Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285650143> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4285650143 endingPage "61" @default.
- W4285650143 startingPage "53" @default.
- W4285650143 abstract "Abstract Objectives The brain’s cholinergic system occupies a central role in normal cognition and age-related cognitive decline, including Alzheimer’s disease (AD). This study sought to investigate the role of antioxidant defense and cholinergic systems on rutin-induced antiamnesia in mice. Methods Rutin (1, 5, or 50 mg/kg, p.o.) or vehicle (10 ml/kg, p.o.) was administered for three consecutive days. One hour post-treatment on day 3, scopolamine (3 mg/kg, i.p) was given, 5 min post-scopolamine injection, open field, Y-maze, or Morris water maze (MWM) (five days consecutive training sessions) tasks was carried out. The mice were sacrificed on day 7 to assays for biomarkers of oxidative stress and cholinergic system. Results Scopolamine significantly reduced spontaneous alternation behavior in Y-maze and prolonged escape latency in MWM tasks when compared to vehicle-treated control indicative of working memory and spatial learning deficits. However, the pretreatment of mice with rutin (1, 5, or 50 mg/kg) prevented scopolamine-induced working memory and spatial learning impairments without affecting spontaneous locomotor activity. Scopolamine-induced nitrosative/oxidative stress and increased acetylcholinesterase activity in the prefrontal cortex and hippocampus were significantly attenuated by the pretreatment of mice with rutin. Conclusions rutin restored cognitive function in scopolamine-induced amnesia through enhancement of antioxidant defense and cholinergic systems." @default.
- W4285650143 created "2022-07-17" @default.
- W4285650143 creator A5011597049 @default.
- W4285650143 creator A5031716404 @default.
- W4285650143 creator A5062331185 @default.
- W4285650143 creator A5085647749 @default.
- W4285650143 date "2020-09-30" @default.
- W4285650143 modified "2023-10-17" @default.
- W4285650143 title "Rutin ameliorates scopolamine-induced learning and memory impairments through enhancement of antioxidant defense system and cholinergic signaling" @default.
- W4285650143 cites W1896970469 @default.
- W4285650143 cites W1968602836 @default.
- W4285650143 cites W1980539789 @default.
- W4285650143 cites W2001295612 @default.
- W4285650143 cites W2029102396 @default.
- W4285650143 cites W2048128157 @default.
- W4285650143 cites W2050552084 @default.
- W4285650143 cites W2056092147 @default.
- W4285650143 cites W2069060593 @default.
- W4285650143 cites W2070783401 @default.
- W4285650143 cites W2084593700 @default.
- W4285650143 cites W2085864038 @default.
- W4285650143 cites W2096795975 @default.
- W4285650143 cites W2130334989 @default.
- W4285650143 cites W2144742773 @default.
- W4285650143 cites W2261085470 @default.
- W4285650143 cites W2264611573 @default.
- W4285650143 cites W2468465528 @default.
- W4285650143 cites W2512537392 @default.
- W4285650143 cites W2553659869 @default.
- W4285650143 cites W2556630031 @default.
- W4285650143 cites W2568450381 @default.
- W4285650143 cites W2698460784 @default.
- W4285650143 cites W2743627045 @default.
- W4285650143 cites W2760928311 @default.
- W4285650143 cites W2805257646 @default.
- W4285650143 cites W2811390459 @default.
- W4285650143 cites W2912184659 @default.
- W4285650143 cites W2912602655 @default.
- W4285650143 doi "https://doi.org/10.1515/dmpt-2020-0118" @default.
- W4285650143 hasPublicationYear "2020" @default.
- W4285650143 type Work @default.
- W4285650143 citedByCount "2" @default.
- W4285650143 countsByYear W42856501432023 @default.
- W4285650143 crossrefType "journal-article" @default.
- W4285650143 hasAuthorship W4285650143A5011597049 @default.
- W4285650143 hasAuthorship W4285650143A5031716404 @default.
- W4285650143 hasAuthorship W4285650143A5062331185 @default.
- W4285650143 hasAuthorship W4285650143A5085647749 @default.
- W4285650143 hasConcept C134018914 @default.
- W4285650143 hasConcept C181199279 @default.
- W4285650143 hasConcept C185592680 @default.
- W4285650143 hasConcept C22885893 @default.
- W4285650143 hasConcept C2775847253 @default.
- W4285650143 hasConcept C2775963812 @default.
- W4285650143 hasConcept C2776151105 @default.
- W4285650143 hasConcept C2778004101 @default.
- W4285650143 hasConcept C2778816929 @default.
- W4285650143 hasConcept C2781161787 @default.
- W4285650143 hasConcept C44752575 @default.
- W4285650143 hasConcept C55493867 @default.
- W4285650143 hasConcept C71924100 @default.
- W4285650143 hasConcept C98274493 @default.
- W4285650143 hasConceptScore W4285650143C134018914 @default.
- W4285650143 hasConceptScore W4285650143C181199279 @default.
- W4285650143 hasConceptScore W4285650143C185592680 @default.
- W4285650143 hasConceptScore W4285650143C22885893 @default.
- W4285650143 hasConceptScore W4285650143C2775847253 @default.
- W4285650143 hasConceptScore W4285650143C2775963812 @default.
- W4285650143 hasConceptScore W4285650143C2776151105 @default.
- W4285650143 hasConceptScore W4285650143C2778004101 @default.
- W4285650143 hasConceptScore W4285650143C2778816929 @default.
- W4285650143 hasConceptScore W4285650143C2781161787 @default.
- W4285650143 hasConceptScore W4285650143C44752575 @default.
- W4285650143 hasConceptScore W4285650143C55493867 @default.
- W4285650143 hasConceptScore W4285650143C71924100 @default.
- W4285650143 hasConceptScore W4285650143C98274493 @default.
- W4285650143 hasIssue "1" @default.
- W4285650143 hasLocation W42856501431 @default.
- W4285650143 hasOpenAccess W4285650143 @default.
- W4285650143 hasPrimaryLocation W42856501431 @default.
- W4285650143 hasRelatedWork W1556362327 @default.
- W4285650143 hasRelatedWork W1978936854 @default.
- W4285650143 hasRelatedWork W2000662683 @default.
- W4285650143 hasRelatedWork W2041265148 @default.
- W4285650143 hasRelatedWork W2059612313 @default.
- W4285650143 hasRelatedWork W2090663532 @default.
- W4285650143 hasRelatedWork W2382512754 @default.
- W4285650143 hasRelatedWork W2794750913 @default.
- W4285650143 hasRelatedWork W3022122264 @default.
- W4285650143 hasRelatedWork W45690495 @default.
- W4285650143 hasVolume "36" @default.
- W4285650143 isParatext "false" @default.
- W4285650143 isRetracted "false" @default.
- W4285650143 workType "article" @default.