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- W4285603295 endingPage "104764" @default.
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- W4285603295 abstract "The link between CD4+ T and B cells during immune responses to DENV and ZIKV and their roles in cross-protection during heterologous infection is an active area of research. Here we used CD4+ lymphocyte depletions to dissect the impact of cellular immunity on humoral responses during a tertiary flavivirus infection in macaques. We show that CD4+ depletion in DENV/ZIKV-primed animals followed by DENV resulted in dysregulated adaptive immune responses. We show a delay in DENV-specific IgM/IgG antibody titers and binding and neutralization in the DENV/ZIKV-primed CD4-depleted animals but not in ZIKV/DENV-primed CD4-depleted animals. This study confirms the critical role of CD4+ cells in priming an early effective humoral response during sequential flavivirus infections. Our work here suggests that the order of flavivirus exposure affects the outcome of a tertiary infection. Our findings have implications for understanding the complex flavivirus immune responses and for the development of effective flavivirus vaccines." @default.
- W4285603295 created "2022-07-16" @default.
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- W4285603295 date "2022-08-01" @default.
- W4285603295 modified "2023-10-18" @default.
- W4285603295 title "Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure" @default.
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- W4285603295 doi "https://doi.org/10.1016/j.isci.2022.104764" @default.
- W4285603295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35982798" @default.