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• W4285605890 endingPage "213030" @default.
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• W4285605890 abstract "Nowadays, the three-dimensional (3D) printed calcium phosphate (CaP) ceramics have well-designed geometric structure, but suffer from relative weak osteoinductivity. Surface modification by incorporating bone morphogenetic protein-2 (BMP2) onto scaffolds is considered as an efficient approach to improve their bioactivity. However, high dose and uncontrolled burst release of BMP2 may cause undesired side effect. In the present study, porous BCP ceramics with inverse face-centred cube structure prepared by digital light processing (DLP)-based 3D printing technique were used as the substrates. BMP2 proteins were loaded in the self-assembled Heparin/PEI nanogels (NP/BMP2), and then immobilized onto BCP substrates through the intermediate mussel-derived bioactive dopamine and dihydroxyphenylacetic acid (DA/DOPAC) coating layers to construct functional BCP/layer/NP/BMP2 scaffolds. Our results showed that Heparin/PEI nanogel was a potent delivery system for BMP2, and BCP/layer/NP/BMP2 scaffolds exhibited the high loading capacity, controlled release rate, and sustained local delivery of BMP2. In vitro cell experiments with bone marrow stromal cells (BMSCs) found that BCP/layer/NP/BMP2 could promote cell proliferation, facilitate cell spreading, accelerate cell migration, up-regulate expression of osteogenic genes, and improve synthesis of osteoblast-related proteins. Moreover, the murine intramuscular implantation model suggested that BCP/layer/NP/BMP2 had a superior osteoinductive capacity, and the rat femoral condyle defect repair model showed that BCP/layer/NP/BMP2 could enhance in situ bone repair and regeneration. These findings demonstrate that the incorporation of BMP2 loaded Heparin/PEI nanogels to 3D printed scaffolds holds great promise in fabricating bone graft with a superior biological performance for orthopedic application. • Functional BCP/layer/NP/BMP2 scaffolds were fabricated by incorporating BMP2-loaded self-assembled Heparin/PEI nanogels to 3D printed BCP substrates. • The bioactive dopamine and dihydroxyphenylacetic acid coating layer was beneficial for the immobilization of nanogels onto ceramic surface. • The self-assembled Heparin/PEI nanogel could serve as an effective delivery system for bioactive factors like BMP2. • BCP/layer/NP/BMP2 scaffolds with sustained local delivery of BMP2 showed good osteoinductive and osteogenic capacities." @default.
• W4285605890 created "2022-07-16" @default.
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• W4285605890 date "2022-09-01" @default.
• W4285605890 modified "2023-09-25" @default.
• W4285605890 title "Dopamine/DOPAC-assisted immobilization of bone morphogenetic protein-2 loaded Heparin/PEI nanogels onto three-dimentional printed calcium phosphate ceramics for enhanced osteoinductivity and osteogenicity" @default.
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• W4285605890 doi "https://doi.org/10.1016/j.bioadv.2022.213030" @default.
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