FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285609523> ?p ?o ?g. }

• W4285609523 endingPage "153" @default.
• W4285609523 startingPage "153" @default.
• W4285609523 abstract "A previous bioinformatics study suggested that circular RNA 0001666 (circ_0001666) and its target microRNA (miR)-1229 were associated with colorectal cancer (CRC) pathogenesis. However, the role of this interaction in the regulation of CRC cell malignancy remains unclear. Thus, the aim of the present study was to examine the interaction between circ_0001666 and miR-1229, and its effects on CRC cell malignancy. circ_0001666 overexpression or knockdown plasmids were transfected into the HT-29 and HCT-116 cell lines. In addition, in rescue experiments, circ_000166 or miR-1229 overexpression plasmids were transfected into the HT-29 cell line, either alone or in combination. Following transfection, cell proliferation, apoptosis, invasion and the number of CD133+ cells were analyzed. The protein expression level of proteins in the Wnt/β-catenin pathway was also examined. In both HT-29 and HCT-116 cell lines, circ_0001666 overexpression increased apoptosis, whilst inhibiting cell proliferation and invasion, and reducing the frequency of CD133+ cells. By contrast, circ_0001666 knockdown reduced apoptosis, but increased cell proliferation and the number of CD133+ cells. However, cell invasion remained unaffected. In addition, circ_0001666 expression levels negatively regulated those of miR-1229, whereas miR-1229 expression did not affect circ_0001666, in both the HT-29 and HCT-116 cell lines. Furthermore, a luciferase reporter assay confirmed that miR-1229 directly bound to circ_0001666. In the HT-29 cell line, miR-1229 overexpression activated the Wnt/β-catenin pathway, and promoted cell proliferation, invasion and stemness, while suppressing cell apoptosis. In addition, miR-1229 overexpression reversed the effects of circ_0001666 overexpression. In conclusion, circ_0001666 suppresses CRC cell proliferation, invasion and stemness by inhibiting the Wnt/β-catenin signaling pathway by targeting miR-1229, and may represent a potential target for CRC treatment." @default.
• W4285609523 created "2022-07-16" @default.
• W4285609523 creator A5001554341 @default.
• W4285609523 creator A5068083936 @default.
• W4285609523 creator A5071315431 @default.
• W4285609523 creator A5086194562 @default.
• W4285609523 creator A5088969268 @default.
• W4285609523 creator A5089473346 @default.
• W4285609523 date "2022-05-01" @default.
• W4285609523 modified "2023-10-18" @default.
• W4285609523 title "Circular RNA 0001666 inhibits colorectal cancer cell proliferation, invasion and stemness by inactivating the Wnt/β-catenin signaling pathway and targeting microRNA-1229." @default.
• W4285609523 cites W1581610755 @default.
• W4285609523 cites W2015244252 @default.
• W4285609523 cites W2107277218 @default.
• W4285609523 cites W2161222316 @default.
• W4285609523 cites W2192080449 @default.
• W4285609523 cites W2332225204 @default.
• W4285609523 cites W2484161709 @default.
• W4285609523 cites W2591303105 @default.
• W4285609523 cites W2606262935 @default.
• W4285609523 cites W2621361823 @default.
• W4285609523 cites W2795546864 @default.
• W4285609523 cites W2889646458 @default.
• W4285609523 cites W2892630678 @default.
• W4285609523 cites W2900597665 @default.
• W4285609523 cites W2903870145 @default.
• W4285609523 cites W2909184366 @default.
• W4285609523 cites W2934876670 @default.
• W4285609523 cites W2965867002 @default.
• W4285609523 cites W2967458208 @default.
• W4285609523 cites W2968803027 @default.
• W4285609523 cites W2980253985 @default.
• W4285609523 cites W2982093057 @default.
• W4285609523 cites W2987654150 @default.
• W4285609523 cites W3032946224 @default.
• W4285609523 cites W3049413863 @default.
• W4285609523 cites W3092020182 @default.
• W4285609523 cites W3133888882 @default.
• W4285609523 cites W4211102638 @default.
• W4285609523 doi "https://doi.org/10.3892/ol.2022.13273" @default.
• W4285609523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35836485" @default.
• W4285609523 hasPublicationYear "2022" @default.
• W4285609523 type Work @default.
• W4285609523 citedByCount "3" @default.
• W4285609523 countsByYear W42856095232022 @default.
• W4285609523 countsByYear W42856095232023 @default.
• W4285609523 crossrefType "journal-article" @default.
• W4285609523 hasAuthorship W4285609523A5001554341 @default.
• W4285609523 hasAuthorship W4285609523A5068083936 @default.
• W4285609523 hasAuthorship W4285609523A5071315431 @default.
• W4285609523 hasAuthorship W4285609523A5086194562 @default.
• W4285609523 hasAuthorship W4285609523A5088969268 @default.
• W4285609523 hasAuthorship W4285609523A5089473346 @default.
• W4285609523 hasConcept C104317684 @default.
• W4285609523 hasConcept C137620995 @default.
• W4285609523 hasConcept C145059251 @default.
• W4285609523 hasConcept C1491633281 @default.
• W4285609523 hasConcept C153911025 @default.
• W4285609523 hasConcept C173396325 @default.
• W4285609523 hasConcept C185592680 @default.
• W4285609523 hasConcept C190283241 @default.
• W4285609523 hasConcept C2781018059 @default.
• W4285609523 hasConcept C29537977 @default.
• W4285609523 hasConcept C502942594 @default.
• W4285609523 hasConcept C54009773 @default.
• W4285609523 hasConcept C54355233 @default.
• W4285609523 hasConcept C62112901 @default.
• W4285609523 hasConcept C62478195 @default.
• W4285609523 hasConcept C81885089 @default.
• W4285609523 hasConcept C86803240 @default.
• W4285609523 hasConcept C95444343 @default.
• W4285609523 hasConceptScore W4285609523C104317684 @default.
• W4285609523 hasConceptScore W4285609523C137620995 @default.
• W4285609523 hasConceptScore W4285609523C145059251 @default.
• W4285609523 hasConceptScore W4285609523C1491633281 @default.
• W4285609523 hasConceptScore W4285609523C153911025 @default.
• W4285609523 hasConceptScore W4285609523C173396325 @default.
• W4285609523 hasConceptScore W4285609523C185592680 @default.
• W4285609523 hasConceptScore W4285609523C190283241 @default.
• W4285609523 hasConceptScore W4285609523C2781018059 @default.
• W4285609523 hasConceptScore W4285609523C29537977 @default.
• W4285609523 hasConceptScore W4285609523C502942594 @default.
• W4285609523 hasConceptScore W4285609523C54009773 @default.
• W4285609523 hasConceptScore W4285609523C54355233 @default.
• W4285609523 hasConceptScore W4285609523C62112901 @default.
• W4285609523 hasConceptScore W4285609523C62478195 @default.
• W4285609523 hasConceptScore W4285609523C81885089 @default.
• W4285609523 hasConceptScore W4285609523C86803240 @default.
• W4285609523 hasConceptScore W4285609523C95444343 @default.
• W4285609523 hasIssue "5" @default.
• W4285609523 hasLocation W42856095231 @default.
• W4285609523 hasOpenAccess W4285609523 @default.
• W4285609523 hasPrimaryLocation W42856095231 @default.
• W4285609523 hasRelatedWork W2064378035 @default.
• W4285609523 hasRelatedWork W2795752124 @default.
• W4285609523 hasRelatedWork W2899227291 @default.
• W4285609523 hasRelatedWork W2899361988 @default.
• W4285609523 hasRelatedWork W2907903807 @default.

• next