FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285607575> ?p ?o ?g. }

• W4285607575 endingPage "88" @default.
• W4285607575 startingPage "79" @default.
• W4285607575 abstract "Relevance. It is known that in children the frequency of perioperative critical events due to the introduction of drugs is more than 5%. For example fentanyl, which is used as an adjunct to surgical anesthesia, is a major factor in increasing the number of deaths from opioid overdoses. Among the areas of reducing the frequency of severe adverse reactions to perioperative drugs - taking into account the pharmacogenetic variations of the patient.&#x0D; Objective is to consider current data on pharmacogenetic aspects of pharmacokinetics and pharmacodynamics of perioperative drugs.&#x0D; Methods. Analysis of the data presented in PubMed by keywords pharmacogenetics, general anesthetics, analgesics, muscle relaxants, children. Search depth – 7 years (2014-2020), with a retrospective deepening of some positions until 2002.&#x0D; Results. The pharmacogenetic aspects of the pharmacokinetics of perioperative drugs are related to the genes of the enzymes that metabolize them and their transporters. Current data on the prevalence of polymorphic alleles of CYP2C9 genes (provides metabolism of nonsteroidal anti-inflammatory and anticonvulsant drugs) and CYP2D6 (metabolizes opioids, antidepressants, antiemetics) in Europe and, in particular, in Ukraine were presented. Thus, the inactive allele CYP2C19 * 2 was found in 13%, while the allele of increased activity CYP2C19 * 17 - in 25% of the population of Ukraine; allele with lost CYP2D6 function (CYP2D6 * 4) - in 18.6% of Ukrainians. Homozygotes with CYP2C9 * 3 polymorphism metabolize nonsteroidal anti-inflammatory drugs much more slowly than wild-type carriers, which may lead to their accumulation and side effects. The analgesic effect of codeine occurs only after it is metabolized in the liver by CYP2D6 to morphine. Respiratory depression, apnea and death may occur in patients with excessive metabolic rate even after a single dose of codeine; however, was noted the ineffectiveness of ondansetron due to a decrease in its concentration in the blood in thesepatients. Concomitant use of midazolam and fentanyl may prolong the effect of fentanyl by competing metabolism of midazolam by the hepatic enzyme CYP3A4, especially in patients with low metabolism. Plasma butyrylcholinesterase deficiency reduces succinylcholine inactivation in 1 in 1,500 people. Changing the genotype of uridine diphosphate glycosyltransferase causes increased glucuronidation of morphine, which may lead to a decrease in its effectiveness. As an example of pharmacogenetic changes in pharmacodynamics can be considered malignant hyperthermia, which occurs due to exposure to volatile anesthetics and depolarizing muscle relaxants in mutations in the RYR1 gene. Carriers of the minor allele (G) of the 5HT2A rs6313 gene require less propofol and 40% less time to start induction of anesthesia.&#x0D; Conclusions. The efficacy and safety of perioperative drugs are largely related to the pharmacogenetic aspects of their pharmacokinetics, especially mutations in genes of enzymes of the metabolism. Mutations in the genes of volatile anesthetic receptors and depolarizing muscle relaxants when their used cause a risk of malignant hyperthermia. The application of pharmacogenetics is the need to titrate drugs that have significant variability of action depending on the genotype. It is advisable to avoid the use of drugs with a high risk of pharmacogenetic reactions, if other alternative drugs are available." @default.
• W4285607575 created "2022-07-16" @default.
• W4285607575 creator A5002842425 @default.
• W4285607575 creator A5020490157 @default.
• W4285607575 creator A5028405598 @default.
• W4285607575 date "2022-06-30" @default.
• W4285607575 modified "2023-10-17" @default.
• W4285607575 title "PHARMACOGENETIC ASPECTS OF THE USE OF PERIOPERATIVE DRUGS IN PEDIATRICS. Review" @default.
• W4285607575 cites W1841282597 @default.
• W4285607575 cites W1968159570 @default.
• W4285607575 cites W1999123251 @default.
• W4285607575 cites W2007474149 @default.
• W4285607575 cites W2009176168 @default.
• W4285607575 cites W2053392541 @default.
• W4285607575 cites W2091212941 @default.
• W4285607575 cites W2171577530 @default.
• W4285607575 cites W2185895351 @default.
• W4285607575 cites W2270764054 @default.
• W4285607575 cites W2523705599 @default.
• W4285607575 cites W2533187150 @default.
• W4285607575 cites W2554311649 @default.
• W4285607575 cites W2588724131 @default.
• W4285607575 cites W2595236416 @default.
• W4285607575 cites W2601036536 @default.
• W4285607575 cites W2622755760 @default.
• W4285607575 cites W2734921548 @default.
• W4285607575 cites W2783940765 @default.
• W4285607575 cites W2895401303 @default.
• W4285607575 cites W2901540172 @default.
• W4285607575 cites W2963612814 @default.
• W4285607575 cites W2964415308 @default.
• W4285607575 cites W2982205485 @default.
• W4285607575 cites W3129768662 @default.
• W4285607575 cites W4248521733 @default.
• W4285607575 doi "https://doi.org/10.32345/2664-4738.2.2022.10" @default.
• W4285607575 hasPublicationYear "2022" @default.
• W4285607575 type Work @default.
• W4285607575 citedByCount "0" @default.
• W4285607575 crossrefType "journal-article" @default.
• W4285607575 hasAuthorship W4285607575A5002842425 @default.
• W4285607575 hasAuthorship W4285607575A5020490157 @default.
• W4285607575 hasAuthorship W4285607575A5028405598 @default.
• W4285607575 hasBestOaLocation W42856075751 @default.
• W4285607575 hasConcept C104317684 @default.
• W4285607575 hasConcept C111113717 @default.
• W4285607575 hasConcept C112705442 @default.
• W4285607575 hasConcept C126322002 @default.
• W4285607575 hasConcept C135763542 @default.
• W4285607575 hasConcept C140840227 @default.
• W4285607575 hasConcept C170734499 @default.
• W4285607575 hasConcept C2777389121 @default.
• W4285607575 hasConcept C2777866328 @default.
• W4285607575 hasConcept C2780820201 @default.
• W4285607575 hasConcept C2908647359 @default.
• W4285607575 hasConcept C31174226 @default.
• W4285607575 hasConcept C33664856 @default.
• W4285607575 hasConcept C42219234 @default.
• W4285607575 hasConcept C526171541 @default.
• W4285607575 hasConcept C54355233 @default.
• W4285607575 hasConcept C55775858 @default.
• W4285607575 hasConcept C62231903 @default.
• W4285607575 hasConcept C71924100 @default.
• W4285607575 hasConcept C86803240 @default.
• W4285607575 hasConcept C98274493 @default.
• W4285607575 hasConcept C99454951 @default.
• W4285607575 hasConceptScore W4285607575C104317684 @default.
• W4285607575 hasConceptScore W4285607575C111113717 @default.
• W4285607575 hasConceptScore W4285607575C112705442 @default.
• W4285607575 hasConceptScore W4285607575C126322002 @default.
• W4285607575 hasConceptScore W4285607575C135763542 @default.
• W4285607575 hasConceptScore W4285607575C140840227 @default.
• W4285607575 hasConceptScore W4285607575C170734499 @default.
• W4285607575 hasConceptScore W4285607575C2777389121 @default.
• W4285607575 hasConceptScore W4285607575C2777866328 @default.
• W4285607575 hasConceptScore W4285607575C2780820201 @default.
• W4285607575 hasConceptScore W4285607575C2908647359 @default.
• W4285607575 hasConceptScore W4285607575C31174226 @default.
• W4285607575 hasConceptScore W4285607575C33664856 @default.
• W4285607575 hasConceptScore W4285607575C42219234 @default.
• W4285607575 hasConceptScore W4285607575C526171541 @default.
• W4285607575 hasConceptScore W4285607575C54355233 @default.
• W4285607575 hasConceptScore W4285607575C55775858 @default.
• W4285607575 hasConceptScore W4285607575C62231903 @default.
• W4285607575 hasConceptScore W4285607575C71924100 @default.
• W4285607575 hasConceptScore W4285607575C86803240 @default.
• W4285607575 hasConceptScore W4285607575C98274493 @default.
• W4285607575 hasConceptScore W4285607575C99454951 @default.
• W4285607575 hasIssue "2" @default.
• W4285607575 hasLocation W42856075751 @default.
• W4285607575 hasOpenAccess W4285607575 @default.
• W4285607575 hasPrimaryLocation W42856075751 @default.
• W4285607575 hasRelatedWork W1573559951 @default.
• W4285607575 hasRelatedWork W2047094448 @default.
• W4285607575 hasRelatedWork W2064302284 @default.
• W4285607575 hasRelatedWork W2118451906 @default.
• W4285607575 hasRelatedWork W2140460104 @default.
• W4285607575 hasRelatedWork W2470985001 @default.
• W4285607575 hasRelatedWork W2995148693 @default.

• next