FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285494080> ?p ?o ?g. }

• W4285494080 abstract "Dengue is a disease that poses a significant global public health concern. Although a tetravalent live-attenuated dengue vaccine has been licensed, its efficacy is still debated due to evidence of vaccine breakthrough infection. To avoid this issue, dengue vaccines should stimulate a high degree of serotype-specific response. Thus, envelope domain III (EDIII), which contains serotype-specific neutralizing epitopes, is an attractive target for dengue vaccine development. In this study, we investigated how EDIII encapsidated in N, N, N-trimethyl chitosan chloride nanoparticles (TMC NPs) stimulates a serotype-specific response and whether this response exerts a potential in vitro breakthrough infection. The immune response to DENV-2 elicited by EDIII TMC NP-immunized mice was monitored. We demonstrated that immunization with EDIII TMC NPs resulted in a high level of anti-EDIII antibody production. These antibodies included IgG, IgG1, and IgG2a subtypes. Importantly, antibodies from the immunized mice exerted efficient neutralizing activity with undetectable antibody dependent enhancement (ADE) activity. We also found that EDIII TMC NPs activated functional EDIII-specific CD4+ and CD8+ T cell responses. In conclusion, EDIII TMC NPs stimulated humoral immunity with a strong neutralizing antibody response, as well as a cellular immune response against DENV-2." @default.
• W4285494080 created "2022-07-15" @default.
• W4285494080 creator A5016116371 @default.
• W4285494080 creator A5018992560 @default.
• W4285494080 creator A5031518279 @default.
• W4285494080 creator A5044550703 @default.
• W4285494080 creator A5053010588 @default.
• W4285494080 date "2022-07-14" @default.
• W4285494080 modified "2023-10-16" @default.
• W4285494080 title "Mice immunized with trimethyl chitosan nanoparticles containing DENV-2 envelope domain III elicit neutralizing antibodies with undetectable antibody-dependent enhancement activity" @default.
• W4285494080 cites W1017348960 @default.
• W4285494080 cites W1513149807 @default.
• W4285494080 cites W1942194807 @default.
• W4285494080 cites W1989555063 @default.
• W4285494080 cites W1989946260 @default.
• W4285494080 cites W2017081541 @default.
• W4285494080 cites W2025870915 @default.
• W4285494080 cites W2033702349 @default.
• W4285494080 cites W2069542935 @default.
• W4285494080 cites W2073023385 @default.
• W4285494080 cites W2101355465 @default.
• W4285494080 cites W2116471574 @default.
• W4285494080 cites W2126789944 @default.
• W4285494080 cites W2131222241 @default.
• W4285494080 cites W2139197205 @default.
• W4285494080 cites W2141264905 @default.
• W4285494080 cites W2144095627 @default.
• W4285494080 cites W2146980643 @default.
• W4285494080 cites W2164079841 @default.
• W4285494080 cites W2166183736 @default.
• W4285494080 cites W2292286849 @default.
• W4285494080 cites W2338936985 @default.
• W4285494080 cites W2626980526 @default.
• W4285494080 cites W2751187040 @default.
• W4285494080 cites W2755447033 @default.
• W4285494080 cites W2767429166 @default.
• W4285494080 cites W2796317357 @default.
• W4285494080 cites W2888408905 @default.
• W4285494080 cites W2899117288 @default.
• W4285494080 cites W2913941694 @default.
• W4285494080 cites W2969579093 @default.
• W4285494080 cites W2982514532 @default.
• W4285494080 cites W2987109794 @default.
• W4285494080 cites W3014923257 @default.
• W4285494080 cites W3047550066 @default.
• W4285494080 cites W3059988113 @default.
• W4285494080 cites W3092502920 @default.
• W4285494080 cites W3093994474 @default.
• W4285494080 cites W3155932922 @default.
• W4285494080 cites W3180638661 @default.
• W4285494080 cites W3208758937 @default.
• W4285494080 doi "https://doi.org/10.1099/jgv.0.001768" @default.
• W4285494080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35833704" @default.
• W4285494080 hasPublicationYear "2022" @default.
• W4285494080 type Work @default.
• W4285494080 citedByCount "2" @default.
• W4285494080 countsByYear W42854940802023 @default.
• W4285494080 crossrefType "journal-article" @default.
• W4285494080 hasAuthorship W4285494080A5016116371 @default.
• W4285494080 hasAuthorship W4285494080A5018992560 @default.
• W4285494080 hasAuthorship W4285494080A5031518279 @default.
• W4285494080 hasAuthorship W4285494080A5044550703 @default.
• W4285494080 hasAuthorship W4285494080A5053010588 @default.
• W4285494080 hasConcept C159047783 @default.
• W4285494080 hasConcept C159654299 @default.
• W4285494080 hasConcept C195616568 @default.
• W4285494080 hasConcept C196594336 @default.
• W4285494080 hasConcept C203014093 @default.
• W4285494080 hasConcept C2522874641 @default.
• W4285494080 hasConcept C2779261636 @default.
• W4285494080 hasConcept C2779308166 @default.
• W4285494080 hasConcept C2779635636 @default.
• W4285494080 hasConcept C2780801004 @default.
• W4285494080 hasConcept C533803919 @default.
• W4285494080 hasConcept C86803240 @default.
• W4285494080 hasConcept C8891405 @default.
• W4285494080 hasConceptScore W4285494080C159047783 @default.
• W4285494080 hasConceptScore W4285494080C159654299 @default.
• W4285494080 hasConceptScore W4285494080C195616568 @default.
• W4285494080 hasConceptScore W4285494080C196594336 @default.
• W4285494080 hasConceptScore W4285494080C203014093 @default.
• W4285494080 hasConceptScore W4285494080C2522874641 @default.
• W4285494080 hasConceptScore W4285494080C2779261636 @default.
• W4285494080 hasConceptScore W4285494080C2779308166 @default.
• W4285494080 hasConceptScore W4285494080C2779635636 @default.
• W4285494080 hasConceptScore W4285494080C2780801004 @default.
• W4285494080 hasConceptScore W4285494080C533803919 @default.
• W4285494080 hasConceptScore W4285494080C86803240 @default.
• W4285494080 hasConceptScore W4285494080C8891405 @default.
• W4285494080 hasIssue "7" @default.
• W4285494080 hasLocation W42854940801 @default.
• W4285494080 hasLocation W42854940802 @default.
• W4285494080 hasOpenAccess W4285494080 @default.
• W4285494080 hasPrimaryLocation W42854940801 @default.
• W4285494080 hasRelatedWork W2005243362 @default.
• W4285494080 hasRelatedWork W2056019569 @default.
• W4285494080 hasRelatedWork W2081356962 @default.
• W4285494080 hasRelatedWork W2100364502 @default.
• W4285494080 hasRelatedWork W2101355465 @default.
• W4285494080 hasRelatedWork W2121043049 @default.

• next