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- W4285596994 endingPage "866" @default.
- W4285596994 startingPage "866" @default.
- W4285596994 abstract "Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates phosphotyrosine residues and is an important regulator of several signaling pathways, such as insulin, leptin, and the ErbB signaling network, among others. Therefore, this enzyme is considered an attractive target to design new drugs against type 2 diabetes, obesity, and cancer. To date, a wide variety of PTP1B inhibitors that have been developed by experimental and computational approaches. In this review, we summarize the achievements with respect to PTP1B inhibitors discovered by applying computer-assisted drug design methodologies (virtual screening, molecular docking, pharmacophore modeling, and quantitative structure–activity relationships (QSAR)) as the principal strategy, in cooperation with experimental approaches, covering articles published from the beginning of the century until the time this review was submitted, with a focus on studies conducted with the aim of discovering new drugs against type 2 diabetes. This review encourages the use of computational techniques and includes helpful information that increases the knowledge generated to date about PTP1B inhibition, with a positive impact on the route toward obtaining a new drug against type 2 diabetes with PTP1B as a molecular target." @default.
- W4285596994 created "2022-07-16" @default.
- W4285596994 creator A5001728144 @default.
- W4285596994 creator A5030485223 @default.
- W4285596994 creator A5038219998 @default.
- W4285596994 creator A5044401843 @default.
- W4285596994 creator A5047441507 @default.
- W4285596994 creator A5047998499 @default.
- W4285596994 creator A5055277491 @default.
- W4285596994 date "2022-07-14" @default.
- W4285596994 modified "2023-10-18" @default.
- W4285596994 title "Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century" @default.
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