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- W4285495320 abstract "Microglia are important resident immune cells in the central nervous system (CNS) and play an important role in its development, homeostasis, and disease treatments. Activated microglia perform diverse functions in mouse models of CNS neurodegenerative diseases or deficits. In humans, microglia have been linked to various neurodegenerative diseases. Following brain or spinal cord injury, microglia express pro- and anti-inflammatory phenotypes at different stages of recovery. With the development of pharmacological and genetic tools for microglial depletion, studies have demonstrated that microglial depletion exerts both positive and negative effects in the treatment of CNS diseases. Notably, microglial depletion provides an empty niche that stimulates production of new microglia. Microglial depletion and repopulation can not only treat diseases by eliminating dysfunctional microglia but can also provide an indication of the molecular mechanisms of diseases. Although this approach has shown impressive results, its use is still in its infancy. In this review, we summarize the current pharmacological and genetic tools for microglial depletion and highlight recent advances in microglial repopulation therapy for the treatment and functional recovery of neurological diseases and deficits. Finally, we briefly discuss the therapeutic challenges and prospective uses of microglial repopulation therapy." @default.
- W4285495320 created "2022-07-15" @default.
- W4285495320 creator A5003541586 @default.
- W4285495320 creator A5017947172 @default.
- W4285495320 creator A5018474752 @default.
- W4285495320 creator A5022017895 @default.
- W4285495320 creator A5072218107 @default.
- W4285495320 creator A5078805296 @default.
- W4285495320 creator A5084848342 @default.
- W4285495320 date "2022-07-14" @default.
- W4285495320 modified "2023-10-18" @default.
- W4285495320 title "Restorative therapy using microglial depletion and repopulation for central nervous system injuries and diseases" @default.
- W4285495320 cites W1515023627 @default.
- W4285495320 cites W1522823711 @default.
- W4285495320 cites W1599691548 @default.
- W4285495320 cites W1879142474 @default.
- W4285495320 cites W1914782230 @default.
- W4285495320 cites W1920357305 @default.
- W4285495320 cites W1971969390 @default.
- W4285495320 cites W1993677761 @default.
- W4285495320 cites W1999952543 @default.
- W4285495320 cites W2006517495 @default.
- W4285495320 cites W2014545259 @default.
- W4285495320 cites W2016575029 @default.
- W4285495320 cites W2019604999 @default.
- W4285495320 cites W2023592848 @default.
- W4285495320 cites W2024193688 @default.
- W4285495320 cites W2024698694 @default.
- W4285495320 cites W2027467386 @default.
- W4285495320 cites W2045152845 @default.
- W4285495320 cites W2051504363 @default.
- W4285495320 cites W2056123178 @default.
- W4285495320 cites W2067267561 @default.
- W4285495320 cites W2073607297 @default.
- W4285495320 cites W2080499279 @default.
- W4285495320 cites W2080706272 @default.
- W4285495320 cites W2082414904 @default.
- W4285495320 cites W2098038342 @default.
- W4285495320 cites W2104431737 @default.
- W4285495320 cites W2114440499 @default.
- W4285495320 cites W2124836944 @default.
- W4285495320 cites W2125393554 @default.
- W4285495320 cites W2127381922 @default.
- W4285495320 cites W2140139281 @default.
- W4285495320 cites W2142242761 @default.
- W4285495320 cites W2146156306 @default.
- W4285495320 cites W2148898943 @default.
- W4285495320 cites W2153406260 @default.
- W4285495320 cites W2155115959 @default.
- W4285495320 cites W2155172987 @default.
- W4285495320 cites W2155702815 @default.
- W4285495320 cites W2158707363 @default.
- W4285495320 cites W2160779535 @default.
- W4285495320 cites W2163470859 @default.
- W4285495320 cites W2163857997 @default.
- W4285495320 cites W2164144078 @default.
- W4285495320 cites W2169700519 @default.
- W4285495320 cites W2170959966 @default.
- W4285495320 cites W2171467864 @default.
- W4285495320 cites W2234872056 @default.
- W4285495320 cites W2281702574 @default.
- W4285495320 cites W2293957414 @default.
- W4285495320 cites W2298647235 @default.
- W4285495320 cites W2338975497 @default.
- W4285495320 cites W2345329114 @default.
- W4285495320 cites W2345745180 @default.
- W4285495320 cites W2439312023 @default.
- W4285495320 cites W2468501494 @default.
- W4285495320 cites W2497241389 @default.
- W4285495320 cites W2507620027 @default.
- W4285495320 cites W2511658934 @default.
- W4285495320 cites W2537351581 @default.
- W4285495320 cites W2546451980 @default.
- W4285495320 cites W2558246554 @default.
- W4285495320 cites W2569935680 @default.
- W4285495320 cites W2586662902 @default.
- W4285495320 cites W2586825713 @default.
- W4285495320 cites W2594403755 @default.
- W4285495320 cites W2606527202 @default.
- W4285495320 cites W2625911761 @default.
- W4285495320 cites W2745295358 @default.
- W4285495320 cites W2745849139 @default.
- W4285495320 cites W2753593979 @default.
- W4285495320 cites W2766759903 @default.
- W4285495320 cites W2767429780 @default.
- W4285495320 cites W2774947569 @default.
- W4285495320 cites W2789309735 @default.
- W4285495320 cites W2791700208 @default.
- W4285495320 cites W2791920202 @default.
- W4285495320 cites W2795211569 @default.
- W4285495320 cites W2797791176 @default.
- W4285495320 cites W2804029280 @default.
- W4285495320 cites W2892332054 @default.
- W4285495320 cites W2894428253 @default.
- W4285495320 cites W2894787694 @default.
- W4285495320 cites W2897258146 @default.
- W4285495320 cites W2897353323 @default.
- W4285495320 cites W2898278833 @default.
- W4285495320 cites W2898314619 @default.
- W4285495320 cites W2899263110 @default.