FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285411682> ?p ?o ?g. }

• W4285411682 endingPage "103115" @default.
• W4285411682 startingPage "103115" @default.
• W4285411682 abstract "Improving brain insulin sensitivity may be a promising approach in the prevention and treatment of metabolic and cognitive diseases. Our aim was to investigate acute effects of inorganic nitrate on regional cerebral blood flow (CBF) responses to intranasal insulin in abdominally obese men.Eighteen apparently healthy men, aged 18-60 years and with a waist circumference ≥ 102 cm, participated in a randomized, double-blind, placebo-controlled cross-over trial. The study consisted of two test days separated by at least one week. Men received in random order a drink providing 10 mmol (i.e., 625 mg nitrate) potassium nitrate or an isomolar placebo drink with potassium chloride. Brain insulin action was assessed 120-150 min after the drinks by quantifying acute effects of nasal insulin on regional CBF using arterial spin labeling Magnetic Resonance Imaging. Glucose and insulin concentrations were measured at regular intervals, while blood pressure was determined fasted and at 240 min.Inorganic nitrate intake increased regional insulin action in five brain clusters. The two largest clusters were located in the right temporal lobe (ΔCBF: 7.0 ± 3.8 mL/100 g/min, volume: 5296 mm3, P < 0.001; and ΔCBF: 6.5 ± 4.3 mL/100 g/min, volume: 3592 mm3, P < 0.001), while two other cortical clusters were part of the right frontal (ΔCBF: 9.0 ± 6.0 mL/100 g/min, volume: 1096 mm3, P = 0.007) and the left parietal lobe (ΔCBF: 6.1 ± 4.3 mL/100 g/min, volume: 1024 mm3, P = 0.012). One subcortical cluster was located in the striatum (ΔCBF: 5.9 ± 3.2 mL/100 g/min, volume: 1792 mm3, P < 0.001). No effects of nitrate were observed on CBF before administration. Following nitrate intake, circulating nitrate plus nitrite concentrations increased over time (P = 0.003), but insulin and glucose concentrations and blood pressure did not change.Acute inorganic nitrate intake may improve regional brain insulin action in abdominally obese men. These regions are involved in the regulation of different metabolic and cognitive processes. The trial was registered on January 6th, 2021 at ClinicalTrials.gov as NCT04700241." @default.
• W4285411682 created "2022-07-14" @default.
• W4285411682 creator A5004148771 @default.
• W4285411682 creator A5006945105 @default.
• W4285411682 creator A5052341425 @default.
• W4285411682 creator A5071317424 @default.
• W4285411682 creator A5086258416 @default.
• W4285411682 date "2022-01-01" @default.
• W4285411682 modified "2023-09-26" @default.
• W4285411682 title "Acute inorganic nitrate intake increases regional insulin action in the brain: Results of a double-blind, randomized, controlled cross-over trial with abdominally obese men" @default.
• W4285411682 cites W1834081378 @default.
• W4285411682 cites W1931799715 @default.
• W4285411682 cites W1983339208 @default.
• W4285411682 cites W1996857113 @default.
• W4285411682 cites W1996941873 @default.
• W4285411682 cites W1998899408 @default.
• W4285411682 cites W2011872130 @default.
• W4285411682 cites W2017602185 @default.
• W4285411682 cites W2053859901 @default.
• W4285411682 cites W2066752219 @default.
• W4285411682 cites W2070949043 @default.
• W4285411682 cites W2072888264 @default.
• W4285411682 cites W2093972428 @default.
• W4285411682 cites W2114918553 @default.
• W4285411682 cites W2116404316 @default.
• W4285411682 cites W2116641010 @default.
• W4285411682 cites W2117740211 @default.
• W4285411682 cites W2124864609 @default.
• W4285411682 cites W2133002147 @default.
• W4285411682 cites W2142970408 @default.
• W4285411682 cites W2143535162 @default.
• W4285411682 cites W2160234571 @default.
• W4285411682 cites W2163177724 @default.
• W4285411682 cites W2164981686 @default.
• W4285411682 cites W2167234030 @default.
• W4285411682 cites W2167525293 @default.
• W4285411682 cites W2170596893 @default.
• W4285411682 cites W2189133141 @default.
• W4285411682 cites W2324392087 @default.
• W4285411682 cites W2476839077 @default.
• W4285411682 cites W2492656860 @default.
• W4285411682 cites W2497601590 @default.
• W4285411682 cites W2501817046 @default.
• W4285411682 cites W2566533773 @default.
• W4285411682 cites W2586809204 @default.
• W4285411682 cites W2602081862 @default.
• W4285411682 cites W260652415 @default.
• W4285411682 cites W2607031541 @default.
• W4285411682 cites W2614768217 @default.
• W4285411682 cites W2692655360 @default.
• W4285411682 cites W2761157994 @default.
• W4285411682 cites W2766902973 @default.
• W4285411682 cites W2786962139 @default.
• W4285411682 cites W2794409385 @default.
• W4285411682 cites W2801876116 @default.
• W4285411682 cites W2920258695 @default.
• W4285411682 cites W2986102572 @default.
• W4285411682 cites W2990507658 @default.
• W4285411682 cites W3004699003 @default.
• W4285411682 cites W3017215630 @default.
• W4285411682 cites W3027292275 @default.
• W4285411682 cites W3170389531 @default.
• W4285411682 cites W3210195064 @default.
• W4285411682 cites W633670822 @default.
• W4285411682 doi "https://doi.org/10.1016/j.nicl.2022.103115" @default.
• W4285411682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35843050" @default.
• W4285411682 hasPublicationYear "2022" @default.
• W4285411682 type Work @default.
• W4285411682 citedByCount "1" @default.
• W4285411682 countsByYear W42854116822022 @default.
• W4285411682 crossrefType "journal-article" @default.
• W4285411682 hasAuthorship W4285411682A5004148771 @default.
• W4285411682 hasAuthorship W4285411682A5006945105 @default.
• W4285411682 hasAuthorship W4285411682A5052341425 @default.
• W4285411682 hasAuthorship W4285411682A5071317424 @default.
• W4285411682 hasAuthorship W4285411682A5086258416 @default.
• W4285411682 hasBestOaLocation W42854116821 @default.
• W4285411682 hasConcept C126322002 @default.
• W4285411682 hasConcept C134018914 @default.
• W4285411682 hasConcept C142724271 @default.
• W4285411682 hasConcept C157767197 @default.
• W4285411682 hasConcept C204787440 @default.
• W4285411682 hasConcept C27081682 @default.
• W4285411682 hasConcept C2776193436 @default.
• W4285411682 hasConcept C2779306644 @default.
• W4285411682 hasConcept C42219234 @default.
• W4285411682 hasConcept C511355011 @default.
• W4285411682 hasConcept C71924100 @default.
• W4285411682 hasConcept C84393581 @default.
• W4285411682 hasConcept C87813604 @default.
• W4285411682 hasConceptScore W4285411682C126322002 @default.
• W4285411682 hasConceptScore W4285411682C134018914 @default.
• W4285411682 hasConceptScore W4285411682C142724271 @default.
• W4285411682 hasConceptScore W4285411682C157767197 @default.
• W4285411682 hasConceptScore W4285411682C204787440 @default.
• W4285411682 hasConceptScore W4285411682C27081682 @default.
• W4285411682 hasConceptScore W4285411682C2776193436 @default.
• W4285411682 hasConceptScore W4285411682C2779306644 @default.

• next