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• W4285677532 abstract "Abstract Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by a range of behavioral alterations including memory loss as well as cognitive and psychiatric symptoms. While there is growing evidence that cellular and molecular pathologies, such as the accumulation of amyloid beta (Aβ) plaques may contribute to AD, it remains unclear how this histopathology can give rise to such disparate behavioral deficits. One hypothesis for these diverse behavioral presentations is that Aβ accumulation has differential effects on neuronal circuits across brain regions, depending on the diverse neurophysiological properties and connections within and between the neurons in these different areas. To test this, we recorded from large neuronal populations in the dorsal and ventral CA1 regions of the hippocampus, areas that are known to be structurally and functionally diverse, in both APP/PS1 animals, a mouse model of Aβ pathology, and age-matched C57BL/6 controls. Although we found similar levels of Aβ pathology in the two subregions, populations of neurons in dorsal and ventral CA1 in APP/PS1 mice showed distinct signatures of disrupted neuronal activity as animals navigated a virtual reality environment. In dorsal CA1, pairwise correlations and entropy, a measure of the diversity of activity patterns, were decreased in the APP/PS1 mice. However, in ventral CA1, the opposite findings were observed; pair-wise correlations and entropy was increased in APP/PS1 mice relative to C57BL/6 controls. When we attempted to connect the microscopic features of population activity (the correlations) with the macroscopic features of the population code (the entropy) using a pairwise Ising model, we found that the models’ performance decreased in predicting dorsal CA1 activity but increased in predicting vCA1 activity in APP/PS1 mice, as compared to the C57BL/6 animals. Taken together, these findings suggest that Aβ pathology exerts distinct effects across different hippocampal regions. Our results suggest that the diverse behavioral deficits associated with AD and the cellular pathology that arises from Aβ accumulation may be mechanistically linked by studying the dynamics of neural activity within these diverse hippocampal circuits." @default.
• W4285677532 created "2022-07-17" @default.
• W4285677532 creator A5055258237 @default.
• W4285677532 creator A5072509657 @default.
• W4285677532 date "2022-07-16" @default.
• W4285677532 modified "2023-09-28" @default.
• W4285677532 title "Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of Aβ pathology" @default.
• W4285677532 cites W1805431826 @default.
• W4285677532 cites W1886575365 @default.
• W4285677532 cites W1934338242 @default.
• W4285677532 cites W1961971483 @default.
• W4285677532 cites W1964985810 @default.
• W4285677532 cites W1967823816 @default.
• W4285677532 cites W1971853827 @default.
• W4285677532 cites W1974098012 @default.
• W4285677532 cites W1974719406 @default.
• W4285677532 cites W1975141413 @default.
• W4285677532 cites W1975904615 @default.
• W4285677532 cites W1982785464 @default.
• W4285677532 cites W1983083547 @default.
• W4285677532 cites W1983784678 @default.
• W4285677532 cites W1993023011 @default.
• W4285677532 cites W1999653836 @default.
• W4285677532 cites W1999825136 @default.
• W4285677532 cites W2004852048 @default.
• W4285677532 cites W2010924378 @default.
• W4285677532 cites W2014898742 @default.
• W4285677532 cites W2015484447 @default.
• W4285677532 cites W2020436531 @default.
• W4285677532 cites W2021199403 @default.
• W4285677532 cites W2021510996 @default.
• W4285677532 cites W2024407413 @default.
• W4285677532 cites W2027122202 @default.
• W4285677532 cites W2027579198 @default.
• W4285677532 cites W2027704676 @default.
• W4285677532 cites W2029839050 @default.
• W4285677532 cites W2037129823 @default.
• W4285677532 cites W2038365936 @default.
• W4285677532 cites W2043297459 @default.
• W4285677532 cites W2045778298 @default.
• W4285677532 cites W2048685634 @default.
• W4285677532 cites W2051005796 @default.
• W4285677532 cites W2052515926 @default.
• W4285677532 cites W2052742260 @default.
• W4285677532 cites W2052918792 @default.
• W4285677532 cites W2054802697 @default.
• W4285677532 cites W2062605351 @default.
• W4285677532 cites W2062698830 @default.
• W4285677532 cites W2063808031 @default.
• W4285677532 cites W2067810163 @default.
• W4285677532 cites W2068084797 @default.
• W4285677532 cites W2070913242 @default.
• W4285677532 cites W2078917784 @default.
• W4285677532 cites W2081533023 @default.
• W4285677532 cites W2081826483 @default.
• W4285677532 cites W2082151254 @default.
• W4285677532 cites W2086671591 @default.
• W4285677532 cites W2086689153 @default.
• W4285677532 cites W2087298647 @default.
• W4285677532 cites W2087790185 @default.
• W4285677532 cites W2087965324 @default.
• W4285677532 cites W2088189569 @default.
• W4285677532 cites W2092764200 @default.
• W4285677532 cites W2103440561 @default.
• W4285677532 cites W2105847566 @default.
• W4285677532 cites W2109221379 @default.
• W4285677532 cites W2117509237 @default.
• W4285677532 cites W2119565218 @default.
• W4285677532 cites W2122065036 @default.
• W4285677532 cites W2122813545 @default.
• W4285677532 cites W2124214624 @default.
• W4285677532 cites W2131180711 @default.
• W4285677532 cites W2137408158 @default.
• W4285677532 cites W2138223008 @default.
• W4285677532 cites W2139092938 @default.
• W4285677532 cites W2139214514 @default.
• W4285677532 cites W2144057859 @default.
• W4285677532 cites W2145735461 @default.
• W4285677532 cites W2145805363 @default.
• W4285677532 cites W2146249493 @default.
• W4285677532 cites W2147101007 @default.
• W4285677532 cites W2147238273 @default.
• W4285677532 cites W2148606196 @default.
• W4285677532 cites W2150240029 @default.
• W4285677532 cites W2150746478 @default.
• W4285677532 cites W2156220037 @default.
• W4285677532 cites W2159838014 @default.
• W4285677532 cites W2166386587 @default.
• W4285677532 cites W2167822639 @default.
• W4285677532 cites W2169308121 @default.
• W4285677532 cites W2171148473 @default.
• W4285677532 cites W2171802424 @default.
• W4285677532 cites W2186584449 @default.
• W4285677532 cites W2239186975 @default.
• W4285677532 cites W2258879186 @default.
• W4285677532 cites W2343439038 @default.
• W4285677532 cites W2410446460 @default.
• W4285677532 cites W2465504877 @default.
• W4285677532 cites W2467288641 @default.
• W4285677532 cites W2474800249 @default.

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