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- W4285493643 abstract "Talin is a force-sensing multidomain protein and a major player in cellular mechanotransduction. Here, we use single-molecule magnetic tweezers to investigate the mechanical response of the R8 rod domain of talin. We find that under various force cycles, the R8 domain of talin can display a memory-dependent behavior: At the same low force (<10 pN), the same protein molecule shows vastly different unfolding kinetics. This history-dependent behavior indicates the evolution of a unique force-induced native state. We measure through mechanical unfolding that talin R8 domain binds one of its ligands, DLC1, with much higher affinity than previously reported. This strong interaction can explain the antitumor response of DLC1 by regulating inside-out activation of integrins. Together, our results paint a complex picture for the mechanical unfolding of talin in the physiological range and a new mechanism of function of DLC1 to regulate inside-out activation of integrins." @default.
- W4285493643 created "2022-07-15" @default.
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- W4285493643 date "2022-07-15" @default.
- W4285493643 modified "2023-10-05" @default.
- W4285493643 title "Mechanical regulation of talin through binding and history-dependent unfolding" @default.
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- W4285493643 doi "https://doi.org/10.1126/sciadv.abl7719" @default.
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