Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285596295> ?p ?o ?g. }
- W4285596295 endingPage "1462" @default.
- W4285596295 startingPage "1462" @default.
- W4285596295 abstract "Aggregation resulting from the self-association of peptide molecules remains a major challenge during preformulation. Whereas certain organic solvents are known to promote aggregation, ethanol (EtOH) is capable of disrupting interactions between peptide molecules. It is unclear whether it is beneficial or counterproductive to include EtOH in formulations of short peptides. Here, we employed molecular dynamics simulations using the DAFT protocol and MARTINI force field to predict the formation of self-associated dimers and to estimate the stability of a GLP-1-like peptide (G48) in 0–80% aqueous EtOH solutions. Both simulation and experimental data reveal that EtOH leads to a remarkable increase in the conformational stability of the peptide when stored over 15 days at 27 °C. In the absence of EtOH, dimerisation and subsequent loss in conformational stability (α-helix → random coil) were observed. EtOH improved conformational stability by reducing peptide–peptide interactions. The data suggest that a more nuanced approach may be applied in formulation decision making and, if the native state of the peptide is an α-helix organic solvent, such as EtOH, may enhance stability and improve prospects of long-term storage." @default.
- W4285596295 created "2022-07-16" @default.
- W4285596295 creator A5021137844 @default.
- W4285596295 creator A5021315844 @default.
- W4285596295 creator A5027542201 @default.
- W4285596295 creator A5046685426 @default.
- W4285596295 creator A5060355775 @default.
- W4285596295 creator A5073999918 @default.
- W4285596295 date "2022-07-14" @default.
- W4285596295 modified "2023-09-27" @default.
- W4285596295 title "Computational and Experimental Evaluation of the Stability of a GLP-1-like Peptide in Ethanol–Water Mixtures" @default.
- W4285596295 cites W1031578623 @default.
- W4285596295 cites W1588979652 @default.
- W4285596295 cites W1830439177 @default.
- W4285596295 cites W1970898345 @default.
- W4285596295 cites W1994809597 @default.
- W4285596295 cites W2002800136 @default.
- W4285596295 cites W2006570293 @default.
- W4285596295 cites W2010462701 @default.
- W4285596295 cites W2011971929 @default.
- W4285596295 cites W2016384120 @default.
- W4285596295 cites W2024895112 @default.
- W4285596295 cites W2029667189 @default.
- W4285596295 cites W2030947664 @default.
- W4285596295 cites W2035266068 @default.
- W4285596295 cites W2040231456 @default.
- W4285596295 cites W2049286183 @default.
- W4285596295 cites W2051864856 @default.
- W4285596295 cites W2052900362 @default.
- W4285596295 cites W2053271137 @default.
- W4285596295 cites W2055463345 @default.
- W4285596295 cites W2057477511 @default.
- W4285596295 cites W2066155018 @default.
- W4285596295 cites W2067258309 @default.
- W4285596295 cites W2072163112 @default.
- W4285596295 cites W2076793660 @default.
- W4285596295 cites W2077662574 @default.
- W4285596295 cites W2081077842 @default.
- W4285596295 cites W2082908456 @default.
- W4285596295 cites W2104571730 @default.
- W4285596295 cites W2119267663 @default.
- W4285596295 cites W2125482831 @default.
- W4285596295 cites W2128295473 @default.
- W4285596295 cites W2150109193 @default.
- W4285596295 cites W2156330822 @default.
- W4285596295 cites W2159458871 @default.
- W4285596295 cites W2170711116 @default.
- W4285596295 cites W2314292783 @default.
- W4285596295 cites W2316981852 @default.
- W4285596295 cites W2317708077 @default.
- W4285596295 cites W2321463817 @default.
- W4285596295 cites W2321938064 @default.
- W4285596295 cites W2346757956 @default.
- W4285596295 cites W2405075761 @default.
- W4285596295 cites W2724823461 @default.
- W4285596295 cites W2768114066 @default.
- W4285596295 cites W2936076661 @default.
- W4285596295 cites W4281843322 @default.
- W4285596295 doi "https://doi.org/10.3390/pharmaceutics14071462" @default.
- W4285596295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35890357" @default.
- W4285596295 hasPublicationYear "2022" @default.
- W4285596295 type Work @default.
- W4285596295 citedByCount "0" @default.
- W4285596295 crossrefType "journal-article" @default.
- W4285596295 hasAuthorship W4285596295A5021137844 @default.
- W4285596295 hasAuthorship W4285596295A5021315844 @default.
- W4285596295 hasAuthorship W4285596295A5027542201 @default.
- W4285596295 hasAuthorship W4285596295A5046685426 @default.
- W4285596295 hasAuthorship W4285596295A5060355775 @default.
- W4285596295 hasAuthorship W4285596295A5073999918 @default.
- W4285596295 hasBestOaLocation W42855962951 @default.
- W4285596295 hasConcept C12554922 @default.
- W4285596295 hasConcept C133571119 @default.
- W4285596295 hasConcept C147597530 @default.
- W4285596295 hasConcept C178790620 @default.
- W4285596295 hasConcept C184651966 @default.
- W4285596295 hasConcept C185592680 @default.
- W4285596295 hasConcept C18903297 @default.
- W4285596295 hasConcept C21951064 @default.
- W4285596295 hasConcept C2778530040 @default.
- W4285596295 hasConcept C2779281246 @default.
- W4285596295 hasConcept C2779965526 @default.
- W4285596295 hasConcept C2780161600 @default.
- W4285596295 hasConcept C2780471494 @default.
- W4285596295 hasConcept C32909587 @default.
- W4285596295 hasConcept C34349673 @default.
- W4285596295 hasConcept C55493867 @default.
- W4285596295 hasConcept C59593255 @default.
- W4285596295 hasConcept C71240020 @default.
- W4285596295 hasConcept C86803240 @default.
- W4285596295 hasConceptScore W4285596295C12554922 @default.
- W4285596295 hasConceptScore W4285596295C133571119 @default.
- W4285596295 hasConceptScore W4285596295C147597530 @default.
- W4285596295 hasConceptScore W4285596295C178790620 @default.
- W4285596295 hasConceptScore W4285596295C184651966 @default.
- W4285596295 hasConceptScore W4285596295C185592680 @default.
- W4285596295 hasConceptScore W4285596295C18903297 @default.
- W4285596295 hasConceptScore W4285596295C21951064 @default.