Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285590089> ?p ?o ?g. }
- W4285590089 abstract "Cognitive side-effects are an important reason for the limited use of electroconvulsive therapy (ECT). Cognitive side-effects are heterogeneous and occur frequently in older persons. To date, insight into these side-effects is hampered due to inconsistencies in study designs and small sample sizes. Among all cognitive side-effects, confusion and delirious states are especially troublesome for patients, relatives and clinicians. In particular inter-ictal delirium-like states are worrisome, since they may lead to premature treatment discontinuation. Besides a need for further insight into determinants of cognitive side-effects of ECT, there is a great need for treatment options.The Rivastigmine for ECT-induced Cognitive Adverse effects in Late Life depression (RECALL) study combines a multicenter, prospective cohort study on older patients with depression, treated with ECT, with an embedded randomized, placebo-controlled cross-over trial to examine the effect of rivastigmine on inter-ictal delirium. Patients are recruited in four centers across the Netherlands and Belgium. We aim to include 150 patients into the cohort study, in order to be able to subsequently include 30 patients into the trial. Patients are included in the trial when inter-ictal delirium, assessed by the Confusion Assessment method (CAM), or a drop in Mini Mental State Examination (MMSE) score of ≥4 during ECT, develops. In the cohort study, comprehensive measurements of ECT-related cognitive side-effects-and their putative determinants-are done at baseline and during the ECT-course. The primary outcome of the clinical trial is the effectiveness of rivastigmine on inter-ictal delirium-severity, assessed with a change in the Delirium Rating Scale-Revised-98. Secondary outcomes of the clinical trial are several ECT-characteristics and side-effects of rivastigmine.This study is the first clinical trial with a focus on ECT-induced, inter-ictal delirium. The cohort provides the basis for recruitment of patients for the cross-over trial and additionally provides an excellent opportunity to unravel cognitive side-effects of ECT and identify putative determinants. This paper describes the rationale and study protocol.EudraCT 2014-003385-24." @default.
- W4285590089 created "2022-07-16" @default.
- W4285590089 creator A5004439858 @default.
- W4285590089 creator A5006531832 @default.
- W4285590089 creator A5015821976 @default.
- W4285590089 creator A5016039203 @default.
- W4285590089 creator A5025558104 @default.
- W4285590089 creator A5030728536 @default.
- W4285590089 creator A5039365724 @default.
- W4285590089 creator A5045259600 @default.
- W4285590089 creator A5054932985 @default.
- W4285590089 creator A5071247199 @default.
- W4285590089 creator A5072306118 @default.
- W4285590089 creator A5072822778 @default.
- W4285590089 creator A5073849169 @default.
- W4285590089 creator A5077757055 @default.
- W4285590089 creator A5080851763 @default.
- W4285590089 creator A5081049784 @default.
- W4285590089 creator A5081531461 @default.
- W4285590089 creator A5083868517 @default.
- W4285590089 creator A5085661145 @default.
- W4285590089 creator A5091083204 @default.
- W4285590089 date "2022-07-15" @default.
- W4285590089 modified "2023-10-06" @default.
- W4285590089 title "Rivastigmine for ECT-induced cognitive adverse effects in late life depression (RECALL study): A multicenter, randomized, double blind, placebo-controlled, cross-over trial in patients with depression aged 55 years or older: Rationale, objectives and methods" @default.
- W4285590089 cites W1505426793 @default.
- W4285590089 cites W1544359545 @default.
- W4285590089 cites W158332845 @default.
- W4285590089 cites W1660303504 @default.
- W4285590089 cites W1847168837 @default.
- W4285590089 cites W1864981714 @default.
- W4285590089 cites W1895538680 @default.
- W4285590089 cites W1910587025 @default.
- W4285590089 cites W1965918155 @default.
- W4285590089 cites W1970779588 @default.
- W4285590089 cites W1974034298 @default.
- W4285590089 cites W1982921548 @default.
- W4285590089 cites W1984923156 @default.
- W4285590089 cites W1988592570 @default.
- W4285590089 cites W1988958607 @default.
- W4285590089 cites W2008854521 @default.
- W4285590089 cites W2009819148 @default.
- W4285590089 cites W2019388171 @default.
- W4285590089 cites W2033748464 @default.
- W4285590089 cites W2038520149 @default.
- W4285590089 cites W2042444446 @default.
- W4285590089 cites W2045870552 @default.
- W4285590089 cites W2046790400 @default.
- W4285590089 cites W2048646100 @default.
- W4285590089 cites W2052011640 @default.
- W4285590089 cites W2055513188 @default.
- W4285590089 cites W2058161128 @default.
- W4285590089 cites W2063789038 @default.
- W4285590089 cites W2064989035 @default.
- W4285590089 cites W2076064451 @default.
- W4285590089 cites W2081033553 @default.
- W4285590089 cites W2090911922 @default.
- W4285590089 cites W2091931051 @default.
- W4285590089 cites W2096529213 @default.
- W4285590089 cites W2096657471 @default.
- W4285590089 cites W2099066338 @default.
- W4285590089 cites W2105659578 @default.
- W4285590089 cites W2114334028 @default.
- W4285590089 cites W2114943413 @default.
- W4285590089 cites W2120357670 @default.
- W4285590089 cites W2123098876 @default.
- W4285590089 cites W2124084192 @default.
- W4285590089 cites W2127857741 @default.
- W4285590089 cites W2131667381 @default.
- W4285590089 cites W2131823335 @default.
- W4285590089 cites W2132666355 @default.
- W4285590089 cites W2138202604 @default.
- W4285590089 cites W2148080316 @default.
- W4285590089 cites W2164059021 @default.
- W4285590089 cites W2167311298 @default.
- W4285590089 cites W2171129594 @default.
- W4285590089 cites W2171811563 @default.
- W4285590089 cites W2182104458 @default.
- W4285590089 cites W2315187051 @default.
- W4285590089 cites W2316138036 @default.
- W4285590089 cites W2403885475 @default.
- W4285590089 cites W2412239690 @default.
- W4285590089 cites W2469942541 @default.
- W4285590089 cites W2474384324 @default.
- W4285590089 cites W2488194009 @default.
- W4285590089 cites W2593693603 @default.
- W4285590089 cites W2618156443 @default.
- W4285590089 cites W2625796101 @default.
- W4285590089 cites W2792270412 @default.
- W4285590089 cites W2935372078 @default.
- W4285590089 cites W3011017370 @default.
- W4285590089 cites W3016564443 @default.
- W4285590089 cites W3034114277 @default.
- W4285590089 cites W3089838096 @default.
- W4285590089 cites W3178168279 @default.
- W4285590089 cites W3192160346 @default.
- W4285590089 cites W4238079920 @default.
- W4285590089 cites W4292101337 @default.
- W4285590089 cites W73756478 @default.
- W4285590089 cites W91108901 @default.