FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285492081> ?p ?o ?g. }

• W4285492081 abstract "Abstract Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells that proliferate in the bone marrow. miRNAs are promising biomarkers for risk stratification in MM and several miRNAs are shown to have a function in disease pathogenesis. However, to date, surprisingly few miRNA-mRNA interactions have been described for and functionally validated in MM. In this study, we performed miRNA-seq and mRNA-seq on CD138 + cells isolated from bone marrow aspirates of 86 MM patients to identify novel interactions between sRNAs and mRNAs. We detected 9.8% significantly correlated miRNA-mRNA pairs of which 5.17% were positively correlated and 4.65% were negatively correlated. We found that miRNA-mRNA pairs that were predicted by in silico target-prediction algorithms were more negatively correlated than non-target pairs, indicating functional miRNA targeting and that correlation between miRNAs and mRNAs from patients can be used to identify miRNA-targets. mRNAs for negatively correlated miRNA-mRNA target pairs were associated with gene ontology terms such as autophagy, protein degradation and endoplasmic stress response, reflecting important processes in MM. Targets for two specific miRNAs, miR-125b-5p and miR-365b-3p, were functionally validated in MM cell line transfection experiments followed by RNA-sequencing and qPCR. In summary, we identified functional miRNA-mRNA target pairs by correlating miRNA and mRNA data from primary MM cells. We identified several target pairs that are of potential interest for further studies. The data presented here may serve as a hypothesis-generating knowledge base for other researchers in the miRNA/MM field. We also provide an interactive web application that can be used to exploit the miRNA-target interactions as well as clinical parameters associated to these target-pairs." @default.
• W4285492081 created "2022-07-15" @default.
• W4285492081 creator A5008003184 @default.
• W4285492081 creator A5015302194 @default.
• W4285492081 creator A5025598471 @default.
• W4285492081 creator A5036089972 @default.
• W4285492081 creator A5046489406 @default.
• W4285492081 creator A5070319781 @default.
• W4285492081 creator A5071862673 @default.
• W4285492081 creator A5083868539 @default.
• W4285492081 date "2022-07-15" @default.
• W4285492081 modified "2023-09-30" @default.
• W4285492081 title "Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma" @default.
• W4285492081 cites W144423133 @default.
• W4285492081 cites W1502976376 @default.
• W4285492081 cites W1964662391 @default.
• W4285492081 cites W1990868443 @default.
• W4285492081 cites W2020469175 @default.
• W4285492081 cites W2026570544 @default.
• W4285492081 cites W2026642838 @default.
• W4285492081 cites W2030806318 @default.
• W4285492081 cites W2042748226 @default.
• W4285492081 cites W2049702532 @default.
• W4285492081 cites W2053304186 @default.
• W4285492081 cites W2063762431 @default.
• W4285492081 cites W2069771703 @default.
• W4285492081 cites W2083381199 @default.
• W4285492081 cites W2090260733 @default.
• W4285492081 cites W2104916907 @default.
• W4285492081 cites W2107839228 @default.
• W4285492081 cites W2130423812 @default.
• W4285492081 cites W2137526110 @default.
• W4285492081 cites W2154811915 @default.
• W4285492081 cites W2163375473 @default.
• W4285492081 cites W2169456326 @default.
• W4285492081 cites W2170420350 @default.
• W4285492081 cites W2170446948 @default.
• W4285492081 cites W2171209671 @default.
• W4285492081 cites W2175277699 @default.
• W4285492081 cites W2294779636 @default.
• W4285492081 cites W2417464115 @default.
• W4285492081 cites W2521212135 @default.
• W4285492081 cites W2570066480 @default.
• W4285492081 cites W2588436363 @default.
• W4285492081 cites W2760714521 @default.
• W4285492081 cites W2772904315 @default.
• W4285492081 cites W2909876769 @default.
• W4285492081 cites W2910904530 @default.
• W4285492081 cites W2913434193 @default.
• W4285492081 cites W2951391897 @default.
• W4285492081 cites W2970358232 @default.
• W4285492081 cites W2984347539 @default.
• W4285492081 cites W3041476024 @default.
• W4285492081 cites W3151147170 @default.
• W4285492081 cites W3161428456 @default.
• W4285492081 cites W3164784413 @default.
• W4285492081 cites W3183555104 @default.
• W4285492081 cites W4255156463 @default.
• W4285492081 doi "https://doi.org/10.1038/s41598-022-16448-0" @default.
• W4285492081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35840794" @default.
• W4285492081 hasPublicationYear "2022" @default.
• W4285492081 type Work @default.
• W4285492081 citedByCount "8" @default.
• W4285492081 countsByYear W42854920812022 @default.
• W4285492081 countsByYear W42854920812023 @default.
• W4285492081 crossrefType "journal-article" @default.
• W4285492081 hasAuthorship W4285492081A5008003184 @default.
• W4285492081 hasAuthorship W4285492081A5015302194 @default.
• W4285492081 hasAuthorship W4285492081A5025598471 @default.
• W4285492081 hasAuthorship W4285492081A5036089972 @default.
• W4285492081 hasAuthorship W4285492081A5046489406 @default.
• W4285492081 hasAuthorship W4285492081A5070319781 @default.
• W4285492081 hasAuthorship W4285492081A5071862673 @default.
• W4285492081 hasAuthorship W4285492081A5083868539 @default.
• W4285492081 hasBestOaLocation W42854920811 @default.
• W4285492081 hasConcept C104317684 @default.
• W4285492081 hasConcept C105580179 @default.
• W4285492081 hasConcept C119056186 @default.
• W4285492081 hasConcept C145059251 @default.
• W4285492081 hasConcept C150194340 @default.
• W4285492081 hasConcept C2775905019 @default.
• W4285492081 hasConcept C54009773 @default.
• W4285492081 hasConcept C54355233 @default.
• W4285492081 hasConcept C60644358 @default.
• W4285492081 hasConcept C67705224 @default.
• W4285492081 hasConcept C70721500 @default.
• W4285492081 hasConcept C86803240 @default.
• W4285492081 hasConceptScore W4285492081C104317684 @default.
• W4285492081 hasConceptScore W4285492081C105580179 @default.
• W4285492081 hasConceptScore W4285492081C119056186 @default.
• W4285492081 hasConceptScore W4285492081C145059251 @default.
• W4285492081 hasConceptScore W4285492081C150194340 @default.
• W4285492081 hasConceptScore W4285492081C2775905019 @default.
• W4285492081 hasConceptScore W4285492081C54009773 @default.
• W4285492081 hasConceptScore W4285492081C54355233 @default.
• W4285492081 hasConceptScore W4285492081C60644358 @default.
• W4285492081 hasConceptScore W4285492081C67705224 @default.
• W4285492081 hasConceptScore W4285492081C70721500 @default.
• W4285492081 hasConceptScore W4285492081C86803240 @default.
• W4285492081 hasFunder F4320310758 @default.

• next