FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285594286> ?p ?o ?g. }

• W4285594286 abstract "SUMMARY ACE2 is a major receptor for cell entry of SARS-CoV-2. Despite advances in targeting ACE2 to inhibit SARS-CoV-2’s binding, how to efficiently and flexibly control ACE2 levels for prevention of SARS-CoV-2 infection has not been explored. Here, we revealed Vitamin C (VitC) administration as an effective strategy to prevent SARS-CoV-2 infection. VitC reduced ACE2 protein levels in a dose-dependent manner, while partial reduction of ACE2 can greatly restrict SARS-CoV-2 infection. Further studies uncovered that USP50 is a crucial regulator of ACE2 protein levels, and VitC blocks the USP50-ACE2 interaction, thus promoting K48-linked polyubiquitination at Lys788 and degradation of ACE2, without disrupting ACE2 transcriptional expression. Importantly, VitC administration reduced host ACE2 and largely blocked SARS-CoV-2 infection in mice. This study identified an in vivo ACE2 balance controlled by both USP50 and an essential nutrient VitC, and revealed a critical role and application of VitC in daily protection from SARS-CoV-2 infection. Highlights VitC reduces ACE2 protein levels in a dose-dependent manner VitC and USP50 regulate K48-linked ubiquitination at Lys788 of ACE2 VitC blocks the interaction between USP50 and ACE2 VitC administration lowers host ACE2 and prevents SARS-CoV-2 infection in vivo Abstract Figure The deubiquitinase USP50 controls ACE2 protein stability and levels, while Vitamin C blocks the USP50-ACE2 interaction and therefore results in ACE2 degradation, offering a flexible and efficient approach to protection of the host from SARS-CoV-2 infection." @default.
• W4285594286 created "2022-07-16" @default.
• W4285594286 creator A5004098646 @default.
• W4285594286 creator A5007067690 @default.
• W4285594286 creator A5018743839 @default.
• W4285594286 creator A5022382160 @default.
• W4285594286 creator A5024131822 @default.
• W4285594286 creator A5031404818 @default.
• W4285594286 creator A5041043006 @default.
• W4285594286 creator A5042084472 @default.
• W4285594286 creator A5046233154 @default.
• W4285594286 creator A5047989462 @default.
• W4285594286 creator A5077457004 @default.
• W4285594286 creator A5085617980 @default.
• W4285594286 creator A5085731370 @default.
• W4285594286 creator A5087183170 @default.
• W4285594286 creator A5089580435 @default.
• W4285594286 date "2022-07-15" @default.
• W4285594286 modified "2023-10-06" @default.
• W4285594286 title "Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models" @default.
• W4285594286 cites W1978407431 @default.
• W4285594286 cites W2000040025 @default.
• W4285594286 cites W2007922873 @default.
• W4285594286 cites W2008310735 @default.
• W4285594286 cites W2023131478 @default.
• W4285594286 cites W2025672718 @default.
• W4285594286 cites W2028521865 @default.
• W4285594286 cites W2051332153 @default.
• W4285594286 cites W2061895619 @default.
• W4285594286 cites W2157653515 @default.
• W4285594286 cites W2159099334 @default.
• W4285594286 cites W2159630381 @default.
• W4285594286 cites W2160014667 @default.
• W4285594286 cites W2171671715 @default.
• W4285594286 cites W2511022073 @default.
• W4285594286 cites W2766554620 @default.
• W4285594286 cites W2781656467 @default.
• W4285594286 cites W2795939598 @default.
• W4285594286 cites W2979508643 @default.
• W4285594286 cites W3007643904 @default.
• W4285594286 cites W3008827533 @default.
• W4285594286 cites W3009440525 @default.
• W4285594286 cites W3009912996 @default.
• W4285594286 cites W3011134208 @default.
• W4285594286 cites W3014361958 @default.
• W4285594286 cites W3019773443 @default.
• W4285594286 cites W3022288447 @default.
• W4285594286 cites W3038176257 @default.
• W4285594286 cites W3040801404 @default.
• W4285594286 cites W3045720050 @default.
• W4285594286 cites W3088528489 @default.
• W4285594286 cites W3121968914 @default.
• W4285594286 cites W3135002918 @default.
• W4285594286 cites W3192258665 @default.
• W4285594286 cites W3216738767 @default.
• W4285594286 cites W3217514672 @default.
• W4285594286 cites W4200134243 @default.
• W4285594286 cites W4223476013 @default.
• W4285594286 cites W4223929982 @default.
• W4285594286 cites W4281385307 @default.
• W4285594286 doi "https://doi.org/10.1101/2022.07.14.499651" @default.
• W4285594286 hasPublicationYear "2022" @default.
• W4285594286 type Work @default.
• W4285594286 citedByCount "0" @default.
• W4285594286 crossrefType "posted-content" @default.
• W4285594286 hasAuthorship W4285594286A5004098646 @default.
• W4285594286 hasAuthorship W4285594286A5007067690 @default.
• W4285594286 hasAuthorship W4285594286A5018743839 @default.
• W4285594286 hasAuthorship W4285594286A5022382160 @default.
• W4285594286 hasAuthorship W4285594286A5024131822 @default.
• W4285594286 hasAuthorship W4285594286A5031404818 @default.
• W4285594286 hasAuthorship W4285594286A5041043006 @default.
• W4285594286 hasAuthorship W4285594286A5042084472 @default.
• W4285594286 hasAuthorship W4285594286A5046233154 @default.
• W4285594286 hasAuthorship W4285594286A5047989462 @default.
• W4285594286 hasAuthorship W4285594286A5077457004 @default.
• W4285594286 hasAuthorship W4285594286A5085617980 @default.
• W4285594286 hasAuthorship W4285594286A5085731370 @default.
• W4285594286 hasAuthorship W4285594286A5087183170 @default.
• W4285594286 hasAuthorship W4285594286A5089580435 @default.
• W4285594286 hasBestOaLocation W42855942861 @default.
• W4285594286 hasConcept C104317684 @default.
• W4285594286 hasConcept C159047783 @default.
• W4285594286 hasConcept C185592680 @default.
• W4285594286 hasConcept C207001950 @default.
• W4285594286 hasConcept C25602115 @default.
• W4285594286 hasConcept C54355233 @default.
• W4285594286 hasConcept C55493867 @default.
• W4285594286 hasConcept C86803240 @default.
• W4285594286 hasConcept C95444343 @default.
• W4285594286 hasConceptScore W4285594286C104317684 @default.
• W4285594286 hasConceptScore W4285594286C159047783 @default.
• W4285594286 hasConceptScore W4285594286C185592680 @default.
• W4285594286 hasConceptScore W4285594286C207001950 @default.
• W4285594286 hasConceptScore W4285594286C25602115 @default.
• W4285594286 hasConceptScore W4285594286C54355233 @default.
• W4285594286 hasConceptScore W4285594286C55493867 @default.
• W4285594286 hasConceptScore W4285594286C86803240 @default.
• W4285594286 hasConceptScore W4285594286C95444343 @default.
• W4285594286 hasLocation W42855942861 @default.

• next