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- W4285604431 endingPage "133680" @default.
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- W4285604431 abstract "Ferritin nanocages are promising nanocarriers for food bioactive compound delivery, but gastrointestinal barriers including disassociation by environmental acidity, degradation by protease, pose great challenges for cargo delivery. Herein, a self-protective ferritin that can cross gastrointestinal barriers is prepared through phosphorylation modification at 37 °C for 4 h. The results showed that the conjugation of phosphate group facilitates an acidic pI shift of ferritin from ∼5.0 to ∼4.0, allowing fast aggregation and precipitation in an intact spherical form rather than disassociation into subunits in acidic environments. Meanwhile, after incubation at simulated gastric juice for 30 min, almost 80 % STP-MjFer is retained, thus, the aggregation state and phosphate layers can improve its digestive stability. Besides, curcumin can be encapsulated within its cavity and the retention rate is ∼ 9 times higher than that of MjFer nanocage in simulated gastrointestinal fluid. Overall, the self-protective ferritin nanocarrier displays great potential for cargo delivery in food science." @default.
- W4285604431 created "2022-07-16" @default.
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- W4285604431 date "2022-12-01" @default.
- W4285604431 modified "2023-10-15" @default.
- W4285604431 title "The construction of self-protective ferritin nanocage to cross dynamic gastrointestinal barriers with improved delivery efficiency" @default.
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- W4285604431 doi "https://doi.org/10.1016/j.foodchem.2022.133680" @default.
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