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• W4285604847 endingPage "148595" @default.
• W4285604847 startingPage "148595" @default.
• W4285604847 abstract "The cytochrome c oxidase complex, complex VI (CIV), catalyzes the terminal step of the mitochondrial electron transport chain where the reduction of oxygen to water by cytochrome c is coupled to the generation of a protonmotive force that drive the synthesis of ATP. CIV evolution was greatly accelerated in humans and other anthropoid primates and appears to be driven by adaptive selection. However, it is not known if there are significant functional differences between the anthropoid primates CIV, and other mammals. Comparison of the high-resolution structures of bovine CIV, mouse CIV and human CIV shows structural differences that are associated with anthropoid-specific substitutions. Here I examine the possible effects of these substitutions in four CIV peptides that are known to affect proton pumping: the mtDNA-coded subunits I, II and III, and the nuclear-encoded subunit VIa2. I conclude that many of the anthropoid-specific substitutions could be expected to modulate the rate and/or the efficiency of proton pumping. These results are compatible with the previously proposed hypothesis that the accelerated evolution of CIV in anthropoid primates is driven by selection pressure to lower the mitochondrial protonmotive force and thus decrease the rate of superoxide generation by mitochondria." @default.
• W4285604847 created "2022-07-16" @default.
• W4285604847 creator A5037068560 @default.
• W4285604847 date "2022-11-01" @default.
• W4285604847 modified "2023-10-17" @default.
• W4285604847 title "The accelerated evolution of human cytochrome c oxidase – Selection for reduced rate and proton pumping efficiency?" @default.
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• W4285604847 doi "https://doi.org/10.1016/j.bbabio.2022.148595" @default.
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