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- W4285606931 endingPage "101964" @default.
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- W4285606931 abstract "Honeybee venom is a complex mixture of toxic components, including major royal jelly protein (MRJP) 8 and 9. MRJP 8 and MRJP 9 are allergens, and MRJP 8 reduces melittin-induced cell apoptosis. However, their functional roles are poorly understood, and their antimicrobial activities have not been determined. In this study, the antimicrobial role of MRJP 8 and MRJP 9 of honeybee (Apis mellifera) venom (AmMRJP 8 and AmMRJP 9) was demonstrated. The presence of AmMRJP 8 and AmMRJP 9 in the secreted venom was observed using antibodies against recombinant AmMRJP 8 and AmMRJP 9 produced in baculovirus-infected insect cells. Recombinant AmMRJP 8 and AmMRJP 9 exhibited an inhibitory activity against microbial serine proteases. Consistent with their inhibitory activity, they induced structural damage by binding to microbial surfaces, resulting in a broad-spectrum antimicrobial activity against bacteria and fungi. They had little effect on hemolysis. Therefore, AmMRJP 8 and AmMRJP 9 could function as antimicrobial agents in honeybee venom." @default.
- W4285606931 created "2022-07-16" @default.
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- W4285606931 date "2022-09-01" @default.
- W4285606931 modified "2023-10-16" @default.
- W4285606931 title "Antimicrobial activity of major royal jelly protein 8 and 9 of honeybee (Apis mellifera) venom" @default.
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- W4285606931 doi "https://doi.org/10.1016/j.aspen.2022.101964" @default.
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