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- W4285596993 endingPage "486" @default.
- W4285596993 startingPage "486" @default.
- W4285596993 abstract "Mesaconitine (MA), one of the main diterpenoid alkaloids in Aconitum, has a variety of pharmacological effects, such as analgesia, anti-inflammation and relaxation of rat aorta. However, MA is a highly toxic ingredient. At present, studies on its toxicity are mainly focused on the heart and central nervous system, and there are few reports on the hepatotoxic mechanism of MA. Therefore, we evaluated the effects of MA administration on liver. SD rats were randomly divided into a normal saline (NS) group, a low-dose MA group (0.8 mg/kg/day) and a high-dose MA group (1.2 mg/kg/day). After 6 days of administration, the toxicity of MA on the liver was observed. Metabolomic and network toxicology methods were combined to explore the effect of MA on the liver of SD rats and the mechanism of hepatotoxicity in this study. Through metabonomics study, the differential metabolites of MA, such as L-phenylalanine, retinyl ester, L-proline and 5-hydroxyindole acetaldehyde, were obtained, which involved amino acid metabolism, vitamin metabolism, glucose metabolism and lipid metabolism. Based on network toxicological analysis, MA can affect HIF-1 signal pathway, MAPK signal pathway, PI3K-Akt signal pathway and FoxO signal pathway by regulating ALB, AKT1, CASP3, IL2 and other targets. Western blot results showed that protein expression of HMOX1, IL2 and caspase-3 in liver significantly increased after MA administration (p < 0.05). Combined with the results of metabonomics and network toxicology, it is suggested that MA may induce hepatotoxicity by activating oxidative stress, initiating inflammatory reaction and inducing apoptosis." @default.
- W4285596993 created "2022-07-16" @default.
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- W4285596993 date "2022-07-14" @default.
- W4285596993 modified "2023-10-18" @default.
- W4285596993 title "Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network" @default.
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- W4285596993 cites W1805013601 @default.
- W4285596993 cites W1852807501 @default.
- W4285596993 cites W1967478279 @default.
- W4285596993 cites W1975315649 @default.
- W4285596993 cites W1981252241 @default.
- W4285596993 cites W1997521253 @default.
- W4285596993 cites W1999800131 @default.
- W4285596993 cites W2007897725 @default.
- W4285596993 cites W2010817360 @default.
- W4285596993 cites W2016057875 @default.
- W4285596993 cites W2023627475 @default.
- W4285596993 cites W2024407138 @default.
- W4285596993 cites W2028348804 @default.
- W4285596993 cites W2033613405 @default.
- W4285596993 cites W2033676376 @default.
- W4285596993 cites W2052317856 @default.
- W4285596993 cites W2054204577 @default.
- W4285596993 cites W2070138251 @default.
- W4285596993 cites W2089827602 @default.
- W4285596993 cites W2091658147 @default.
- W4285596993 cites W2106769277 @default.
- W4285596993 cites W2106870605 @default.
- W4285596993 cites W2115038957 @default.
- W4285596993 cites W2130529820 @default.
- W4285596993 cites W2162286507 @default.
- W4285596993 cites W2169471681 @default.
- W4285596993 cites W2292749185 @default.
- W4285596993 cites W2553438861 @default.
- W4285596993 cites W2597197490 @default.
- W4285596993 cites W26935486 @default.
- W4285596993 cites W2755231468 @default.
- W4285596993 cites W2767449807 @default.
- W4285596993 cites W2887837540 @default.
- W4285596993 cites W2900255600 @default.
- W4285596993 cites W2947542891 @default.
- W4285596993 cites W2951055722 @default.
- W4285596993 cites W2972239797 @default.
- W4285596993 cites W2972439814 @default.
- W4285596993 cites W2982548397 @default.
- W4285596993 cites W2986770404 @default.
- W4285596993 cites W2989927986 @default.
- W4285596993 cites W2995633825 @default.
- W4285596993 cites W3037095850 @default.
- W4285596993 cites W3037452815 @default.
- W4285596993 cites W3039907757 @default.
- W4285596993 cites W3046500173 @default.
- W4285596993 cites W3058216959 @default.
- W4285596993 cites W3080803337 @default.
- W4285596993 cites W3081326639 @default.
- W4285596993 cites W3081679786 @default.
- W4285596993 cites W3089312208 @default.
- W4285596993 cites W3092018628 @default.
- W4285596993 cites W3095067082 @default.
- W4285596993 cites W3106623983 @default.
- W4285596993 cites W3118986501 @default.
- W4285596993 cites W3122461575 @default.
- W4285596993 cites W3124164997 @default.
- W4285596993 cites W3149885324 @default.
- W4285596993 cites W3154566785 @default.
- W4285596993 cites W3157871337 @default.
- W4285596993 cites W3162585090 @default.
- W4285596993 cites W3177289291 @default.
- W4285596993 cites W4206654541 @default.
- W4285596993 cites W4206740721 @default.
- W4285596993 cites W4206985402 @default.
- W4285596993 cites W4220813852 @default.
- W4285596993 cites W4220845226 @default.
- W4285596993 cites W4220872525 @default.
- W4285596993 cites W4224314288 @default.
- W4285596993 cites W4225416395 @default.
- W4285596993 cites W4229704949 @default.
- W4285596993 cites W4313379129 @default.
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- W4285596993 doi "https://doi.org/10.3390/toxins14070486" @default.
- W4285596993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35878224" @default.
- W4285596993 hasPublicationYear "2022" @default.
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