FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285494311> ?p ?o ?g. }

• W4285494311 abstract "Immune sensing of the Gram-negative bacterial membrane glycolipid lipopolysaccharide (LPS) is both a critical component of host defense against bacterial infection and a contributor to the hyperinflammatory response, potentially leading to sepsis and death. Innate immune activation by LPS is due to the lipid A moiety, an acylated di-glucosamine molecule that can activate inflammatory responses via the extracellular sensor Toll-like receptor 4 (TLR4)/myeloid differentiation 2 (MD2) or the cytosolic sensor caspase-11 (Casp11). The number and length of acyl chains present on bacterial lipid A structures vary across bacterial species and strains, which affects the magnitude of TLR4 and Casp11 activation. TLR4 and Casp11 are thought to respond similarly to various lipid A structures, as tetra-acylated lipid A structures do not activate either sensor, whereas hexa-acylated structures activate both sensors. However, the precise features of lipid A that determine the differential activation of each receptor remain poorly defined, as direct analysis of extracellular and cytosolic responses to the same sources and preparations of LPS/lipid A structures have been limited. To address this question, we used rationally engineered lipid A isolated from a series of bacterial acyl-transferase mutants that produce novel, structurally defined molecules. Intriguingly, we found that the location of specific secondary acyl chains on lipid A resulted in differential recognition by TLR4 or Casp11, providing new insight into the structural features of lipid A required to activate either TLR4 or Casp11. Our findings indicate that TLR4 and Casp11 sense nonoverlapping areas of lipid A chemical space, thereby constraining the ability of Gram-negative pathogens to evade innate immunity." @default.
• W4285494311 created "2022-07-15" @default.
• W4285494311 creator A5028965776 @default.
• W4285494311 creator A5043813423 @default.
• W4285494311 creator A5044396416 @default.
• W4285494311 creator A5047643709 @default.
• W4285494311 creator A5059475430 @default.
• W4285494311 creator A5077095423 @default.
• W4285494311 date "2022-08-18" @default.
• W4285494311 modified "2023-10-02" @default.
• W4285494311 title "Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11" @default.
• W4285494311 cites W1501009591 @default.
• W4285494311 cites W1553904897 @default.
• W4285494311 cites W1864325817 @default.
• W4285494311 cites W1882905539 @default.
• W4285494311 cites W1886793353 @default.
• W4285494311 cites W1891980138 @default.
• W4285494311 cites W1968299377 @default.
• W4285494311 cites W1978926805 @default.
• W4285494311 cites W1979318608 @default.
• W4285494311 cites W1984035213 @default.
• W4285494311 cites W1985319029 @default.
• W4285494311 cites W1991564172 @default.
• W4285494311 cites W2003112779 @default.
• W4285494311 cites W2009034382 @default.
• W4285494311 cites W2023142724 @default.
• W4285494311 cites W2023368253 @default.
• W4285494311 cites W2033023829 @default.
• W4285494311 cites W2035337730 @default.
• W4285494311 cites W2050788919 @default.
• W4285494311 cites W2055727949 @default.
• W4285494311 cites W2068619092 @default.
• W4285494311 cites W2073016175 @default.
• W4285494311 cites W2074180829 @default.
• W4285494311 cites W2078895028 @default.
• W4285494311 cites W2080827095 @default.
• W4285494311 cites W2100770441 @default.
• W4285494311 cites W2103550937 @default.
• W4285494311 cites W2105263387 @default.
• W4285494311 cites W2107111524 @default.
• W4285494311 cites W2115893060 @default.
• W4285494311 cites W2117362458 @default.
• W4285494311 cites W2117840998 @default.
• W4285494311 cites W2123577868 @default.
• W4285494311 cites W2127934565 @default.
• W4285494311 cites W2128942089 @default.
• W4285494311 cites W2129258112 @default.
• W4285494311 cites W2130655121 @default.
• W4285494311 cites W2130673227 @default.
• W4285494311 cites W2132032241 @default.
• W4285494311 cites W2143102054 @default.
• W4285494311 cites W2145638464 @default.
• W4285494311 cites W2150292428 @default.
• W4285494311 cites W2154202775 @default.
• W4285494311 cites W2159866361 @default.
• W4285494311 cites W2164237791 @default.
• W4285494311 cites W2171780940 @default.
• W4285494311 cites W2312149817 @default.
• W4285494311 cites W2576519196 @default.
• W4285494311 cites W2612082723 @default.
• W4285494311 cites W2755464515 @default.
• W4285494311 cites W2783543761 @default.
• W4285494311 cites W2802890766 @default.
• W4285494311 cites W2808965517 @default.
• W4285494311 cites W2888308014 @default.
• W4285494311 cites W2930171358 @default.
• W4285494311 cites W2941651253 @default.
• W4285494311 cites W3034751517 @default.
• W4285494311 cites W3037348091 @default.
• W4285494311 cites W3135048787 @default.
• W4285494311 cites W3192590880 @default.
• W4285494311 cites W3207060296 @default.
• W4285494311 cites W4285494899 @default.
• W4285494311 cites W4548231 @default.
• W4285494311 doi "https://doi.org/10.1128/iai.00201-22" @default.
• W4285494311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35862717" @default.
• W4285494311 hasPublicationYear "2022" @default.
• W4285494311 type Work @default.
• W4285494311 citedByCount "5" @default.
• W4285494311 countsByYear W42854943112022 @default.
• W4285494311 countsByYear W42854943112023 @default.
• W4285494311 crossrefType "journal-article" @default.
• W4285494311 hasAuthorship W4285494311A5028965776 @default.
• W4285494311 hasAuthorship W4285494311A5043813423 @default.
• W4285494311 hasAuthorship W4285494311A5044396416 @default.
• W4285494311 hasAuthorship W4285494311A5047643709 @default.
• W4285494311 hasAuthorship W4285494311A5059475430 @default.
• W4285494311 hasAuthorship W4285494311A5077095423 @default.
• W4285494311 hasBestOaLocation W42854943112 @default.
• W4285494311 hasConcept C111289621 @default.
• W4285494311 hasConcept C136449434 @default.
• W4285494311 hasConcept C144464004 @default.
• W4285494311 hasConcept C170493617 @default.
• W4285494311 hasConcept C203014093 @default.
• W4285494311 hasConcept C2776070231 @default.
• W4285494311 hasConcept C2776709828 @default.
• W4285494311 hasConcept C2778754761 @default.
• W4285494311 hasConcept C55493867 @default.
• W4285494311 hasConcept C86803240 @default.
• W4285494311 hasConcept C95444343 @default.

• next