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- W4285495770 endingPage "987" @default.
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- W4285495770 abstract "The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of COVID-19 infection that is the starting point in the generation of microthrombi and sepsis eventually leading to acute respiratory distress syndrome (ARDs) and multi-organ failure. The dramatic fall in lung function during ARDs is attributed to the microthrombi-induced coagulopathy primed by a hyperactive immune system. Due to the lack of effective antiviral agents, the line of treatment is limited to the management of two key risk factors i.e., immune activation and coagulopathy. In the present review, we describe the mechanistic role, therapeutic targets, and opportunities to control immune activation and coagulopathy during the pathogenesis of COVID-19-induced ARDs." @default.
- W4285495770 created "2022-07-15" @default.
- W4285495770 creator A5024414960 @default.
- W4285495770 creator A5027610429 @default.
- W4285495770 creator A5051577763 @default.
- W4285495770 creator A5066043886 @default.
- W4285495770 date "2023-07-01" @default.
- W4285495770 modified "2023-09-27" @default.
- W4285495770 title "Therapeutic Approaches for Intravascular Microthrombi-induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Infection" @default.
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