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- W4285603419 endingPage "20220012" @default.
- W4285603419 startingPage "20220012" @default.
- W4285603419 abstract "Municipal solid waste (MSW) landfill is one of the most important reservoirs of antimicrobial resistance (AMR) in urban environments. By reviewing ~120 published cases worldwide, we found that leachate-borne antibiotics were at the μg/L level, and meanwhile, around 8 tons of antibiotics (including the clinically relevant ones) annually leached from the MSW landfills in China. During a decade-long landfilling process, the leachate-borne bacteria mainly originating from human-associated waste (>40%) formed a community network being versatile to the drastic environmental changes. Among them, the keystone species (<italic>Proteobacteria</italic> subtaxa) functioned for metabolizing the most available substrate in leachates and were also the hosts of mobile antibiotic resistance genes (ARGs), which suggested the enduring and close associations between bacterial community and resistome. These leachate-borne ARGs were highly mobile via plasmid-mediated horizontal gene transfer, especially in less aged leachates (<10 yr). MetaCompare showed that the AMR-hazard index of landfill-specific airborne particles (index=20.5) was significantly higher than that of drinking water (index=17.81, <italic>P</italic><0.01). Human daily exposure of ARGs amounted to an inhalation of (5.83±0.16)×10<sup>5</sup> copies of ARGs, being tenfold higher than that ingestion of drinking water, which implies landfills as a non-ignorable AMR source." @default.
- W4285603419 created "2022-07-16" @default.
- W4285603419 creator A5000429333 @default.
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- W4285603419 creator A5084413654 @default.
- W4285603419 date "2022-07-01" @default.
- W4285603419 modified "2023-09-26" @default.
- W4285603419 title "Uncover landfilled antimicrobial resistance: a critical review of antibiotics flux, resistome dynamics and risk assessment" @default.
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- W4285603419 doi "https://doi.org/10.1360/nso/20220012" @default.
- W4285603419 hasPublicationYear "2022" @default.
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