breast cancer patients." @default.
- W4285405222 created "2022-07-14" @default.
- W4285405222 creator A5056234705 @default.
- W4285405222 date "2022-07-01" @default.
- W4285405222 modified "2023-10-01" @default.
- W4285405222 title "Cancer Treatment-Induced Bone Loss: Role of Denosumab in Non-Metastatic Breast Cancer" @default.
- W4285405222 cites W1637200232 @default.
- W4285405222 cites W1761951195 @default.
- W4285405222 cites W1800396987 @default.
- W4285405222 cites W1939805819 @default.
- W4285405222 cites W1955291661 @default.
- W4285405222 cites W1957467225 @default.
- W4285405222 cites W1967385896 @default.
- W4285405222 cites W1980199268 @default.
- W4285405222 cites W1987567308 @default.
- W4285405222 cites W1995867331 @default.
- W4285405222 cites W2005383842 @default.
- W4285405222 cites W2006131871 @default.
- W4285405222 cites W2009361997 @default.
- W4285405222 cites W2010831687 @default.
- W4285405222 cites W2027856259 @default.
- W4285405222 cites W2034606501 @default.
- W4285405222 cites W2038808741 @default.
- W4285405222 cites W2044511370 @default.
- W4285405222 cites W2051399396 @default.
- W4285405222 cites W2054727157 @default.
- W4285405222 cites W2057681998 @default.
- W4285405222 cites W2067686201 @default.
- W4285405222 cites W2068914447 @default.
- W4285405222 cites W2070952404 @default.
- W4285405222 cites W2071655149 @default.
- W4285405222 cites W2081333800 @default.
- W4285405222 cites W2086684921 @default.
- W4285405222 cites W2122786185 @default.
- W4285405222 cites W2127369814 @default.
- W4285405222 cites W2128458647 @default.
- W4285405222 cites W2137411979 @default.
- W4285405222 cites W2139358843 @default.
- W4285405222 cites W2139520218 @default.
- W4285405222 cites W2142338870 @default.
- W4285405222 cites W2143151890 @default.
- W4285405222 cites W2143500476 @default.
- W4285405222 cites W2151447010 @default.
- W4285405222 cites W2160005424 @default.
- W4285405222 cites W2164400719 @default.
- W4285405222 cites W2165011173 @default.
- W4285405222 cites W2169887586 @default.
- W4285405222 cites W2171595133 @default.
- W4285405222 cites W2214665719 @default.
- W4285405222 cites W2254280635 @default.
- W4285405222 cites W2283559195 @default.
- W4285405222 cites W2381569410 @default.
- W4285405222 cites W2382318563 @default.
- W4285405222 cites W2397762359 @default.
- W4285405222 cites W2400762120 @default.
- W4285405222 cites W2407751065 @default.
- W4285405222 cites W2513579707 @default.
- W4285405222 cites W2531973543 @default.
- W4285405222 cites W2589352961 @default.
- W4285405222 cites W2598259575 @default.
- W4285405222 cites W2619448414 @default.
- W4285405222 cites W2743295977 @default.
- W4285405222 cites W2754537450 @default.
- W4285405222 cites W2767592925 @default.
- W4285405222 cites W2792392055 @default.
- W4285405222 cites W2792664125 @default.
- W4285405222 cites W2804329006 @default.
- W4285405222 cites W2816910116 @default.
- W4285405222 cites W2883935206 @default.
- W4285405222 cites W2885173278 @default.
- W4285405222 cites W2887534823 @default.
- W4285405222 cites W2889646458 @default.
- W4285405222 cites W2915626967 @default.
- W4285405222 cites W2925711482 @default.
- W4285405222 cites W2973754763 @default.
- W4285405222 cites W3004790029 @default.
- W4285405222 cites W3009726399 @default.
- W4285405222 cites W3012811675 @default.
- W4285405222 cites W3016905133 @default.
- W4285405222 cites W3048934302 @default.
- W4285405222 cites W4206973824 @default.
- W4285405222 cites W4225574047 @default.
- W4285405222 cites W4252714226 @default.
- W4285405222 cites W1884787461 @default.
- W4285405222 doi "https://doi.org/10.2147/bctt.s353332" @default.
- W4285405222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35860287" @default.
- W4285405222 hasPublicationYear "2022" @default.
- W4285405222 type Work @default.
- W4285405222 citedByCount "4" @default.
- W4285405222 countsByYear W42854052222023 @default.
- W4285405222 crossrefType "journal-article" @default.
- W4285405222 hasAuthorship W4285405222A5056234705 @default.
- W4285405222 hasBestOaLocation W42854052221 @default.
- W4285405222 hasConcept C121608353 @default.
- W4285405222 hasConcept C126322002 @default.
- W4285405222 hasConcept C126894567 @default.
- W4285405222 hasConcept C141071460 @default.
- W4285405222 hasConcept C143998085 @default.