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• W4285677008 abstract "In this study, we report the bioorthogonal cleavage of physiologically stable methylene tetrazines bearing an ether or ester linkage in the presence of trans-cyclooctene. Based on this approach, molecules with phenol or carboxylic acid moieties were efficiently released in a controlled manner, which can be effectively applied in living cells. We expect this bioorthogonal cleavage approach can be applied to several biomedical applications, including the development of antibody–drug conjugates, pretargeted prodrug release, and protein activation." @default.
• W4285677008 created "2022-07-17" @default.
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• W4285677008 date "2022-07-17" @default.
• W4285677008 modified "2023-10-18" @default.
• W4285677008 title "Bioorthogonal Cleavage of Tetrazine-Caged Ethers and Esters Triggered by <i>trans</i>-Cyclooctene" @default.
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• W4285677008 doi "https://doi.org/10.1021/acs.orglett.2c01873" @default.
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