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- W4285405247 endingPage "157313" @default.
- W4285405247 startingPage "157313" @default.
- W4285405247 abstract "As alternatives to perfluorooctanoic acid (PFOA), hexafluoropropylene oxide (HFPO) homologues, including hexafluoropropylene oxide dimer acid (HFPO-DA), hexafluoropropylene oxide trimer acid (HFPO-TA), and hexafluoropropylene oxide tetramer acid (HFPO-TeA), have attracted widespread attention recently due to their environmental ubiquity and high potential for bioaccumulation and toxicity. In the present study, a set of in vivo mouse and in vitro mouse testicular Sertoli TM4 cell experiments were employed to explore the male reproductive toxicity and underlying mechanisms of HFPO homologues on blood-testis barrier. Tissue and permeability analyses of mice testes after 28-day treatment with 5 mg/kg/day HFPO-DA or PFOA, or 0.05 mg/kg/day HFPO-TA or HFPO-TeA indicated that there was an increase in the degradation of TJ protein occludin in mice with a disrupted blood-testis barrier (BTB). Following exposure to 100 μM HFPO-DA, HFPO-TA or 10 μM PFOA, HFPO-TeA, transepithelial electrical resistance measurements of TM4 cells also indicated BTB disruption. Additionally, as a result of the exposure, matrix metalloproteinase-9 expression was enhanced through activation of p38 MAPK, which promoted the degradation of occludin. On the whole, the results indicated HFPO homologues and PFOA induced BTB disruption through upregulation of p-p38/p38 MAPK/MMP-9 pathway, which promoted the degradation of TJ protein occludin and caused the disruption of TJ." @default.
- W4285405247 created "2022-07-14" @default.
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- W4285405247 creator A5066071162 @default.
- W4285405247 date "2022-11-01" @default.
- W4285405247 modified "2023-10-17" @default.
- W4285405247 title "Perfluorooctanoic acid alternatives hexafluoropropylene oxides exert male reproductive toxicity by disrupting blood-testis barrier" @default.
- W4285405247 cites W1142258958 @default.
- W4285405247 cites W1814807853 @default.
- W4285405247 cites W1916521535 @default.
- W4285405247 cites W1964548922 @default.
- W4285405247 cites W1969326789 @default.
- W4285405247 cites W1969835924 @default.
- W4285405247 cites W1972268723 @default.
- W4285405247 cites W1981862111 @default.
- W4285405247 cites W1982171656 @default.
- W4285405247 cites W1983110220 @default.
- W4285405247 cites W1987040388 @default.
- W4285405247 cites W1987338052 @default.
- W4285405247 cites W1989612935 @default.
- W4285405247 cites W1993586084 @default.
- W4285405247 cites W1998402312 @default.
- W4285405247 cites W2000476420 @default.
- W4285405247 cites W2003227605 @default.
- W4285405247 cites W2004469122 @default.
- W4285405247 cites W2005675003 @default.
- W4285405247 cites W2025064470 @default.
- W4285405247 cites W2025634451 @default.
- W4285405247 cites W2028444662 @default.
- W4285405247 cites W2029804435 @default.
- W4285405247 cites W2030560074 @default.
- W4285405247 cites W2031621181 @default.
- W4285405247 cites W2034704736 @default.
- W4285405247 cites W2036747339 @default.
- W4285405247 cites W2038113907 @default.
- W4285405247 cites W2043348153 @default.
- W4285405247 cites W2046488694 @default.
- W4285405247 cites W2050700610 @default.
- W4285405247 cites W2055623806 @default.
- W4285405247 cites W2061401738 @default.
- W4285405247 cites W2064359764 @default.
- W4285405247 cites W2067215286 @default.
- W4285405247 cites W2071359937 @default.
- W4285405247 cites W2072791668 @default.
- W4285405247 cites W2078282082 @default.
- W4285405247 cites W2079744842 @default.
- W4285405247 cites W2081318196 @default.
- W4285405247 cites W2085414996 @default.
- W4285405247 cites W2086492898 @default.
- W4285405247 cites W2087181963 @default.
- W4285405247 cites W2102388558 @default.
- W4285405247 cites W2112558380 @default.
- W4285405247 cites W2115272499 @default.
- W4285405247 cites W2125775820 @default.
- W4285405247 cites W2126381611 @default.
- W4285405247 cites W2134776160 @default.
- W4285405247 cites W2151396872 @default.
- W4285405247 cites W2154401382 @default.
- W4285405247 cites W2160173730 @default.
- W4285405247 cites W2222179224 @default.
- W4285405247 cites W2283065739 @default.
- W4285405247 cites W2295428010 @default.
- W4285405247 cites W2318114413 @default.
- W4285405247 cites W2326426016 @default.
- W4285405247 cites W2339405894 @default.
- W4285405247 cites W2409075100 @default.
- W4285405247 cites W2548615408 @default.
- W4285405247 cites W2556805998 @default.
- W4285405247 cites W2562474273 @default.
- W4285405247 cites W2741446350 @default.
- W4285405247 cites W2744815276 @default.
- W4285405247 cites W2766630191 @default.
- W4285405247 cites W2766802654 @default.
- W4285405247 cites W2789745773 @default.
- W4285405247 cites W2801936321 @default.
- W4285405247 cites W2805048380 @default.
- W4285405247 cites W2809368137 @default.
- W4285405247 cites W2811179687 @default.
- W4285405247 cites W2885583224 @default.
- W4285405247 cites W2910128258 @default.
- W4285405247 cites W2917598327 @default.
- W4285405247 cites W2921945250 @default.
- W4285405247 cites W2953153423 @default.
- W4285405247 cites W2963297172 @default.
- W4285405247 cites W3006460280 @default.
- W4285405247 cites W3011922328 @default.
- W4285405247 cites W3013542392 @default.
- W4285405247 cites W3092235955 @default.
- W4285405247 cites W4206305663 @default.
- W4285405247 cites W4210634254 @default.
- W4285405247 cites W4210935735 @default.
- W4285405247 cites W4243002209 @default.