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- W4285405253 abstract "Genetic attributions for age of onset have been investigated for multiple entities ( Blauwendraat et al., 2019 Blauwendraat C. Heilbron K. Vallerga C.L. Bandres-Ciga S. von Coelln R. Pihlstrøm L. et al. Parkinson's disease age at onset genome-wide association study: defining heritability, genetic loci, and alpha-synuclein mechanisms. Mov Disord. 2019; 34: 866-875 Crossref PubMed Scopus (169) Google Scholar ; Kamboh et al., 2012 Kamboh M.I. Barmada M.M. Demirci F.Y. Minster R.L. Carrasquillo M.M. Pankratz V.S. et al. Genome-wide association analysis of age-at-onset in Alzheimer's disease. Mol Psychiatry. 2012; 17: 1340-1346 Crossref PubMed Scopus (73) Google Scholar ; Power et al., 2017 Power R.A. Tansey K.E. Buttenschøn H.N. Cohen-Woods S. Bigdeli T. Hall L.S. et al. Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biol Psychiatry. 2017; 81: 325-335 Abstract Full Text Full Text PDF PubMed Scopus (135) Google Scholar ; Woolston et al., 2017 Woolston A.L. Hsiao P.C. Kuo P.H. Wang S.H. Lien Y.J. Liu C.M. et al. Genetic loci associated with an earlier age at onset in multiplex schizophrenia. Sci Rep. 2017; 7: 6486 Crossref PubMed Scopus (8) Google Scholar ), but evidence is still lacking in allergic diseases. Wan et al., 2017 Wan J. Mitra N. Hoffstad O.J. Margolis D.J. Influence of FLG mutations and TSLP polymorphisms on atopic dermatitis onset age. Ann Allergy Asthma Immunol. 2017; 118: 737-738.e1 Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar found that FLG mutations are associated with earlier atopic dermatitis (AD) onset. Ferreira et al., 2020 Ferreira M.A.R. Vonk J.M. Baurecht H. Marenholz I. Tian C. Hoffman J.D. et al. Age-of-onset information helps identify 76 genetic variants associated with allergic disease. PLoS Genet. 2020; 16e1008725 Crossref Scopus (14) Google Scholar performed a GWAS for allergic diseases, including AD, supporting the notion of strong genetic effects on early- and late-onset AD. These are the only studies that have investigated the genetic associations in age of onset for AD and were limited to predominantly European populations. Thus, unraveling the component of age of onset at a genome-wide level for patients with AD in Asian populations would add important insights. Recently, we, to our knowledge, reported previously unreported loci, including Japanese-specific loci, through one of the largest GWAS for AD ( Tanaka et al., 2021 Tanaka N. Koido M. Suzuki A. Otomo N. Suetsugu H. Kochi Y. et al. Eight novel susceptibility loci and putative causal variants in atopic dermatitis. J Allergy Clin Immunol. 2021; 148: 1293-1306 Abstract Full Text Full Text PDF PubMed Google Scholar ). Taking advantage of the GWAS results, we investigated further the genetic architectures of AD, underlying the age of onset of AD." @default.
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- W4285405253 date "2022-12-01" @default.
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- W4285405253 title "Genetic Architectures Underlie Onset Age of Atopic Dermatitis" @default.
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- W4285405253 doi "https://doi.org/10.1016/j.jid.2022.06.010" @default.
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