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- W4285498082 abstract "Hierarchically assembled nanostructured apatitic (HANA) mesoporous particles have been hailed as potential drug delivery agents. However, their synthesis is intricate, and synthesis process parameters critically affect their formation. This investigation comprehensively evaluated the effects of both temperature and duration of hydrothermal heating on the architecture and structure of HANA particles. Variations in temperature and heating duration unfolded various HANA particle morphologies, including bundle-like, flower-like, dumbbell-like, and spherical-ended dumbbell-like particles. All morphologies exhibited monolithic apatitic structures with varying crystallinity and lattice strain. Also, particles exhibited mesoporous structures with superior surface area (16–23 m2g-1) and pore volume (0.009–0.048 cm3g-1). Spherical-ended dumbbell-like particles displayed strong drug encapsulation efficiency and improved pharmacokinetics in simulated body conditions based on their ionic release rate, drug loading, and release rate testings. Therefore, an amalgamation of amazing properties of HANA particles proposed their therapeutic applications as agents for controlled drug administration and tissue restoration multifunctions." @default.
- W4285498082 created "2022-07-15" @default.
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- W4285498082 date "2022-11-01" @default.
- W4285498082 modified "2023-10-16" @default.
- W4285498082 title "Novel morphologies of mesoporous hierarchically assembled nanostructured hydroxyapatite particles: Influence of some synthesis conditions" @default.
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- W4285498082 doi "https://doi.org/10.1016/j.ceramint.2022.07.027" @default.
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