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- W4285494039 abstract "Abstract Coronary artery endothelial cells (CAEC) exert an important role in the development of cardiovascular disease. Dysfunction of CAEC is associated with cardiovascular disease in subjects with type 2 diabetes mellitus (T2DM). However, comprehensive studies of the effects that a diabetic environment exerts on this cellular type are scarce. The present study characterized the molecular perturbations occurring on cultured bovine CAEC subjected to a prolonged diabetic environment (high glucose and high insulin). Changes at the metabolite and peptide level were assessed by Liquid Chromatography–Mass Spectrometry (LC–MS 2 ) and chemoinformatics. The results were integrated with published LC–MS 2 -based quantitative proteomics on the same in vitro model. Our findings were consistent with reports on other endothelial cell types and identified novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism in cells under a diabetic environment. Manual data inspection revealed disturbances on tryptophan catabolism and biosynthesis of phenylalanine-based, glutathione-based, and proline-based peptide metabolites. Fluorescence microscopy detected an increase in binucleation in cells under treatment that also occurred when human CAEC were used. This multi-omics study identified particular molecular perturbations in an induced diabetic environment that could help unravel the mechanisms underlying the development of cardiovascular disease in subjects with T2DM." @default.
- W4285494039 created "2022-07-15" @default.
- W4285494039 creator A5001182420 @default.
- W4285494039 creator A5003150097 @default.
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- W4285494039 creator A5052515623 @default.
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- W4285494039 creator A5071847854 @default.
- W4285494039 date "2022-07-14" @default.
- W4285494039 modified "2023-10-06" @default.
- W4285494039 title "Multi-omics study identifies novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism by simulated diabetes on coronary endothelial cells" @default.
- W4285494039 cites W1237871938 @default.
- W4285494039 cites W1566538275 @default.
- W4285494039 cites W1583655086 @default.
- W4285494039 cites W1865776599 @default.
- W4285494039 cites W1965283399 @default.
- W4285494039 cites W1966423289 @default.
- W4285494039 cites W1967425491 @default.
- W4285494039 cites W1971427269 @default.
- W4285494039 cites W1972978498 @default.
- W4285494039 cites W1977276752 @default.
- W4285494039 cites W1978934920 @default.
- W4285494039 cites W1984784075 @default.
- W4285494039 cites W1989277387 @default.
- W4285494039 cites W1989299822 @default.
- W4285494039 cites W1991145737 @default.
- W4285494039 cites W1997048738 @default.
- W4285494039 cites W1998288227 @default.
- W4285494039 cites W2006382243 @default.
- W4285494039 cites W2012645913 @default.
- W4285494039 cites W2013715939 @default.
- W4285494039 cites W2015886796 @default.
- W4285494039 cites W2017771330 @default.
- W4285494039 cites W2019338486 @default.
- W4285494039 cites W2020565041 @default.
- W4285494039 cites W2021242983 @default.
- W4285494039 cites W2023461657 @default.
- W4285494039 cites W2029342214 @default.
- W4285494039 cites W2032093326 @default.
- W4285494039 cites W2035986594 @default.
- W4285494039 cites W2038095540 @default.
- W4285494039 cites W2044192315 @default.
- W4285494039 cites W2053124968 @default.
- W4285494039 cites W2054129051 @default.
- W4285494039 cites W2058571957 @default.
- W4285494039 cites W2065083810 @default.
- W4285494039 cites W2067278779 @default.
- W4285494039 cites W2076066590 @default.
- W4285494039 cites W2081221799 @default.
- W4285494039 cites W2085760247 @default.
- W4285494039 cites W2088639163 @default.
- W4285494039 cites W2092145650 @default.
- W4285494039 cites W2092732789 @default.
- W4285494039 cites W2093639021 @default.
- W4285494039 cites W2093918937 @default.
- W4285494039 cites W2093954354 @default.
- W4285494039 cites W2094166943 @default.
- W4285494039 cites W2096171976 @default.
- W4285494039 cites W2096173332 @default.
- W4285494039 cites W2097070591 @default.
- W4285494039 cites W2098036900 @default.
- W4285494039 cites W2104888323 @default.
- W4285494039 cites W2105216337 @default.
- W4285494039 cites W2113570557 @default.
- W4285494039 cites W2115129497 @default.
- W4285494039 cites W2116537176 @default.
- W4285494039 cites W2118709967 @default.
- W4285494039 cites W2118863552 @default.
- W4285494039 cites W2123980413 @default.
- W4285494039 cites W2127013573 @default.
- W4285494039 cites W2135674854 @default.
- W4285494039 cites W2152877944 @default.
- W4285494039 cites W2158968180 @default.
- W4285494039 cites W2159482845 @default.
- W4285494039 cites W2159675211 @default.
- W4285494039 cites W2164335474 @default.
- W4285494039 cites W2166854945 @default.
- W4285494039 cites W2205469249 @default.
- W4285494039 cites W2284443530 @default.
- W4285494039 cites W2299224499 @default.
- W4285494039 cites W2301577374 @default.
- W4285494039 cites W2306356166 @default.
- W4285494039 cites W2322580831 @default.
- W4285494039 cites W2324021033 @default.
- W4285494039 cites W2331594022 @default.
- W4285494039 cites W2405250182 @default.
- W4285494039 cites W2414963831 @default.
- W4285494039 cites W2496272489 @default.
- W4285494039 cites W2504691963 @default.
- W4285494039 cites W2548357532 @default.
- W4285494039 cites W2551876238 @default.
- W4285494039 cites W2572344066 @default.
- W4285494039 cites W2598111690 @default.
- W4285494039 cites W2605996197 @default.
- W4285494039 cites W2781939187 @default.
- W4285494039 cites W2786512177 @default.
- W4285494039 cites W2800712778 @default.
- W4285494039 cites W2807572295 @default.
- W4285494039 cites W2807814263 @default.