Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285495860> ?p ?o ?g. }
- W4285495860 endingPage "7726" @default.
- W4285495860 startingPage "7726" @default.
- W4285495860 abstract "Neurotrophins are a family of secreted proteins expressed in the peripheral nervous system and the central nervous system that support neuronal survival, synaptic plasticity, and neurogenesis. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor TrkB are highly expressed in the cortical and hippocampal areas and play an essential role in learning and memory. The decline of cognitive function with aging is a major risk factor for cognitive diseases such as Alzheimer's disease. Therefore, an alteration of BDNF/TrkB signaling with aging and/or pathological conditions has been indicated as a potential mechanism of cognitive decline. In this review, we summarize the cellular function of neurotrophin signaling and review the current evidence indicating a pathological role of neurotrophin signaling, especially of BDNF/TrkB signaling, in the cognitive decline in aging and age-related cognitive diseases. We also review the therapeutic approach for cognitive decline by the upregulation of the endogenous BDNF/TrkB-system." @default.
- W4285495860 created "2022-07-15" @default.
- W4285495860 creator A5022705084 @default.
- W4285495860 creator A5087822481 @default.
- W4285495860 date "2022-07-13" @default.
- W4285495860 modified "2023-10-14" @default.
- W4285495860 title "The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases" @default.
- W4285495860 cites W1519555255 @default.
- W4285495860 cites W1531290450 @default.
- W4285495860 cites W1571221025 @default.
- W4285495860 cites W1933828059 @default.
- W4285495860 cites W1960312392 @default.
- W4285495860 cites W1966534777 @default.
- W4285495860 cites W1968135525 @default.
- W4285495860 cites W1969479602 @default.
- W4285495860 cites W1973883693 @default.
- W4285495860 cites W1974476511 @default.
- W4285495860 cites W1974701801 @default.
- W4285495860 cites W1979125819 @default.
- W4285495860 cites W1981288686 @default.
- W4285495860 cites W1984460802 @default.
- W4285495860 cites W1987433942 @default.
- W4285495860 cites W1987742395 @default.
- W4285495860 cites W1989053030 @default.
- W4285495860 cites W1989491769 @default.
- W4285495860 cites W1995290481 @default.
- W4285495860 cites W1997814051 @default.
- W4285495860 cites W2000209446 @default.
- W4285495860 cites W2007539627 @default.
- W4285495860 cites W2011965698 @default.
- W4285495860 cites W2014256027 @default.
- W4285495860 cites W2029863311 @default.
- W4285495860 cites W2034275126 @default.
- W4285495860 cites W2035717344 @default.
- W4285495860 cites W2039047987 @default.
- W4285495860 cites W2039255376 @default.
- W4285495860 cites W2042547835 @default.
- W4285495860 cites W2043103881 @default.
- W4285495860 cites W2049860163 @default.
- W4285495860 cites W2065482131 @default.
- W4285495860 cites W2067302534 @default.
- W4285495860 cites W2070993776 @default.
- W4285495860 cites W2071610467 @default.
- W4285495860 cites W2073642667 @default.
- W4285495860 cites W2077662314 @default.
- W4285495860 cites W2079472132 @default.
- W4285495860 cites W2080487891 @default.
- W4285495860 cites W2083439934 @default.
- W4285495860 cites W2083909434 @default.
- W4285495860 cites W2087160678 @default.
- W4285495860 cites W2091927578 @default.
- W4285495860 cites W2115818030 @default.
- W4285495860 cites W2119184935 @default.
- W4285495860 cites W2119757776 @default.
- W4285495860 cites W2134241742 @default.
- W4285495860 cites W2138182618 @default.
- W4285495860 cites W2147515151 @default.
- W4285495860 cites W2151986987 @default.
- W4285495860 cites W2154727263 @default.
- W4285495860 cites W2163247992 @default.
- W4285495860 cites W2164219261 @default.
- W4285495860 cites W2168820134 @default.
- W4285495860 cites W2403171683 @default.
- W4285495860 cites W2411593190 @default.
- W4285495860 cites W2461377175 @default.
- W4285495860 cites W2470343227 @default.
- W4285495860 cites W2529170838 @default.
- W4285495860 cites W2606501237 @default.
- W4285495860 cites W2624853583 @default.
- W4285495860 cites W2753555237 @default.
- W4285495860 cites W2810724956 @default.
- W4285495860 cites W2811192525 @default.
- W4285495860 cites W2887013859 @default.
- W4285495860 cites W2892177856 @default.
- W4285495860 cites W2898837587 @default.
- W4285495860 cites W2900530928 @default.
- W4285495860 cites W2901734506 @default.
- W4285495860 cites W2905067650 @default.
- W4285495860 cites W2911286776 @default.
- W4285495860 cites W2925056974 @default.
- W4285495860 cites W2964392188 @default.
- W4285495860 cites W2974868658 @default.
- W4285495860 cites W3006001937 @default.
- W4285495860 cites W3029938902 @default.
- W4285495860 cites W3128033471 @default.
- W4285495860 cites W3165420479 @default.
- W4285495860 cites W4200050093 @default.
- W4285495860 cites W4200343653 @default.
- W4285495860 cites W4200593356 @default.
- W4285495860 cites W4214677311 @default.
- W4285495860 cites W4214763578 @default.
- W4285495860 cites W4214869279 @default.
- W4285495860 cites W4214883332 @default.
- W4285495860 cites W4220657478 @default.
- W4285495860 cites W4220699562 @default.
- W4285495860 cites W4220737691 @default.
- W4285495860 cites W4220742604 @default.
- W4285495860 cites W4220942717 @default.