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- W4285673516 abstract "Abstract Background: Dust exposure has been reported as a risk factor of pulmonary disease, leading to alterations of segmental airways and parenchymal lungs. This study aims to investigate alterations of quantitative computed tomography (QCT)-based airway structural and functional metrics due to cement-dust exposure. Methods: To reduce confounding factors, subjects with normal spirometry without fibrosis, asthma and pneumonia histories were only selected, and a propensity score matching was applied to match age, sex, height, smoking status, and pack-years. Thus, from a larger data set (N=609), only 41 cement dust-exposed subjects were compared with 164 non-cement dust-exposed subjects. QCT imaging metrics of airway hydraulic diameter ( D h ), wall thickness (WT), and bifurcation angle ( θ ) were extracted at total lung capacity (TLC) and functional residual capacity (FRC), along with their deformation ratios between TLC and FRC. Results: In TLC scan, dust-exposed subjects showed a decrease of D h (airway narrowing) especially at lower-lobes ( p <0.05), an increase of WT (wall thickening) at all segmental airways ( p <0.05), and an alteration of θ at most of the central airways ( p <0.001) compared with non-dust-exposed subjects. Furthermore, dust-exposed subjects had smaller deformation ratios of WT at the segmental airways ( p <0.05) and θ at the right main bronchi and left main bronchi ( p <0.01), indicating airway stiffness. Conclusions: Dust-exposed subjects with normal spirometry demonstrated airway narrowing at lower-lobes, wall thickening at all segmental airways, a different bifurcation angle at central airways, and a loss of airway wall elasticity at lower-lobes. The airway structural alterations may indicate different airway pathophysiology due to cement dusts." @default.
- W4285673516 created "2022-07-17" @default.
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- W4285673516 date "2020-05-28" @default.
- W4285673516 modified "2023-09-30" @default.
- W4285673516 title "Quantitative CT-based Structural Alterations of Segmental Airways in Cement Dust-Exposed Subjects" @default.
- W4285673516 doi "https://doi.org/10.21203/rs.3.rs-16792/v2" @default.
- W4285673516 hasPublicationYear "2020" @default.
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