FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285588052> ?p ?o ?g. }

• W4285588052 abstract "Abstract Acupuncture plays a vital anti-inflammatory action on sepsis through activating autonomic nerve anti-inflammatory pathways, such as sympathoadrenal medullary pathway, but the mechanism remains unclear. This study aims to explore the optimum parameter of electroacupuncture (EA) stimulation in regulating sympathoadrenal medullary pathway and evaluate EA’s anti-inflammatory effect on sepsis. To explore the optimum parameter of EA at homosegmental acupoint on adrenal sympathetic activity, the left adrenal sympathetic nerve firing rate evoked by different intensities of single shock electrical stimulation (ES) at ST25 in healthy male Sprague-Dawley (SD) rats were evaluated by in vivo electrophysiological recording, and the levels of norepinephrine (NE) and its metabolites were also examined using mass spectrometry. To verify the role of EA at ST25 in sepsis, the rat was given intraperitoneal injection lipopolysaccharide to induce sepsis model, and survival rate, clinical score, and the level of interleukin (IL)-6, IL-1β, and IL-10 were evaluated after EA application. We observed that 3 mA is the optimal intensity on activating adrenal sympathetic nerve, which significantly elevated the level of NE in the peripheral blood. For LPS-treated rats, EA at the ST25 apparently increased the survival rate and improved the clinical score compared to the control group. Furthermore, 3 mA EA at ST25 significantly decreased pro-inflammatory cytokines IL-6 and IL-1β and upregulated anti-inflammatory cytokine IL-10 compared to the Lipopolysaccharide (LPS)-treated group. Overall, these data suggest that 3 mA is the optimal EA intensity at ST25 to activate the sympathoadrenal medullary pathway and exert an anti-inflammatory effect on sepsis. Highlights 3 mA single shock ES at ST25 drove adrenal sympathetic nerve reflexs. 3 mA EA at ST25 upregulated NE concentration in peripheral blood. EA at ST25 improved the survival rate in a rat of LPS-induced sepsis model. EA at the ST25 upregulated anti-inflammatory IL10 and downregulated pro-inflammatory IL1β and IL-6 in LPS-treated rats." @default.
• W4285588052 created "2022-07-16" @default.
• W4285588052 creator A5005338865 @default.
• W4285588052 creator A5024304090 @default.
• W4285588052 creator A5034958307 @default.
• W4285588052 creator A5038136744 @default.
• W4285588052 creator A5039104479 @default.
• W4285588052 creator A5053646746 @default.
• W4285588052 creator A5061506412 @default.
• W4285588052 creator A5073187855 @default.
• W4285588052 date "2022-07-16" @default.
• W4285588052 modified "2023-10-01" @default.
• W4285588052 title "Adrenal sympathetic nerve mediated the anti-inflammatory effect of electroacupuncture at ST25 acupoint on a rat model of sepsis" @default.
• W4285588052 cites W1907832415 @default.
• W4285588052 cites W1963952206 @default.
• W4285588052 cites W1989653436 @default.
• W4285588052 cites W1993341098 @default.
• W4285588052 cites W1995044919 @default.
• W4285588052 cites W2024981885 @default.
• W4285588052 cites W2026580330 @default.
• W4285588052 cites W2027390870 @default.
• W4285588052 cites W2042302510 @default.
• W4285588052 cites W2051617175 @default.
• W4285588052 cites W2081852021 @default.
• W4285588052 cites W2091899475 @default.
• W4285588052 cites W2128414222 @default.
• W4285588052 cites W2130741947 @default.
• W4285588052 cites W2159556577 @default.
• W4285588052 cites W2166190627 @default.
• W4285588052 cites W2280404143 @default.
• W4285588052 cites W250840674 @default.
• W4285588052 cites W2524411259 @default.
• W4285588052 cites W2736383474 @default.
• W4285588052 cites W2744195772 @default.
• W4285588052 cites W2918804459 @default.
• W4285588052 cites W2982027455 @default.
• W4285588052 cites W3016771699 @default.
• W4285588052 cites W3048905934 @default.
• W4285588052 cites W3097775812 @default.
• W4285588052 cites W3106271757 @default.
• W4285588052 cites W3135279538 @default.
• W4285588052 cites W3152723395 @default.
• W4285588052 cites W3184941630 @default.
• W4285588052 cites W3196281118 @default.
• W4285588052 cites W3203399889 @default.
• W4285588052 cites W3205496902 @default.
• W4285588052 cites W4205263055 @default.
• W4285588052 cites W4224923099 @default.
• W4285588052 cites W4283739311 @default.
• W4285588052 doi "https://doi.org/10.1101/2022.07.14.499985" @default.
• W4285588052 hasPublicationYear "2022" @default.
• W4285588052 type Work @default.
• W4285588052 citedByCount "1" @default.
• W4285588052 countsByYear W42855880522023 @default.
• W4285588052 crossrefType "posted-content" @default.
• W4285588052 hasAuthorship W4285588052A5005338865 @default.
• W4285588052 hasAuthorship W4285588052A5024304090 @default.
• W4285588052 hasAuthorship W4285588052A5034958307 @default.
• W4285588052 hasAuthorship W4285588052A5038136744 @default.
• W4285588052 hasAuthorship W4285588052A5039104479 @default.
• W4285588052 hasAuthorship W4285588052A5053646746 @default.
• W4285588052 hasAuthorship W4285588052A5061506412 @default.
• W4285588052 hasAuthorship W4285588052A5073187855 @default.
• W4285588052 hasBestOaLocation W42855880521 @default.
• W4285588052 hasConcept C126322002 @default.
• W4285588052 hasConcept C134018914 @default.
• W4285588052 hasConcept C142724271 @default.
• W4285588052 hasConcept C204787440 @default.
• W4285588052 hasConcept C24998067 @default.
• W4285588052 hasConcept C2775894120 @default.
• W4285588052 hasConcept C2776202274 @default.
• W4285588052 hasConcept C2776394411 @default.
• W4285588052 hasConcept C2778384902 @default.
• W4285588052 hasConcept C2778754761 @default.
• W4285588052 hasConcept C42219234 @default.
• W4285588052 hasConcept C56837625 @default.
• W4285588052 hasConcept C71924100 @default.
• W4285588052 hasConceptScore W4285588052C126322002 @default.
• W4285588052 hasConceptScore W4285588052C134018914 @default.
• W4285588052 hasConceptScore W4285588052C142724271 @default.
• W4285588052 hasConceptScore W4285588052C204787440 @default.
• W4285588052 hasConceptScore W4285588052C24998067 @default.
• W4285588052 hasConceptScore W4285588052C2775894120 @default.
• W4285588052 hasConceptScore W4285588052C2776202274 @default.
• W4285588052 hasConceptScore W4285588052C2776394411 @default.
• W4285588052 hasConceptScore W4285588052C2778384902 @default.
• W4285588052 hasConceptScore W4285588052C2778754761 @default.
• W4285588052 hasConceptScore W4285588052C42219234 @default.
• W4285588052 hasConceptScore W4285588052C56837625 @default.
• W4285588052 hasConceptScore W4285588052C71924100 @default.
• W4285588052 hasLocation W42855880521 @default.
• W4285588052 hasOpenAccess W4285588052 @default.
• W4285588052 hasPrimaryLocation W42855880521 @default.
• W4285588052 hasRelatedWork W1984619393 @default.
• W4285588052 hasRelatedWork W1994554879 @default.
• W4285588052 hasRelatedWork W2034768996 @default.
• W4285588052 hasRelatedWork W2042786471 @default.
• W4285588052 hasRelatedWork W2054992011 @default.
• W4285588052 hasRelatedWork W2058612865 @default.
• W4285588052 hasRelatedWork W2060618991 @default.

• next