Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285486194> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4285486194 abstract "Urinary chloride (Cl) is the key electrolyte for regulating renin secretion at the macula densa under the ‘tubulo-glomerular feedback’. Whether or not Cl filtrated into the urinary tubules actually associates with plasma renin activity (PRA) in clinical heart failure (HF) remains unclear. Data from 29 patients with acute worsening HF (48% men; 80.3±12 years) were analyzed. Blood and urine samples were immediately obtained before decongestive therapy after the patients rested in a supine position for 20-min. Clinical tests included peripheral blood tests, serum and spot urinary electrolytes, b-type natriuretic peptide (BNP), plasma neurohormones, and fractional urinary electrolyte excretion. In the 29 patients, urinary Cl concentrations inversely correlated with logarithmically transformed PRA (R2 =0.41, p=0.0002). The correlation was weaker in worsening chronic HF patients (R2 =0.32, p=0.01) compared with de novo HF patients (R2 =0.70, p=0.0026). Patients were divided into 2 groups according to the median urinary Cl concentration, a low group and a high group. Compared with the high group (100~184 mEq/L; n=14), the low group (4~95 mEq/L; n=15) exhibited more renal (serum creatinine; 1.45±0.63 vs 1.00±0.38 mg/d, p=0.029) and cardiac (log BNP; 2.99±0.3 vs 2.66±0.32 pg/mL, p=0.008 p=0.008) impairment, and higher PRA (3.42±4.7 vs 0.73±0.46 ng/mL/h, p=0.049), and lower fractional excretion of urinary Cl (1.34±1.3 vs 5.33±4.1%, p<0.0001). The present study provides clinical data on the possible functioning of urinary Cl involved in the mechanism of ‘tubulo-glomerular feedback’, and thus advances our understanding of the clinical meanings of the significance of urinary Cl concentration measurement." @default.
- W4285486194 created "2022-07-15" @default.
- W4285486194 date "2021-02-22" @default.
- W4285486194 modified "2023-09-27" @default.
- W4285486194 title "Clinical Significance of Spot Urinary Chloride Concentration Measurements in Patients with Acute Heart Failure: Investigation on the Basis of the ‘TubuloGlomerular Feedback’ Mechanism" @default.
- W4285486194 doi "https://doi.org/10.33140/coa.06.01.004" @default.
- W4285486194 hasPublicationYear "2021" @default.
- W4285486194 type Work @default.
- W4285486194 citedByCount "0" @default.
- W4285486194 crossrefType "journal-article" @default.
- W4285486194 hasBestOaLocation W42854861941 @default.
- W4285486194 hasConcept C10146269 @default.
- W4285486194 hasConcept C125567185 @default.
- W4285486194 hasConcept C126322002 @default.
- W4285486194 hasConcept C126894567 @default.
- W4285486194 hasConcept C134018914 @default.
- W4285486194 hasConcept C138976137 @default.
- W4285486194 hasConcept C159641895 @default.
- W4285486194 hasConcept C185592680 @default.
- W4285486194 hasConcept C198710026 @default.
- W4285486194 hasConcept C2778198053 @default.
- W4285486194 hasConcept C2780026642 @default.
- W4285486194 hasConcept C2780306776 @default.
- W4285486194 hasConcept C2781236342 @default.
- W4285486194 hasConcept C71924100 @default.
- W4285486194 hasConcept C7643261 @default.
- W4285486194 hasConcept C77411442 @default.
- W4285486194 hasConcept C84393581 @default.
- W4285486194 hasConceptScore W4285486194C10146269 @default.
- W4285486194 hasConceptScore W4285486194C125567185 @default.
- W4285486194 hasConceptScore W4285486194C126322002 @default.
- W4285486194 hasConceptScore W4285486194C126894567 @default.
- W4285486194 hasConceptScore W4285486194C134018914 @default.
- W4285486194 hasConceptScore W4285486194C138976137 @default.
- W4285486194 hasConceptScore W4285486194C159641895 @default.
- W4285486194 hasConceptScore W4285486194C185592680 @default.
- W4285486194 hasConceptScore W4285486194C198710026 @default.
- W4285486194 hasConceptScore W4285486194C2778198053 @default.
- W4285486194 hasConceptScore W4285486194C2780026642 @default.
- W4285486194 hasConceptScore W4285486194C2780306776 @default.
- W4285486194 hasConceptScore W4285486194C2781236342 @default.
- W4285486194 hasConceptScore W4285486194C71924100 @default.
- W4285486194 hasConceptScore W4285486194C7643261 @default.
- W4285486194 hasConceptScore W4285486194C77411442 @default.
- W4285486194 hasConceptScore W4285486194C84393581 @default.
- W4285486194 hasIssue "1" @default.
- W4285486194 hasLocation W42854861941 @default.
- W4285486194 hasOpenAccess W4285486194 @default.
- W4285486194 hasPrimaryLocation W42854861941 @default.
- W4285486194 hasRelatedWork W1969858557 @default.
- W4285486194 hasRelatedWork W1977123261 @default.
- W4285486194 hasRelatedWork W2044747643 @default.
- W4285486194 hasRelatedWork W2047608102 @default.
- W4285486194 hasRelatedWork W2077998387 @default.
- W4285486194 hasRelatedWork W2079602738 @default.
- W4285486194 hasRelatedWork W2080723551 @default.
- W4285486194 hasRelatedWork W2088924510 @default.
- W4285486194 hasRelatedWork W2104573868 @default.
- W4285486194 hasRelatedWork W2081968899 @default.
- W4285486194 hasVolume "6" @default.
- W4285486194 isParatext "false" @default.
- W4285486194 isRetracted "false" @default.
- W4285486194 workType "article" @default.