Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285613099> ?p ?o ?g. }
- W4285613099 endingPage "4320" @default.
- W4285613099 startingPage "4310" @default.
- W4285613099 abstract "Severe acute pancreatitis (SAP) is one of the most common abdominal conditions of digestive system that usually causes acute lung injury through systemic inflammation. Follistatin-like 1 (FSTL-1) has been reported to have anti-inflammatory and anti-apoptotic effects in a variety of diseases. The aim of this study was to investigate the effects of FSTL-1 on SAP-associated lung injury (SAPALI) and the underlying mechanism.SAP model was induced by intraperitoneal injection of the L-arginine in C57BL/6 mice. The haematoxylin and eosin (H&E) staining was applied to determine the severity of lung and pancreatic injury. ELISA kits were used to determine serum amylase and inflammatory cytokines levels. TUNEL staining was carried out to measure cell apoptosis. Western blotting was applied to analyze the related proteins of NLRP3 inflammasome and NF-κB pathways.FSTL-1 was significantly increased in the lung of SAP mice. Knockout of FSTL-1 ameliorated pancreatic injury, lung injury, inflammation and apoptosis in mice with SAP. Moreover, the protein levels of NLRP3, ASC, Caspase-1, p-p65 and p-IκBα were obviously reduced in the FSTL-1 KO+SAP group in comparison with SAP group, suggesting that inhibition of FSTL-1 repressed the activation of the NLRP3 inflammasome and NF-κB pathway.This study helps us understand the mechanism of FSTL-1 in SAPALI and might provide a potential new strategy for the treatment of SAPALI." @default.
- W4285613099 created "2022-07-16" @default.
- W4285613099 creator A5007293606 @default.
- W4285613099 creator A5018907559 @default.
- W4285613099 creator A5020186482 @default.
- W4285613099 creator A5090728786 @default.
- W4285613099 date "2022-01-01" @default.
- W4285613099 modified "2023-10-02" @default.
- W4285613099 title "Follistatin-like 1 ameliorates severe acute pancreatitis associated lung injury via inhibiting the activation of NLRP3 inflammasome and NF-κB pathway." @default.
- W4285613099 cites W1788396114 @default.
- W4285613099 cites W2024123957 @default.
- W4285613099 cites W2082581488 @default.
- W4285613099 cites W2100274868 @default.
- W4285613099 cites W2238225481 @default.
- W4285613099 cites W2415172433 @default.
- W4285613099 cites W2512483054 @default.
- W4285613099 cites W2543908829 @default.
- W4285613099 cites W2809325991 @default.
- W4285613099 cites W2968195988 @default.
- W4285613099 cites W2980525725 @default.
- W4285613099 cites W2995114612 @default.
- W4285613099 cites W3004744272 @default.
- W4285613099 cites W3014791637 @default.
- W4285613099 cites W3097431889 @default.
- W4285613099 cites W3120605752 @default.
- W4285613099 cites W3126118007 @default.
- W4285613099 cites W3126245516 @default.
- W4285613099 cites W3128602940 @default.
- W4285613099 cites W3133372929 @default.
- W4285613099 cites W3141608077 @default.
- W4285613099 cites W3153152368 @default.
- W4285613099 cites W3155293044 @default.
- W4285613099 cites W3164053816 @default.
- W4285613099 cites W3170212112 @default.
- W4285613099 cites W3176434644 @default.
- W4285613099 cites W3195280542 @default.
- W4285613099 cites W3199777989 @default.
- W4285613099 cites W3200495024 @default.
- W4285613099 cites W3201874620 @default.
- W4285613099 cites W3204193071 @default.
- W4285613099 cites W3204483221 @default.
- W4285613099 cites W3204794702 @default.
- W4285613099 cites W3204964353 @default.
- W4285613099 cites W3205204506 @default.
- W4285613099 cites W3206800966 @default.
- W4285613099 cites W3206936430 @default.
- W4285613099 cites W3207019623 @default.
- W4285613099 cites W3207337512 @default.
- W4285613099 cites W4226143307 @default.
- W4285613099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35836868" @default.
- W4285613099 hasPublicationYear "2022" @default.
- W4285613099 type Work @default.
- W4285613099 citedByCount "2" @default.
- W4285613099 countsByYear W42856130992023 @default.
- W4285613099 crossrefType "journal-article" @default.
- W4285613099 hasAuthorship W4285613099A5007293606 @default.
- W4285613099 hasAuthorship W4285613099A5018907559 @default.
- W4285613099 hasAuthorship W4285613099A5020186482 @default.
- W4285613099 hasAuthorship W4285613099A5090728786 @default.
- W4285613099 hasConcept C126322002 @default.
- W4285613099 hasConcept C139964883 @default.
- W4285613099 hasConcept C185592680 @default.
- W4285613099 hasConcept C190283241 @default.
- W4285613099 hasConcept C196795494 @default.
- W4285613099 hasConcept C203014093 @default.
- W4285613099 hasConcept C204232928 @default.
- W4285613099 hasConcept C2776670229 @default.
- W4285613099 hasConcept C2776914184 @default.
- W4285613099 hasConcept C2777209026 @default.
- W4285613099 hasConcept C2777714996 @default.
- W4285613099 hasConcept C2778831791 @default.
- W4285613099 hasConcept C2780471426 @default.
- W4285613099 hasConcept C55493867 @default.
- W4285613099 hasConcept C71924100 @default.
- W4285613099 hasConcept C98274493 @default.
- W4285613099 hasConceptScore W4285613099C126322002 @default.
- W4285613099 hasConceptScore W4285613099C139964883 @default.
- W4285613099 hasConceptScore W4285613099C185592680 @default.
- W4285613099 hasConceptScore W4285613099C190283241 @default.
- W4285613099 hasConceptScore W4285613099C196795494 @default.
- W4285613099 hasConceptScore W4285613099C203014093 @default.
- W4285613099 hasConceptScore W4285613099C204232928 @default.
- W4285613099 hasConceptScore W4285613099C2776670229 @default.
- W4285613099 hasConceptScore W4285613099C2776914184 @default.
- W4285613099 hasConceptScore W4285613099C2777209026 @default.
- W4285613099 hasConceptScore W4285613099C2777714996 @default.
- W4285613099 hasConceptScore W4285613099C2778831791 @default.
- W4285613099 hasConceptScore W4285613099C2780471426 @default.
- W4285613099 hasConceptScore W4285613099C55493867 @default.
- W4285613099 hasConceptScore W4285613099C71924100 @default.
- W4285613099 hasConceptScore W4285613099C98274493 @default.
- W4285613099 hasIssue "6" @default.
- W4285613099 hasLocation W42856130991 @default.
- W4285613099 hasOpenAccess W4285613099 @default.
- W4285613099 hasPrimaryLocation W42856130991 @default.
- W4285613099 hasRelatedWork W2001673434 @default.
- W4285613099 hasRelatedWork W2104441637 @default.
- W4285613099 hasRelatedWork W2129304025 @default.