FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285604883> ?p ?o ?g. }

• W4285604883 endingPage "961" @default.
• W4285604883 startingPage "944" @default.
• W4285604883 abstract "Current regulatory T cell (Treg)-targeted therapies exhibit clinical benefit, highlighting the importance of targeting Tregs in cancer. Understanding Treg biology, recruitment, and stabilization within the tumor microenvironment (TME) may provide enhanced cancer therapeutic opportunities to target Tregs without perturbing effector T cell function or immune homeostasis. Multi-omics approaches combining novel computational tools may help define the complex gene regulatory networks that modulate Treg function and identify biomarkers that define functionally suppressive regulatory T cell subpopulations within the TME. The success of immunotherapy in oncology underscores the vital role of the immune system in cancer development. Regulatory T cells (Tregs) maintain a fine balance between autoimmunity and immune suppression. They have multiple roles in the tumor microenvironment (TME) but act particularly in suppressing T cell activation. This review focuses on the detrimental and sometimes beneficial roles of Tregs in tumors, our current understanding of recruitment and stabilization of Tregs within the TME, and current Treg-targeted therapeutics. Research identifying subpopulations of Tregs and their respective functions and interactions within the complex networks of the TME will be crucial to develop the next generation of immunotherapies. Through these advances, Treg-targeted immunotherapy could have important implications for the future of oncology. The success of immunotherapy in oncology underscores the vital role of the immune system in cancer development. Regulatory T cells (Tregs) maintain a fine balance between autoimmunity and immune suppression. They have multiple roles in the tumor microenvironment (TME) but act particularly in suppressing T cell activation. This review focuses on the detrimental and sometimes beneficial roles of Tregs in tumors, our current understanding of recruitment and stabilization of Tregs within the TME, and current Treg-targeted therapeutics. Research identifying subpopulations of Tregs and their respective functions and interactions within the complex networks of the TME will be crucial to develop the next generation of immunotherapies. Through these advances, Treg-targeted immunotherapy could have important implications for the future of oncology." @default.
• W4285604883 created "2022-07-16" @default.
• W4285604883 creator A5001000053 @default.
• W4285604883 creator A5008106149 @default.
• W4285604883 creator A5044898944 @default.
• W4285604883 creator A5057993946 @default.
• W4285604883 creator A5063843417 @default.
• W4285604883 date "2022-11-01" @default.
• W4285604883 modified "2023-10-18" @default.
• W4285604883 title "Therapeutic targeting of regulatory T cells in cancer" @default.
• W4285604883 cites W1486722793 @default.
• W4285604883 cites W1499979791 @default.
• W4285604883 cites W1503997891 @default.
• W4285604883 cites W1555993773 @default.
• W4285604883 cites W1564728191 @default.
• W4285604883 cites W1883117256 @default.
• W4285604883 cites W1895474562 @default.
• W4285604883 cites W1940241680 @default.
• W4285604883 cites W1941651450 @default.
• W4285604883 cites W1963665993 @default.
• W4285604883 cites W1963688245 @default.
• W4285604883 cites W1964389846 @default.
• W4285604883 cites W1966922635 @default.
• W4285604883 cites W1967029979 @default.
• W4285604883 cites W1970666336 @default.
• W4285604883 cites W1972042093 @default.
• W4285604883 cites W1973647796 @default.
• W4285604883 cites W1974140746 @default.
• W4285604883 cites W1979533843 @default.
• W4285604883 cites W1980040544 @default.
• W4285604883 cites W1982395758 @default.
• W4285604883 cites W1983812780 @default.
• W4285604883 cites W1984650310 @default.
• W4285604883 cites W1984909066 @default.
• W4285604883 cites W1989712167 @default.
• W4285604883 cites W1990295999 @default.
• W4285604883 cites W1991748190 @default.
• W4285604883 cites W1993211204 @default.
• W4285604883 cites W1994850185 @default.
• W4285604883 cites W1995877369 @default.
• W4285604883 cites W2002994195 @default.
• W4285604883 cites W2005591752 @default.
• W4285604883 cites W2007631222 @default.
• W4285604883 cites W2008609052 @default.
• W4285604883 cites W2016953305 @default.
• W4285604883 cites W2021249461 @default.
• W4285604883 cites W2028676290 @default.
• W4285604883 cites W2030820156 @default.
• W4285604883 cites W2033330275 @default.
• W4285604883 cites W2035279824 @default.
• W4285604883 cites W2036338097 @default.
• W4285604883 cites W2036881989 @default.
• W4285604883 cites W2037034595 @default.
• W4285604883 cites W2039855270 @default.
• W4285604883 cites W2041557663 @default.
• W4285604883 cites W2044091978 @default.
• W4285604883 cites W2045570438 @default.
• W4285604883 cites W2046609236 @default.
• W4285604883 cites W2046847486 @default.
• W4285604883 cites W2049553585 @default.
• W4285604883 cites W2050149895 @default.
• W4285604883 cites W2052329251 @default.
• W4285604883 cites W2054738595 @default.
• W4285604883 cites W2056138805 @default.
• W4285604883 cites W2058887247 @default.
• W4285604883 cites W2060140038 @default.
• W4285604883 cites W2063241227 @default.
• W4285604883 cites W2063503734 @default.
• W4285604883 cites W2063882298 @default.
• W4285604883 cites W2064777995 @default.
• W4285604883 cites W2066671159 @default.
• W4285604883 cites W2067509468 @default.
• W4285604883 cites W2074699765 @default.
• W4285604883 cites W2076537509 @default.
• W4285604883 cites W2076952890 @default.
• W4285604883 cites W2078439148 @default.
• W4285604883 cites W2078448383 @default.
• W4285604883 cites W2080181628 @default.
• W4285604883 cites W2082099294 @default.
• W4285604883 cites W2086595653 @default.
• W4285604883 cites W2091365300 @default.
• W4285604883 cites W2093608608 @default.
• W4285604883 cites W2095301728 @default.
• W4285604883 cites W2096151993 @default.
• W4285604883 cites W2096625946 @default.
• W4285604883 cites W2097811455 @default.
• W4285604883 cites W2097995306 @default.
• W4285604883 cites W2098969957 @default.
• W4285604883 cites W2099738485 @default.
• W4285604883 cites W2099854994 @default.
• W4285604883 cites W2100228832 @default.
• W4285604883 cites W2100474263 @default.
• W4285604883 cites W2101581360 @default.
• W4285604883 cites W2102202232 @default.
• W4285604883 cites W2102537478 @default.
• W4285604883 cites W2105459360 @default.
• W4285604883 cites W2106190040 @default.
• W4285604883 cites W2106728539 @default.

• next