Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285496723> ?p ?o ?g. }
- W4285496723 endingPage "297" @default.
- W4285496723 startingPage "290" @default.
- W4285496723 abstract "Background: Combined PD-1/PD-L1 and CTLA-4 immune checkpoint inhibition for the has been shown to produce superior results in the treatment of malignant melanoma when compared to monotherapy. However, patients with intracranial disease were excluded from these studies given their poor prognosis. Objective: The objective of this study was to critically assess current evidence supporting the co-administration of PD-1/PD-L1 and CTLA-4 inhibitors in the treatment of melanoma brain metastases. Methods: The objective was addressed through the development of a critically appraised topic that included a clinical scenario, structured question, literature search strategy, critical appraisal, assessment of results, evidence summary, commentary, and bottom-line conclusions. Participants included consultant and resident neurologists, a medical librarian, clinical epidemiologists, and a content expert in the field of neuro-oncology. Results: A recent, open-label, non-comparative randomized phase II trial was selected for critical appraisal. This trial evaluated the efficacy and safety of nivolumab alone or in combination with ipilimumab in 79 adult patients with untreated, asymptomatic melanoma brain metastases. The rates of the primary outcome (intracranial response at ≥12 wk) in the primary endpoint cohort were 46% for cohort A (combination therapy) and 20% for cohort B (nivolumab monotherapy). No treatment related deaths were observed in the study. Grade 4 adverse events occurred in 9% of patients in cohort A and none in cohort B. Conclusions: Co-administration of ipilimumab and nivolumab as first-line therapy is effective in the treatment of asymptomatic melanoma brain metastases, with an acceptable safety profile." @default.
- W4285496723 created "2022-07-15" @default.
- W4285496723 creator A5008002660 @default.
- W4285496723 creator A5014909652 @default.
- W4285496723 creator A5069125641 @default.
- W4285496723 creator A5070208366 @default.
- W4285496723 creator A5089626904 @default.
- W4285496723 date "2022-07-12" @default.
- W4285496723 modified "2023-10-17" @default.
- W4285496723 title "In Patients With Melanoma Brain Metastases, Is Combination Immune Checkpoint Inhibition a Safe and Effective First-Line Treatment? A Critically Appraised Topic" @default.
- W4285496723 cites W1759766614 @default.
- W4285496723 cites W1834835434 @default.
- W4285496723 cites W1965911653 @default.
- W4285496723 cites W1977666111 @default.
- W4285496723 cites W1981472724 @default.
- W4285496723 cites W1989683871 @default.
- W4285496723 cites W1995103475 @default.
- W4285496723 cites W2003959352 @default.
- W4285496723 cites W2019607817 @default.
- W4285496723 cites W2026764424 @default.
- W4285496723 cites W2029286945 @default.
- W4285496723 cites W2057293767 @default.
- W4285496723 cites W2058026920 @default.
- W4285496723 cites W2061733422 @default.
- W4285496723 cites W2062247475 @default.
- W4285496723 cites W2065626916 @default.
- W4285496723 cites W2070259449 @default.
- W4285496723 cites W2080345303 @default.
- W4285496723 cites W2082289634 @default.
- W4285496723 cites W2084281756 @default.
- W4285496723 cites W2090793580 @default.
- W4285496723 cites W2091100650 @default.
- W4285496723 cites W2093856946 @default.
- W4285496723 cites W2103220202 @default.
- W4285496723 cites W2111137187 @default.
- W4285496723 cites W2122079447 @default.
- W4285496723 cites W2140585508 @default.
- W4285496723 cites W2166478145 @default.
- W4285496723 cites W2317854588 @default.
- W4285496723 cites W2335935187 @default.
- W4285496723 cites W2416791964 @default.
- W4285496723 cites W2562656839 @default.
- W4285496723 cites W2612010935 @default.
- W4285496723 cites W2620651944 @default.
- W4285496723 cites W2753432434 @default.
- W4285496723 cites W2794627893 @default.
- W4285496723 cites W2808814350 @default.
- W4285496723 cites W2888298425 @default.
- W4285496723 cites W3086473620 @default.
- W4285496723 cites W4232356790 @default.
- W4285496723 cites W62225863 @default.
- W4285496723 doi "https://doi.org/10.1097/nrl.0000000000000439" @default.
- W4285496723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35834790" @default.
- W4285496723 hasPublicationYear "2022" @default.
- W4285496723 type Work @default.
- W4285496723 citedByCount "1" @default.
- W4285496723 countsByYear W42854967232023 @default.
- W4285496723 crossrefType "journal-article" @default.
- W4285496723 hasAuthorship W4285496723A5008002660 @default.
- W4285496723 hasAuthorship W4285496723A5014909652 @default.
- W4285496723 hasAuthorship W4285496723A5069125641 @default.
- W4285496723 hasAuthorship W4285496723A5070208366 @default.
- W4285496723 hasAuthorship W4285496723A5089626904 @default.
- W4285496723 hasConcept C121608353 @default.
- W4285496723 hasConcept C126322002 @default.
- W4285496723 hasConcept C143998085 @default.
- W4285496723 hasConcept C197934379 @default.
- W4285496723 hasConcept C203092338 @default.
- W4285496723 hasConcept C2777658100 @default.
- W4285496723 hasConcept C2777701055 @default.
- W4285496723 hasConcept C2777910003 @default.
- W4285496723 hasConcept C2780030458 @default.
- W4285496723 hasConcept C2781433595 @default.
- W4285496723 hasConcept C502942594 @default.
- W4285496723 hasConcept C535046627 @default.
- W4285496723 hasConcept C71924100 @default.
- W4285496723 hasConcept C72563966 @default.
- W4285496723 hasConceptScore W4285496723C121608353 @default.
- W4285496723 hasConceptScore W4285496723C126322002 @default.
- W4285496723 hasConceptScore W4285496723C143998085 @default.
- W4285496723 hasConceptScore W4285496723C197934379 @default.
- W4285496723 hasConceptScore W4285496723C203092338 @default.
- W4285496723 hasConceptScore W4285496723C2777658100 @default.
- W4285496723 hasConceptScore W4285496723C2777701055 @default.
- W4285496723 hasConceptScore W4285496723C2777910003 @default.
- W4285496723 hasConceptScore W4285496723C2780030458 @default.
- W4285496723 hasConceptScore W4285496723C2781433595 @default.
- W4285496723 hasConceptScore W4285496723C502942594 @default.
- W4285496723 hasConceptScore W4285496723C535046627 @default.
- W4285496723 hasConceptScore W4285496723C71924100 @default.
- W4285496723 hasConceptScore W4285496723C72563966 @default.
- W4285496723 hasIssue "5" @default.
- W4285496723 hasLocation W42854967231 @default.
- W4285496723 hasLocation W42854967232 @default.
- W4285496723 hasOpenAccess W4285496723 @default.
- W4285496723 hasPrimaryLocation W42854967231 @default.
- W4285496723 hasRelatedWork W2745358348 @default.
- W4285496723 hasRelatedWork W2888298425 @default.