FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285496640> ?p ?o ?g. }

• W4285496640 abstract "Exposure to MHC-antigen complexes on the surface of antigen-presenting cells (APCs) activates T cells, inducing the formation of the immune synapse (IS). Antigen detection at the APC surface is thus a critical step in the adaptive immune response. The physical properties of antigen-presenting surfaces encountered by T cells in vivo are believed to modulate T cell activation and proliferation. Although stiffness and ligand mobility influence IS formation, the effect of the complex topography of the APC surface on this process is not well understood. Here we investigate how nanotopography modulates cytoskeletal dynamics and signaling during the early stages of T cell activation using high-resolution fluorescence microscopy on nanofabricated surfaces with parallel nanoridges of different spacings. We find that although nanoridges reduce the maximum spread area as compared with cells on flat surfaces, the ridges enhance the accumulation of actin and the signaling kinase ZAP-70 at the IS. Actin polymerization is more dynamic in the presence of ridges, which influence the directionality of both actin flows and microtubule (MT) growth. Our results demonstrate that the topography of the activating surface exerts both global effects on T cell morphology and local changes in actin and MT dynamics, collectively influencing T cell signaling." @default.
• W4285496640 created "2022-07-15" @default.
• W4285496640 creator A5004279067 @default.
• W4285496640 creator A5015720046 @default.
• W4285496640 creator A5029561595 @default.
• W4285496640 creator A5030496088 @default.
• W4285496640 creator A5036355464 @default.
• W4285496640 creator A5047747299 @default.
• W4285496640 creator A5056504447 @default.
• W4285496640 date "2022-09-01" @default.
• W4285496640 modified "2023-09-27" @default.
• W4285496640 title "Nanotopography modulates cytoskeletal organization and dynamics during T cell activation" @default.
• W4285496640 cites W1504427671 @default.
• W4285496640 cites W1567219703 @default.
• W4285496640 cites W1610585913 @default.
• W4285496640 cites W1902556066 @default.
• W4285496640 cites W1963639964 @default.
• W4285496640 cites W1965010125 @default.
• W4285496640 cites W1970037077 @default.
• W4285496640 cites W1993369787 @default.
• W4285496640 cites W1996939435 @default.
• W4285496640 cites W2023450381 @default.
• W4285496640 cites W2024863574 @default.
• W4285496640 cites W2025748968 @default.
• W4285496640 cites W2027498023 @default.
• W4285496640 cites W2038082227 @default.
• W4285496640 cites W2054808321 @default.
• W4285496640 cites W2061806013 @default.
• W4285496640 cites W2065240922 @default.
• W4285496640 cites W2073539506 @default.
• W4285496640 cites W2078387056 @default.
• W4285496640 cites W2090827542 @default.
• W4285496640 cites W2091599094 @default.
• W4285496640 cites W2094476644 @default.
• W4285496640 cites W2096700643 @default.
• W4285496640 cites W2099107111 @default.
• W4285496640 cites W2104744849 @default.
• W4285496640 cites W2105916176 @default.
• W4285496640 cites W2115294635 @default.
• W4285496640 cites W2116113317 @default.
• W4285496640 cites W2116987767 @default.
• W4285496640 cites W2128981602 @default.
• W4285496640 cites W2133240422 @default.
• W4285496640 cites W2155493718 @default.
• W4285496640 cites W2314653534 @default.
• W4285496640 cites W2344335337 @default.
• W4285496640 cites W2544486379 @default.
• W4285496640 cites W2588457461 @default.
• W4285496640 cites W2612927424 @default.
• W4285496640 cites W2613004608 @default.
• W4285496640 cites W2621590149 @default.
• W4285496640 cites W2746240834 @default.
• W4285496640 cites W2749209632 @default.
• W4285496640 cites W2782959503 @default.
• W4285496640 cites W2791670200 @default.
• W4285496640 cites W2797648693 @default.
• W4285496640 cites W2803840621 @default.
• W4285496640 cites W2897556827 @default.
• W4285496640 cites W2906607503 @default.
• W4285496640 cites W3005178835 @default.
• W4285496640 cites W3005339273 @default.
• W4285496640 cites W3112305242 @default.
• W4285496640 cites W3140960189 @default.
• W4285496640 cites W3162752789 @default.
• W4285496640 cites W4255375128 @default.
• W4285496640 doi "https://doi.org/10.1091/mbc.e21-12-0601" @default.
• W4285496640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35830602" @default.
• W4285496640 hasPublicationYear "2022" @default.
• W4285496640 type Work @default.
• W4285496640 citedByCount "3" @default.
• W4285496640 countsByYear W42854966402023 @default.
• W4285496640 crossrefType "journal-article" @default.
• W4285496640 hasAuthorship W4285496640A5004279067 @default.
• W4285496640 hasAuthorship W4285496640A5015720046 @default.
• W4285496640 hasAuthorship W4285496640A5029561595 @default.
• W4285496640 hasAuthorship W4285496640A5030496088 @default.
• W4285496640 hasAuthorship W4285496640A5036355464 @default.
• W4285496640 hasAuthorship W4285496640A5047747299 @default.
• W4285496640 hasAuthorship W4285496640A5056504447 @default.
• W4285496640 hasBestOaLocation W42854966402 @default.
• W4285496640 hasConcept C12554922 @default.
• W4285496640 hasConcept C125705527 @default.
• W4285496640 hasConcept C142669718 @default.
• W4285496640 hasConcept C1491633281 @default.
• W4285496640 hasConcept C19317047 @default.
• W4285496640 hasConcept C203014093 @default.
• W4285496640 hasConcept C2776090121 @default.
• W4285496640 hasConcept C2777803738 @default.
• W4285496640 hasConcept C2993400109 @default.
• W4285496640 hasConcept C3620293 @default.
• W4285496640 hasConcept C55493867 @default.
• W4285496640 hasConcept C86803240 @default.
• W4285496640 hasConcept C8891405 @default.
• W4285496640 hasConcept C95444343 @default.
• W4285496640 hasConcept C9756297 @default.
• W4285496640 hasConceptScore W4285496640C12554922 @default.
• W4285496640 hasConceptScore W4285496640C125705527 @default.
• W4285496640 hasConceptScore W4285496640C142669718 @default.
• W4285496640 hasConceptScore W4285496640C1491633281 @default.
• W4285496640 hasConceptScore W4285496640C19317047 @default.

• next