Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285491569> ?p ?o ?g. }
- W4285491569 endingPage "2734" @default.
- W4285491569 startingPage "2716" @default.
- W4285491569 abstract "Precision medicine has become a dominant theme in the treatment of biliary tract cancers (BTCs). Although prognosis remains poor, technologies for improved molecular characterization along with the US Food and Drug Administration approval of several targeted therapies have changed the therapeutic landscape of advanced BTC. The hallmark of BTC oncogenesis is chronic inflammation of the liver and biliary tract regardless of the anatomical subtype. Subtypes of BTC correspond to distinct molecular characteristics, making BTC a molecularly heterogenous collection of tumors. Collectively, up to 40% of BTCs harbor a potentially targetable molecular abnormality, and the National Comprehensive Cancer Network guidelines recommend molecular profiling for all patients with advanced BTC. Use of circulating tumor DNA, immunohistochemistry, and next-generation sequencing continues to expand the utility for biomarker-driven management and molecular monitoring of BTC. Improving outcomes using biomarker-agnostic treatment for nontargetable tumors also remains a priority, and combinational treatment strategies such as immune checkpoint inhibition plus chemotherapy hold promise for this subgroup of patients." @default.
- W4285491569 created "2022-07-15" @default.
- W4285491569 creator A5007073068 @default.
- W4285491569 creator A5012936802 @default.
- W4285491569 creator A5025510544 @default.
- W4285491569 date "2022-08-20" @default.
- W4285491569 modified "2023-10-01" @default.
- W4285491569 title "Precision Medicine in Biliary Tract Cancer" @default.
- W4285491569 cites W1846586690 @default.
- W4285491569 cites W1903979702 @default.
- W4285491569 cites W1960850967 @default.
- W4285491569 cites W1979728979 @default.
- W4285491569 cites W1999916185 @default.
- W4285491569 cites W2007086626 @default.
- W4285491569 cites W2007555374 @default.
- W4285491569 cites W2015277548 @default.
- W4285491569 cites W2025130792 @default.
- W4285491569 cites W2033522521 @default.
- W4285491569 cites W2051404522 @default.
- W4285491569 cites W2073988279 @default.
- W4285491569 cites W2075957912 @default.
- W4285491569 cites W2095046027 @default.
- W4285491569 cites W2096796171 @default.
- W4285491569 cites W2115261608 @default.
- W4285491569 cites W2139046059 @default.
- W4285491569 cites W2139960280 @default.
- W4285491569 cites W2146903154 @default.
- W4285491569 cites W2184754905 @default.
- W4285491569 cites W2520639290 @default.
- W4285491569 cites W2547705653 @default.
- W4285491569 cites W2589651021 @default.
- W4285491569 cites W2603204749 @default.
- W4285491569 cites W2745824859 @default.
- W4285491569 cites W2769404118 @default.
- W4285491569 cites W2790254562 @default.
- W4285491569 cites W2796947832 @default.
- W4285491569 cites W2797266541 @default.
- W4285491569 cites W2799606914 @default.
- W4285491569 cites W2805926640 @default.
- W4285491569 cites W2809966743 @default.
- W4285491569 cites W2903799300 @default.
- W4285491569 cites W2903993960 @default.
- W4285491569 cites W2912915787 @default.
- W4285491569 cites W2920983014 @default.
- W4285491569 cites W2937317161 @default.
- W4285491569 cites W2947109943 @default.
- W4285491569 cites W2984359187 @default.
- W4285491569 cites W2996574710 @default.
- W4285491569 cites W2997215171 @default.
- W4285491569 cites W3010944770 @default.
- W4285491569 cites W3021696184 @default.
- W4285491569 cites W3024247862 @default.
- W4285491569 cites W3029098519 @default.
- W4285491569 cites W3031031837 @default.
- W4285491569 cites W3031054651 @default.
- W4285491569 cites W3039360174 @default.
- W4285491569 cites W3049104202 @default.
- W4285491569 cites W3088769124 @default.
- W4285491569 cites W3089208853 @default.
- W4285491569 cites W3109369918 @default.
- W4285491569 cites W3122499681 @default.
- W4285491569 cites W3124058635 @default.
- W4285491569 cites W3124129499 @default.
- W4285491569 cites W3125020465 @default.
- W4285491569 cites W3133939649 @default.
- W4285491569 cites W3134430032 @default.
- W4285491569 cites W3134481517 @default.
- W4285491569 cites W3165923252 @default.
- W4285491569 cites W3169081264 @default.
- W4285491569 cites W3172457245 @default.
- W4285491569 cites W3192574431 @default.
- W4285491569 cites W3193026281 @default.
- W4285491569 cites W3199253355 @default.
- W4285491569 cites W3200481426 @default.
- W4285491569 cites W3205618463 @default.
- W4285491569 cites W3206989574 @default.
- W4285491569 cites W4206152557 @default.
- W4285491569 cites W4225673512 @default.
- W4285491569 doi "https://doi.org/10.1200/jco.21.02576" @default.
- W4285491569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35839428" @default.
- W4285491569 hasPublicationYear "2022" @default.
- W4285491569 type Work @default.
- W4285491569 citedByCount "10" @default.
- W4285491569 countsByYear W42854915692022 @default.
- W4285491569 countsByYear W42854915692023 @default.
- W4285491569 crossrefType "journal-article" @default.
- W4285491569 hasAuthorship W4285491569A5007073068 @default.
- W4285491569 hasAuthorship W4285491569A5012936802 @default.
- W4285491569 hasAuthorship W4285491569A5025510544 @default.
- W4285491569 hasConcept C121608353 @default.
- W4285491569 hasConcept C126322002 @default.
- W4285491569 hasConcept C142724271 @default.
- W4285491569 hasConcept C143998085 @default.
- W4285491569 hasConcept C163763905 @default.
- W4285491569 hasConcept C185592680 @default.
- W4285491569 hasConcept C2775982439 @default.
- W4285491569 hasConcept C2780258809 @default.
- W4285491569 hasConcept C2781197716 @default.