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• W4285492616 endingPage "2091" @default.
• W4285492616 startingPage "2086" @default.
• W4285492616 abstract "Hepatocellular carcinoma (HCC) is the fifth most diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Sorafenib is the standard treatment used in the advanced stages of HCC. Cell therapy with mesenchymal stem cells (MSCs)-based cell therapy has proven effective in immune regulation and tumour growth inhibition.In this study, we investigated the anti-inflammatory effect of MSCs on HCC xenografts.Human HepG2 cell lines were subcutaneously implanted into the flank of 12 nude mice, divided into three groups: the control group, the IV group (intravenous MSCs injection) and the local group (local MSCs injection). Mice were sacrificed 6 weeks after tumour implantation, and tumours were resected entirety. Quantitative real-time polymerase chain reaction (qRT-PCR) measured the gene expression of inflammatory markers, including tumour necrosis factor-α (TNF-α), interleukin (IL)-1α and IL-10. Aspartate transaminase (AST), alanine transaminase (ALT) and urea levels were measured using spectrophotometry to ensure the safety of MSC therapy.Gene expressions for all three inflammatory markers were reduced in both MSCs groups compared to the control group. AST, ALT and urea levels remained in normal ranges.MSC therapy can reduce inflammation in HCC xenograft mouse models." @default.
• W4285492616 created "2022-07-15" @default.
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• W4285492616 date "2022-07-15" @default.
• W4285492616 modified "2023-09-27" @default.
• W4285492616 title "Anti‐inflammatory effect of mesenchymal stem cells on hepatocellular carcinoma in the xenograft mice model" @default.
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• W4285492616 doi "https://doi.org/10.1002/vms3.886" @default.
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