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- W4285606585 abstract "The aggregation of phthalocyanines (Pcs) enfeebles their suitability as G-quadruplex (G4) ligands over time. It is hypothesized that the interfacial assembly of Pcs on graphene oxide (GO) influences intermolecular interactions, thereby affecting their physicochemical properties and inducing stabilization of Pcs in solution. Hence, the stacking of Pcs on GO could be tuned to create nanosystems with the ability to detect G4 for longer periods through a slow release of Pcs. Four cationic structurally-related zinc(II) phthalocyanines (ZnPc) were non-covalently assembled on GO by ultrasonic exfoliation. A comprehensive characterization of [email protected] was carried out by spectroscopic techniques and electron microscopy to understand the organization of ZnPcs on GO. The fluorescence of [email protected] was studied in the presence of G4 (T2G5T)4 and duplex ds26 through spectrofluorimetric titrations and monitored along time. GO induced a re-organization of the ZnPcs mostly to J-aggregates and quenched their original fluorescence up to 98 % (“turn-off”). In general, [email protected] recovered their fluorescence (“turn-on”) after the titrations and showed affinity to G4 (KD up to 1.92 μM). This is the first report that highlights the contribution of GO interfaces to assemble ZnPcs and allow their slow and controlled release to detect G4 over longer periods." @default.
- W4285606585 created "2022-07-16" @default.
- W4285606585 creator A5001845976 @default.
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- W4285606585 creator A5059502789 @default.
- W4285606585 creator A5080578017 @default.
- W4285606585 creator A5083991167 @default.
- W4285606585 date "2022-12-01" @default.
- W4285606585 modified "2023-10-16" @default.
- W4285606585 title "Interfacial assembly of zinc(II) phthalocyanines on graphene oxide (GO): Stable “turn-off-on” nanoplatforms to detect G-quadruplexes (G4)" @default.
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