FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285493560> ?p ?o ?g. }

• W4285493560 endingPage "2921" @default.
• W4285493560 startingPage "2907" @default.
• W4285493560 abstract "Recently developed nanocones (NCs), which are inclusion complexes that are made up of cyclodextrins (CDs) and perfluorocarbons (PFCs), have shown promising results in nanoparticle-mediated histotripsy (NMH) applications due to stable inclusion complexation, PFC quantification, simple synthesis, and processing. FDA-approved βCD and its modified versions such as low-degree methylated βCD have been previously demonstrated as prime examples of structures capable of accommodating PFC molecules. However, the complex formation potential of different CDs with various cavity sizes in the presence of PFC molecules, and their consequent aggregation, needs to be explored. In the present study, the complexation and aggregation potential of some natural CDs and their respective derivatives either exposed to perfluoropentane (PFP) or perfluorohexane (PFH) were studied in the wet lab. Computational studies were also performed to account for the limitations faced in PFC quantification because of the low optical density of PFCs within the CD complex and to discover the best candidate for NMH applications. All results revealed that only βCD and γCD (except HMγCD) derivatives form an inclusion complex with PFCs and only LMβCD, βCD, and γCD form nanocone clusters (NCCs), which precipitate and can be collected for use. Furthermore, the data collectively show that βCD and PFCs have the best complexation due to stable complex formation, ease of production, and product recovery, especially with PFH as a more suitable candidate due to its high boiling point, which allows workability during synthesis. Although simulations suggest that highly stable inclusion complexes exist, such as HPβCD, the cluster formation resulting in precipitation is hindered due to the high solubility of CDs in water, resulting in intangible yields to work with even after employing general laboratory recovery methods. Conclusively, histotripsy cavitation experiments successfully showed a decreased cavitation threshold among optimal NCC candidates that were identified, supporting their use in NMH." @default.
• W4285493560 created "2022-07-15" @default.
• W4285493560 creator A5009244204 @default.
• W4285493560 creator A5057659093 @default.
• W4285493560 creator A5071475167 @default.
• W4285493560 creator A5072174803 @default.
• W4285493560 creator A5075962456 @default.
• W4285493560 creator A5091615479 @default.
• W4285493560 date "2022-07-15" @default.
• W4285493560 modified "2023-09-29" @default.
• W4285493560 title "Experimental and Computational Investigation of Clustering Behavior of Cyclodextrin–Perfluorocarbon Inclusion Complexes as Effective Histotripsy Agents" @default.
• W4285493560 cites W1759700083 @default.
• W4285493560 cites W1835312245 @default.
• W4285493560 cites W1969153543 @default.
• W4285493560 cites W1969516222 @default.
• W4285493560 cites W1970935015 @default.
• W4285493560 cites W1980551862 @default.
• W4285493560 cites W1981021420 @default.
• W4285493560 cites W1986305407 @default.
• W4285493560 cites W2001570423 @default.
• W4285493560 cites W2009776197 @default.
• W4285493560 cites W2021520922 @default.
• W4285493560 cites W2028549018 @default.
• W4285493560 cites W2029667189 @default.
• W4285493560 cites W2029796212 @default.
• W4285493560 cites W2031953074 @default.
• W4285493560 cites W2032349754 @default.
• W4285493560 cites W2044127910 @default.
• W4285493560 cites W2050259375 @default.
• W4285493560 cites W2053684203 @default.
• W4285493560 cites W2060079863 @default.
• W4285493560 cites W2066202134 @default.
• W4285493560 cites W2067045265 @default.
• W4285493560 cites W2074829362 @default.
• W4285493560 cites W2080292900 @default.
• W4285493560 cites W2081693079 @default.
• W4285493560 cites W2090717492 @default.
• W4285493560 cites W2094097178 @default.
• W4285493560 cites W2106606597 @default.
• W4285493560 cites W2116455804 @default.
• W4285493560 cites W2151152537 @default.
• W4285493560 cites W2206954826 @default.
• W4285493560 cites W2239903836 @default.
• W4285493560 cites W2296911262 @default.
• W4285493560 cites W2306659280 @default.
• W4285493560 cites W2332616754 @default.
• W4285493560 cites W2529304545 @default.
• W4285493560 cites W2555553141 @default.
• W4285493560 cites W2586488755 @default.
• W4285493560 cites W2761556684 @default.
• W4285493560 cites W2766972987 @default.
• W4285493560 cites W2793251872 @default.
• W4285493560 cites W2915142334 @default.
• W4285493560 cites W2923673138 @default.
• W4285493560 cites W2943942823 @default.
• W4285493560 cites W2954208736 @default.
• W4285493560 cites W3112258298 @default.
• W4285493560 cites W3209414320 @default.
• W4285493560 cites W4211053799 @default.
• W4285493560 doi "https://doi.org/10.1021/acs.molpharmaceut.2c00268" @default.
• W4285493560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35839291" @default.
• W4285493560 hasPublicationYear "2022" @default.
• W4285493560 type Work @default.
• W4285493560 citedByCount "2" @default.
• W4285493560 countsByYear W42854935602022 @default.
• W4285493560 countsByYear W42854935602023 @default.
• W4285493560 crossrefType "journal-article" @default.
• W4285493560 hasAuthorship W4285493560A5009244204 @default.
• W4285493560 hasAuthorship W4285493560A5057659093 @default.
• W4285493560 hasAuthorship W4285493560A5071475167 @default.
• W4285493560 hasAuthorship W4285493560A5072174803 @default.
• W4285493560 hasAuthorship W4285493560A5075962456 @default.
• W4285493560 hasAuthorship W4285493560A5091615479 @default.
• W4285493560 hasConcept C109359841 @default.
• W4285493560 hasConcept C147597530 @default.
• W4285493560 hasConcept C155672457 @default.
• W4285493560 hasConcept C164866538 @default.
• W4285493560 hasConcept C171250308 @default.
• W4285493560 hasConcept C178790620 @default.
• W4285493560 hasConcept C185592680 @default.
• W4285493560 hasConcept C192562407 @default.
• W4285493560 hasConcept C199289684 @default.
• W4285493560 hasConcept C199360897 @default.
• W4285493560 hasConcept C21951064 @default.
• W4285493560 hasConcept C2779433975 @default.
• W4285493560 hasConcept C32909587 @default.
• W4285493560 hasConcept C41008148 @default.
• W4285493560 hasConceptScore W4285493560C109359841 @default.
• W4285493560 hasConceptScore W4285493560C147597530 @default.
• W4285493560 hasConceptScore W4285493560C155672457 @default.
• W4285493560 hasConceptScore W4285493560C164866538 @default.
• W4285493560 hasConceptScore W4285493560C171250308 @default.
• W4285493560 hasConceptScore W4285493560C178790620 @default.
• W4285493560 hasConceptScore W4285493560C185592680 @default.
• W4285493560 hasConceptScore W4285493560C192562407 @default.
• W4285493560 hasConceptScore W4285493560C199289684 @default.
• W4285493560 hasConceptScore W4285493560C199360897 @default.
• W4285493560 hasConceptScore W4285493560C21951064 @default.

• next