Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285503060> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4285503060 endingPage "83" @default.
- W4285503060 startingPage "76" @default.
- W4285503060 abstract "The recent approval of disease-modifying therapies for spinal muscular atrophy (SMA) raised the need of alternative outcome measures to evaluate treatment efficacy. In this study, we investigated the potential of muscle quantitative MRI (qMRI) as a biomarker of disease progression in adult SMA3 patients during nusinersen treatment. Six adult SMA3 patients (age ranging from 19 to 65 years) underwent 2-point Dixon muscle qMRI at beginning of nusinersen treatment (T0) and after 14 months (T14) to evaluate the muscle fat fraction (FF) at thigh and leg levels; patients were clinically assessed at T0 and T14 with the Hammersmith Functional Rating Scale Expanded (HFMSE), the Revised Upper Limb Module (RULM) and the 6-minute walk test (6MWT). At T0, vastus lateralis muscle displayed the highest mean FF (67.5%), while tibialis anterior was the most preserved one (mean FF = 35.2%). At T0, a slightly significant correlation of FF with HFMSE (p = 0.042) and disease duration (p = 0.042) at thigh level and only with HFMSE (p = 0.042) at leg level was found. At T14, no significant change of mean FF values at thigh and leg muscles was found compared to T0. Conversely, a statistically significant (p = 0.042) improvement of HFMSE was reported at T14. We observed no significant change of FF in thigh and leg muscles after 14 months of nusinersen therapy despite a significant clinical improvement of HFMSE. Further studies with longer follow-up and larger cohorts are needed to better investigate the role of qMRI as marker of disease progression in SMA patients." @default.
- W4285503060 created "2022-07-15" @default.
- W4285503060 creator A5004622787 @default.
- W4285503060 creator A5024553622 @default.
- W4285503060 creator A5036176403 @default.
- W4285503060 creator A5039110035 @default.
- W4285503060 creator A5069017360 @default.
- W4285503060 creator A5075494523 @default.
- W4285503060 creator A5089464740 @default.
- W4285503060 date "2022-06-01" @default.
- W4285503060 modified "2023-10-12" @default.
- W4285503060 title "Muscle quantitative MRI in adult SMA patients on nusinersen treatment: a longitudinal study." @default.
- W4285503060 cites W1975139695 @default.
- W4285503060 cites W1987757405 @default.
- W4285503060 cites W2002340042 @default.
- W4285503060 cites W2167790027 @default.
- W4285503060 cites W2277280343 @default.
- W4285503060 cites W2309887726 @default.
- W4285503060 cites W2591057488 @default.
- W4285503060 cites W2606866670 @default.
- W4285503060 cites W2765483614 @default.
- W4285503060 cites W2789114047 @default.
- W4285503060 cites W2792451264 @default.
- W4285503060 cites W2913924970 @default.
- W4285503060 cites W2990689917 @default.
- W4285503060 cites W3011851030 @default.
- W4285503060 cites W3013371597 @default.
- W4285503060 cites W3035514338 @default.
- W4285503060 cites W3043287113 @default.
- W4285503060 cites W3045989829 @default.
- W4285503060 cites W3084730147 @default.
- W4285503060 cites W3092919613 @default.
- W4285503060 cites W3123519011 @default.
- W4285503060 cites W3133270341 @default.
- W4285503060 cites W3150267725 @default.
- W4285503060 cites W4206816660 @default.
- W4285503060 doi "https://doi.org/10.36185/2532-1900-074" @default.
- W4285503060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35832502" @default.
- W4285503060 hasPublicationYear "2022" @default.
- W4285503060 type Work @default.
- W4285503060 citedByCount "1" @default.
- W4285503060 countsByYear W42855030602023 @default.
- W4285503060 crossrefType "journal-article" @default.
- W4285503060 hasAuthorship W4285503060A5004622787 @default.
- W4285503060 hasAuthorship W4285503060A5024553622 @default.
- W4285503060 hasAuthorship W4285503060A5036176403 @default.
- W4285503060 hasAuthorship W4285503060A5039110035 @default.
- W4285503060 hasAuthorship W4285503060A5069017360 @default.
- W4285503060 hasAuthorship W4285503060A5075494523 @default.
- W4285503060 hasAuthorship W4285503060A5089464740 @default.
- W4285503060 hasConcept C114614502 @default.
- W4285503060 hasConcept C126322002 @default.
- W4285503060 hasConcept C141071460 @default.
- W4285503060 hasConcept C161921814 @default.
- W4285503060 hasConcept C1862650 @default.
- W4285503060 hasConcept C2776263037 @default.
- W4285503060 hasConcept C2776643329 @default.
- W4285503060 hasConcept C2778558090 @default.
- W4285503060 hasConcept C2779018429 @default.
- W4285503060 hasConcept C2779134260 @default.
- W4285503060 hasConcept C2779959927 @default.
- W4285503060 hasConcept C2781172350 @default.
- W4285503060 hasConcept C33923547 @default.
- W4285503060 hasConcept C71924100 @default.
- W4285503060 hasConcept C99508421 @default.
- W4285503060 hasConceptScore W4285503060C114614502 @default.
- W4285503060 hasConceptScore W4285503060C126322002 @default.
- W4285503060 hasConceptScore W4285503060C141071460 @default.
- W4285503060 hasConceptScore W4285503060C161921814 @default.
- W4285503060 hasConceptScore W4285503060C1862650 @default.
- W4285503060 hasConceptScore W4285503060C2776263037 @default.
- W4285503060 hasConceptScore W4285503060C2776643329 @default.
- W4285503060 hasConceptScore W4285503060C2778558090 @default.
- W4285503060 hasConceptScore W4285503060C2779018429 @default.
- W4285503060 hasConceptScore W4285503060C2779134260 @default.
- W4285503060 hasConceptScore W4285503060C2779959927 @default.
- W4285503060 hasConceptScore W4285503060C2781172350 @default.
- W4285503060 hasConceptScore W4285503060C33923547 @default.
- W4285503060 hasConceptScore W4285503060C71924100 @default.
- W4285503060 hasConceptScore W4285503060C99508421 @default.
- W4285503060 hasIssue "2" @default.
- W4285503060 hasLocation W42855030601 @default.
- W4285503060 hasOpenAccess W4285503060 @default.
- W4285503060 hasPrimaryLocation W42855030601 @default.
- W4285503060 hasRelatedWork W17458057 @default.
- W4285503060 hasRelatedWork W18058602 @default.
- W4285503060 hasRelatedWork W19261907 @default.
- W4285503060 hasRelatedWork W4184255 @default.
- W4285503060 hasRelatedWork W4422945 @default.
- W4285503060 hasRelatedWork W5705787 @default.
- W4285503060 hasRelatedWork W5738058 @default.
- W4285503060 hasRelatedWork W832664 @default.
- W4285503060 hasRelatedWork W9768009 @default.
- W4285503060 hasRelatedWork W9888412 @default.
- W4285503060 hasVolume "41" @default.
- W4285503060 isParatext "false" @default.
- W4285503060 isRetracted "false" @default.
- W4285503060 workType "article" @default.