Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285490690> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4285490690 abstract "Background and Purpose: A 10 hospital regional network transitioned to tenecteplase as the standard of care stroke thrombolytic in September 2019 because of its workflow advantages and reported non-inferior clinical outcomes relative to alteplase in meta-analyses of randomized trials. We assessed whether tenecteplase use in routine clinical practice reduces thrombolytic workflow times with noninferior clinical outcomes. Methods We designed a prospective registry based observational, sequential cohort comparison tenecteplase (n=234) to alteplase (n=354) treated stroke patients. We hypothesized: (1) an increase in the proportion of patients meeting target times for target door to needle (DTN) and transfer door in door out (DIDO), and (2) non inferior favorable (discharge to home with independent ambulation) and unfavorable (symptomatic intracranial hemorrhage, in-hospital mortality or discharge to hospice) in the tenecteplase group. Total hospital cost associated with each treatment was also compared. Results: Target DTN within 45 minutes was superior for tenecteplase, 41% versus 29%; aOR 1.76 (95% CI 1.24, 2.52), P = 0.002. Target DIDO within 90 minutes was superior for tenecteplase 37% (15/43) versus 14% (9/65); OR 3.69 (95% CI 1.47, 9.7), P =0.006, overall, and 67% (12/18) versus 14% (2/14) for those transferred for thrombectomy after thrombolytic treatment (P=0.009). Favorable outcome for tenecteplase fell within the 6.5% non-inferiority margin; aOR 1.28 (95% CI 0.92, 1.77). Unfavorable outcome was less for tenecteplase 7.7% versus 11.9%, aOR 0.79 (95% CI 0.46, 1.32), but did not fall within the pre-specified 1% non-inferior boundary. Net benefit (%favorable minus %unfavorable) was greater for the tenecteplase sample: 36% v 27%. P=0.022. Median cost per hospital encounter was less for tenecteplase cases ($13,382 vs $15,841; P <0.001). Conclusions: Switching to tenecteplase in routine clinical practice in a 10 hospital network was associated with shorter DTN and DIDO times, non-inferior favorable clinical outcomes at discharge, and reduced hospital costs. Evaluation in larger, multicenter cohorts is recommended to determine if these observations generalize." @default.
- W4285490690 created "2022-07-15" @default.
- W4285490690 creator A5001158821 @default.
- W4285490690 creator A5005070119 @default.
- W4285490690 creator A5007208025 @default.
- W4285490690 creator A5013270602 @default.
- W4285490690 creator A5016879654 @default.
- W4285490690 creator A5025216050 @default.
- W4285490690 creator A5025773385 @default.
- W4285490690 creator A5026455821 @default.
- W4285490690 creator A5026768310 @default.
- W4285490690 creator A5030598264 @default.
- W4285490690 creator A5032825188 @default.
- W4285490690 creator A5035593642 @default.
- W4285490690 creator A5041507960 @default.
- W4285490690 creator A5044817973 @default.
- W4285490690 creator A5052793763 @default.
- W4285490690 creator A5053512921 @default.
- W4285490690 creator A5067509508 @default.
- W4285490690 creator A5069989341 @default.
- W4285490690 creator A5073573611 @default.
- W4285490690 creator A5074707631 @default.
- W4285490690 creator A5077559147 @default.
- W4285490690 creator A5078213133 @default.
- W4285490690 creator A5080702509 @default.
- W4285490690 date "2022-07-15" @default.
- W4285490690 modified "2023-10-16" @default.
- W4285490690 title "Prospective Observational Cohort Study Of Tenecteplase Versus Alteplase In Routine Clinical Practice" @default.
- W4285490690 doi "https://doi.org/10.1101/2022.07.12.22277564" @default.
- W4285490690 hasPublicationYear "2022" @default.
- W4285490690 type Work @default.
- W4285490690 citedByCount "0" @default.
- W4285490690 crossrefType "posted-content" @default.
- W4285490690 hasAuthorship W4285490690A5001158821 @default.
- W4285490690 hasAuthorship W4285490690A5005070119 @default.
- W4285490690 hasAuthorship W4285490690A5007208025 @default.
- W4285490690 hasAuthorship W4285490690A5013270602 @default.
- W4285490690 hasAuthorship W4285490690A5016879654 @default.
- W4285490690 hasAuthorship W4285490690A5025216050 @default.
- W4285490690 hasAuthorship W4285490690A5025773385 @default.
- W4285490690 hasAuthorship W4285490690A5026455821 @default.
- W4285490690 hasAuthorship W4285490690A5026768310 @default.
- W4285490690 hasAuthorship W4285490690A5030598264 @default.
- W4285490690 hasAuthorship W4285490690A5032825188 @default.
- W4285490690 hasAuthorship W4285490690A5035593642 @default.
- W4285490690 hasAuthorship W4285490690A5041507960 @default.
- W4285490690 hasAuthorship W4285490690A5044817973 @default.
- W4285490690 hasAuthorship W4285490690A5052793763 @default.
- W4285490690 hasAuthorship W4285490690A5053512921 @default.
- W4285490690 hasAuthorship W4285490690A5067509508 @default.
- W4285490690 hasAuthorship W4285490690A5069989341 @default.
- W4285490690 hasAuthorship W4285490690A5073573611 @default.
- W4285490690 hasAuthorship W4285490690A5074707631 @default.
- W4285490690 hasAuthorship W4285490690A5077559147 @default.
- W4285490690 hasAuthorship W4285490690A5078213133 @default.
- W4285490690 hasAuthorship W4285490690A5080702509 @default.
- W4285490690 hasBestOaLocation W42854906901 @default.
- W4285490690 hasConcept C126322002 @default.
- W4285490690 hasConcept C127413603 @default.
- W4285490690 hasConcept C17923572 @default.
- W4285490690 hasConcept C194828623 @default.
- W4285490690 hasConcept C23131810 @default.
- W4285490690 hasConcept C2776572282 @default.
- W4285490690 hasConcept C2779095551 @default.
- W4285490690 hasConcept C2779581417 @default.
- W4285490690 hasConcept C2780645631 @default.
- W4285490690 hasConcept C2909817843 @default.
- W4285490690 hasConcept C500558357 @default.
- W4285490690 hasConcept C71924100 @default.
- W4285490690 hasConcept C78519656 @default.
- W4285490690 hasConceptScore W4285490690C126322002 @default.
- W4285490690 hasConceptScore W4285490690C127413603 @default.
- W4285490690 hasConceptScore W4285490690C17923572 @default.
- W4285490690 hasConceptScore W4285490690C194828623 @default.
- W4285490690 hasConceptScore W4285490690C23131810 @default.
- W4285490690 hasConceptScore W4285490690C2776572282 @default.
- W4285490690 hasConceptScore W4285490690C2779095551 @default.
- W4285490690 hasConceptScore W4285490690C2779581417 @default.
- W4285490690 hasConceptScore W4285490690C2780645631 @default.
- W4285490690 hasConceptScore W4285490690C2909817843 @default.
- W4285490690 hasConceptScore W4285490690C500558357 @default.
- W4285490690 hasConceptScore W4285490690C71924100 @default.
- W4285490690 hasConceptScore W4285490690C78519656 @default.
- W4285490690 hasLocation W42854906901 @default.
- W4285490690 hasOpenAccess W4285490690 @default.
- W4285490690 hasPrimaryLocation W42854906901 @default.
- W4285490690 hasRelatedWork W1970658819 @default.
- W4285490690 hasRelatedWork W2022175645 @default.
- W4285490690 hasRelatedWork W2077583655 @default.
- W4285490690 hasRelatedWork W2112328442 @default.
- W4285490690 hasRelatedWork W2258788090 @default.
- W4285490690 hasRelatedWork W246626156 @default.
- W4285490690 hasRelatedWork W3112097368 @default.
- W4285490690 hasRelatedWork W3177981495 @default.
- W4285490690 hasRelatedWork W4210744081 @default.
- W4285490690 hasRelatedWork W4376286345 @default.
- W4285490690 isParatext "false" @default.
- W4285490690 isRetracted "false" @default.
- W4285490690 workType "article" @default.