Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285605648> ?p ?o ?g. }
- W4285605648 endingPage "104762" @default.
- W4285605648 startingPage "104762" @default.
- W4285605648 abstract "Although astrocytes are involved in the pathogenesis of CNS diseases, how they induce synaptic abnormalities is unclear. Currently, in vitro pathological astrocyte cultures or animal models do not reproduce human disease phenotypes accurately. Induced pluripotent stem cells (iPSCs) are replacing animal models in pathological studies. We developed an autaptic culture (AC) system containing single neuron cultures grown on microislands of astrocytes. AC with human iPSC-derived astrocytes (HiA) was established. We evaluated the effect of astrocytes on the synaptic functions of human-derived neurons. We found a significantly higher Na+ current amplitude, membrane capacitance, and number of synapses, as well as longer dendrites, in HiAACs compared with neuron monocultures. Furthermore, HiAs were involved in the formation and maturation of functional synapses that exhibited excitatory postsynaptic currents. This system can facilitate the study of CNS diseases and advance the development of drugs targeting glial cells." @default.
- W4285605648 created "2022-07-16" @default.
- W4285605648 creator A5007014949 @default.
- W4285605648 creator A5035058143 @default.
- W4285605648 creator A5039503254 @default.
- W4285605648 creator A5050896634 @default.
- W4285605648 creator A5053082078 @default.
- W4285605648 creator A5056491345 @default.
- W4285605648 creator A5068354501 @default.
- W4285605648 creator A5071140861 @default.
- W4285605648 date "2022-08-01" @default.
- W4285605648 modified "2023-10-14" @default.
- W4285605648 title "Establishment of autaptic culture with human-induced pluripotent stem cell-derived astrocytes" @default.
- W4285605648 cites W1588361932 @default.
- W4285605648 cites W1967804600 @default.
- W4285605648 cites W1971125401 @default.
- W4285605648 cites W1973477241 @default.
- W4285605648 cites W1987700551 @default.
- W4285605648 cites W1993665150 @default.
- W4285605648 cites W2008986992 @default.
- W4285605648 cites W2009867508 @default.
- W4285605648 cites W2015061624 @default.
- W4285605648 cites W2034038906 @default.
- W4285605648 cites W2059994807 @default.
- W4285605648 cites W2068684244 @default.
- W4285605648 cites W2069498125 @default.
- W4285605648 cites W2072389508 @default.
- W4285605648 cites W2076324460 @default.
- W4285605648 cites W2084566588 @default.
- W4285605648 cites W2087151465 @default.
- W4285605648 cites W2093659265 @default.
- W4285605648 cites W2107667281 @default.
- W4285605648 cites W2123292451 @default.
- W4285605648 cites W2138977668 @default.
- W4285605648 cites W2146249493 @default.
- W4285605648 cites W2147372806 @default.
- W4285605648 cites W2152460583 @default.
- W4285605648 cites W2191292005 @default.
- W4285605648 cites W2268962324 @default.
- W4285605648 cites W2333890525 @default.
- W4285605648 cites W2611225933 @default.
- W4285605648 cites W2616733389 @default.
- W4285605648 cites W2622214442 @default.
- W4285605648 cites W2745848953 @default.
- W4285605648 cites W2763925266 @default.
- W4285605648 cites W2765155499 @default.
- W4285605648 cites W2765965004 @default.
- W4285605648 cites W2772969939 @default.
- W4285605648 cites W2786430800 @default.
- W4285605648 cites W2887980327 @default.
- W4285605648 cites W2898424850 @default.
- W4285605648 cites W2916001803 @default.
- W4285605648 cites W2917543658 @default.
- W4285605648 cites W2923674090 @default.
- W4285605648 cites W2945966817 @default.
- W4285605648 cites W2946268805 @default.
- W4285605648 cites W2948665150 @default.
- W4285605648 cites W2951866836 @default.
- W4285605648 cites W2962876681 @default.
- W4285605648 cites W2966781108 @default.
- W4285605648 cites W3022859098 @default.
- W4285605648 cites W3033600828 @default.
- W4285605648 cites W3039473091 @default.
- W4285605648 cites W3045413893 @default.
- W4285605648 cites W3110935809 @default.
- W4285605648 cites W3161561112 @default.
- W4285605648 cites W3162580900 @default.
- W4285605648 doi "https://doi.org/10.1016/j.isci.2022.104762" @default.
- W4285605648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35942096" @default.
- W4285605648 hasPublicationYear "2022" @default.
- W4285605648 type Work @default.
- W4285605648 citedByCount "0" @default.
- W4285605648 crossrefType "journal-article" @default.
- W4285605648 hasAuthorship W4285605648A5007014949 @default.
- W4285605648 hasAuthorship W4285605648A5035058143 @default.
- W4285605648 hasAuthorship W4285605648A5039503254 @default.
- W4285605648 hasAuthorship W4285605648A5050896634 @default.
- W4285605648 hasAuthorship W4285605648A5053082078 @default.
- W4285605648 hasAuthorship W4285605648A5056491345 @default.
- W4285605648 hasAuthorship W4285605648A5068354501 @default.
- W4285605648 hasAuthorship W4285605648A5071140861 @default.
- W4285605648 hasBestOaLocation W42856056481 @default.
- W4285605648 hasConcept C104317684 @default.
- W4285605648 hasConcept C107459253 @default.
- W4285605648 hasConcept C112592302 @default.
- W4285605648 hasConcept C136834591 @default.
- W4285605648 hasConcept C145103041 @default.
- W4285605648 hasConcept C169760540 @default.
- W4285605648 hasConcept C17077164 @default.
- W4285605648 hasConcept C2777542381 @default.
- W4285605648 hasConcept C2778794669 @default.
- W4285605648 hasConcept C28328180 @default.
- W4285605648 hasConcept C529278444 @default.
- W4285605648 hasConcept C55493867 @default.
- W4285605648 hasConcept C86803240 @default.
- W4285605648 hasConcept C95444343 @default.
- W4285605648 hasConceptScore W4285605648C104317684 @default.
- W4285605648 hasConceptScore W4285605648C107459253 @default.