Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285494927> ?p ?o ?g. }
- W4285494927 abstract "Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases. Inflammation in ATs is characterized by macrophage infiltration and the activation of inflammatory pathways mediated by NF-κB, JNK, and NLRP3 inflammasomes. Adipokines, hepatokines and myokines — proteins secreted from AT, the liver and skeletal muscle play regulatory roles in AT inflammation via endocrine, paracrine, and autocrine pathways. For example, obesity is associated with elevated levels of pro-inflammatory adipokines (e.g., leptin, resistin, chemerin, progranulin, RBP4, WISP1, FABP4, PAI-1, Follistatin-like1, MCP-1, SPARC, SPARCL1, and SAA) and reduced levels of anti-inflammatory adipokines such as adiponectin, omentin, ZAG, SFRP5, CTRP3, vaspin, and IL-10. Moreover, some hepatokines (Fetuin A, DPP4, FGF21, GDF15, and MANF) and myokines (irisin, IL-6, and DEL-1) also play pro- or anti-inflammatory roles in AT inflammation. This review aims to provide an updated understanding of these organokines and their role in AT inflammation and related metabolic abnormalities. It serves to highlight the molecular mechanisms underlying the effects of these organokines and their clinical significance. Insights into the roles and mechanisms of these organokines could provide novel and potential therapeutic targets for obesity-induced inflammation." @default.
- W4285494927 created "2022-07-15" @default.
- W4285494927 creator A5002967869 @default.
- W4285494927 creator A5018938572 @default.
- W4285494927 creator A5042533860 @default.
- W4285494927 creator A5057420024 @default.
- W4285494927 creator A5061664113 @default.
- W4285494927 creator A5063868428 @default.
- W4285494927 creator A5070046055 @default.
- W4285494927 creator A5083494218 @default.
- W4285494927 date "2022-07-14" @default.
- W4285494927 modified "2023-10-15" @default.
- W4285494927 title "Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation" @default.
- W4285494927 cites W1485601868 @default.
- W4285494927 cites W1504735357 @default.
- W4285494927 cites W1517209311 @default.
- W4285494927 cites W1529154968 @default.
- W4285494927 cites W1535671016 @default.
- W4285494927 cites W1576884145 @default.
- W4285494927 cites W1590967073 @default.
- W4285494927 cites W1654453027 @default.
- W4285494927 cites W1675830194 @default.
- W4285494927 cites W173084735 @default.
- W4285494927 cites W1788396114 @default.
- W4285494927 cites W1845255770 @default.
- W4285494927 cites W1851118215 @default.
- W4285494927 cites W1872721533 @default.
- W4285494927 cites W1891161709 @default.
- W4285494927 cites W1928962200 @default.
- W4285494927 cites W1931609017 @default.
- W4285494927 cites W1963540704 @default.
- W4285494927 cites W1964044812 @default.
- W4285494927 cites W1965437905 @default.
- W4285494927 cites W1966091545 @default.
- W4285494927 cites W1966675928 @default.
- W4285494927 cites W1968091833 @default.
- W4285494927 cites W1968699284 @default.
- W4285494927 cites W1969696561 @default.
- W4285494927 cites W1971226856 @default.
- W4285494927 cites W1973259074 @default.
- W4285494927 cites W1973591364 @default.
- W4285494927 cites W1975330009 @default.
- W4285494927 cites W1975994080 @default.
- W4285494927 cites W1977407489 @default.
- W4285494927 cites W1979030077 @default.
- W4285494927 cites W1979286266 @default.
- W4285494927 cites W1979916078 @default.
- W4285494927 cites W1980660681 @default.
- W4285494927 cites W1980767631 @default.
- W4285494927 cites W1981261500 @default.
- W4285494927 cites W1983011875 @default.
- W4285494927 cites W1984513167 @default.
- W4285494927 cites W1984898285 @default.
- W4285494927 cites W1987081490 @default.
- W4285494927 cites W1988926458 @default.
- W4285494927 cites W1989150212 @default.
- W4285494927 cites W1989584881 @default.
- W4285494927 cites W1990443193 @default.
- W4285494927 cites W1990932830 @default.
- W4285494927 cites W1993239839 @default.
- W4285494927 cites W1995253456 @default.
- W4285494927 cites W1996713062 @default.
- W4285494927 cites W1997748417 @default.
- W4285494927 cites W1998888166 @default.
- W4285494927 cites W2000665430 @default.
- W4285494927 cites W2001495518 @default.
- W4285494927 cites W2002789245 @default.
- W4285494927 cites W2003029905 @default.
- W4285494927 cites W2003106237 @default.
- W4285494927 cites W2004456757 @default.
- W4285494927 cites W2005505978 @default.
- W4285494927 cites W2007106585 @default.
- W4285494927 cites W2007822694 @default.
- W4285494927 cites W2008675205 @default.
- W4285494927 cites W2008869160 @default.
- W4285494927 cites W2008898747 @default.
- W4285494927 cites W2009141333 @default.
- W4285494927 cites W2012430430 @default.
- W4285494927 cites W2014804054 @default.
- W4285494927 cites W2015355519 @default.
- W4285494927 cites W2017400542 @default.
- W4285494927 cites W2018630214 @default.
- W4285494927 cites W2018934343 @default.
- W4285494927 cites W2019642669 @default.
- W4285494927 cites W2019790788 @default.
- W4285494927 cites W2021004639 @default.
- W4285494927 cites W2022252635 @default.
- W4285494927 cites W2022291198 @default.
- W4285494927 cites W2023797875 @default.
- W4285494927 cites W2024378513 @default.
- W4285494927 cites W2025327530 @default.
- W4285494927 cites W2025611086 @default.
- W4285494927 cites W2026921468 @default.
- W4285494927 cites W2028107793 @default.
- W4285494927 cites W2028320377 @default.
- W4285494927 cites W2031640133 @default.
- W4285494927 cites W2031815559 @default.
- W4285494927 cites W2032310689 @default.
- W4285494927 cites W2032919119 @default.
- W4285494927 cites W2033556255 @default.