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- W4285603464 abstract "Due to high TIFP caused by blocked lymphatic reflux, nanomedicine delivery is restricted in the depth of tumors. In our previous work, we demonstrated an anticipated strategy of hydrodynamic therapy by photocatalytic water splitting to reduce TIFP, which enhances delivery efficiency and antitumor efficacy. Herein, we designed a novel nanomedicine ([email protected]) as “nano-lymphatic vessels” for enhancing intratumoral delivery by coupling piezo-photocatalysis. The piezocatalysis was coupled with in situ photocatalysis to achieve higher rate (56.42 μL·h−1·g−1), which leads to the decrease of TIFP by 53.62 %. Then, the blood perfusion was drastically increased, which improved the tumor accumulation by 18.78 times compared to that of nanomedicine without water splitting. Furthermore, ROS and Pt (II) have the potent activities for tumor elimination. This strategy provides a deeper insight into coupling piezo-photocatalytic water splitting for reducing TIFP and enhancing intratumoral delivery, which opens up a new direction of nano-catalysis medicine." @default.
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- W4285603464 date "2022-12-01" @default.
- W4285603464 modified "2023-10-17" @default.
- W4285603464 title "Coupling piezo-photocatalysis to imitate lymphoid reflux for enhancing antitumor hydrodynamics therapy" @default.
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- W4285603464 doi "https://doi.org/10.1016/j.cej.2022.137981" @default.
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