Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285677595> ?p ?o ?g. }
- W4285677595 endingPage "29" @default.
- W4285677595 startingPage "1" @default.
- W4285677595 abstract "Esophageal squamous cell carcinoma (ESCC) is the most prevalent form of esophageal cancer in China and is closely associated with malignant biological characteristics and poor survival. Ferroptosis is a newly discovered iron-dependent mode of cell death that plays an important role in the biological behavior of ESCC cells. The clinical significance of ferroptosis-related long noncoding RNAs (FRLs) in ESCC remains unknown and warrants further research. The current study obtained RNA sequencing profiles and corresponding clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and FRLs were obtained through coexpression analysis. Consensus clustering was employed to divide the subjects into clusters, and immune-associated pathways were identified by functional analysis. The current study observed significant differences in the enrichment scores of immune cells among different clusters. Patients from TCGA-ESCC database were designated as the training cohort. A ten-FRL prediction signature was established using the least absolute shrinkage and selection operator Cox regression model and validated using the GEO cohort and our own independent validation database. Real-time quantitative polymerase chain reaction was used to verify the expression of the ten FRLs, and the ssGSEA analysis was employed to evaluate their function. In addition, the IMvigor database was used to assess the predictive value of the signature in terms of immunotherapeutic responses. Multivariate Cox and stratification analyses revealed that the ten-FRL signature was an independent predictor of the overall survival (OS). Patients with ESCC in the high-risk group displayed worse survival, a characteristic tumor immune microenvironment, and low immunotherapeutic benefits compared to those in the low-risk group. Collectively, the risk model established in this study could serve as a promising predictor of prognosis and immunotherapeutic response in patients with ESCC." @default.
- W4285677595 created "2022-07-17" @default.
- W4285677595 creator A5001062653 @default.
- W4285677595 creator A5002092628 @default.
- W4285677595 creator A5008587993 @default.
- W4285677595 creator A5008782343 @default.
- W4285677595 creator A5028179790 @default.
- W4285677595 creator A5037816091 @default.
- W4285677595 creator A5044491049 @default.
- W4285677595 creator A5053343934 @default.
- W4285677595 creator A5089282308 @default.
- W4285677595 date "2022-07-16" @default.
- W4285677595 modified "2023-10-01" @default.
- W4285677595 title "Ferroptosis-Related lncRNA Signature Correlates with the Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity of Esophageal Squamous Cell Carcinoma" @default.
- W4285677595 cites W1555903115 @default.
- W4285677595 cites W1975847255 @default.
- W4285677595 cites W1982488143 @default.
- W4285677595 cites W1985987855 @default.
- W4285677595 cites W2007288508 @default.
- W4285677595 cites W2022634173 @default.
- W4285677595 cites W2026387110 @default.
- W4285677595 cites W2027400517 @default.
- W4285677595 cites W2049553585 @default.
- W4285677595 cites W2069680436 @default.
- W4285677595 cites W2087897888 @default.
- W4285677595 cites W2135666910 @default.
- W4285677595 cites W2162207163 @default.
- W4285677595 cites W2175983554 @default.
- W4285677595 cites W2275201610 @default.
- W4285677595 cites W2279317198 @default.
- W4285677595 cites W2488521558 @default.
- W4285677595 cites W2509738156 @default.
- W4285677595 cites W2560367415 @default.
- W4285677595 cites W2560810570 @default.
- W4285677595 cites W2572174216 @default.
- W4285677595 cites W2591254177 @default.
- W4285677595 cites W2606811296 @default.
- W4285677595 cites W2735067056 @default.
- W4285677595 cites W2783665273 @default.
- W4285677595 cites W2785803176 @default.
- W4285677595 cites W2792272990 @default.
- W4285677595 cites W2797855256 @default.
- W4285677595 cites W2825407746 @default.
- W4285677595 cites W2891912856 @default.
- W4285677595 cites W2906488376 @default.
- W4285677595 cites W2916543168 @default.
- W4285677595 cites W2976652879 @default.
- W4285677595 cites W2981940937 @default.
- W4285677595 cites W2989680328 @default.
- W4285677595 cites W3003960907 @default.
- W4285677595 cites W3005722196 @default.
- W4285677595 cites W3008002744 @default.
- W4285677595 cites W3013967177 @default.
- W4285677595 cites W3018778542 @default.
- W4285677595 cites W3025003676 @default.
- W4285677595 cites W3044059477 @default.
- W4285677595 cites W3045029533 @default.
- W4285677595 cites W3054839585 @default.
- W4285677595 cites W3083768872 @default.
- W4285677595 cites W3084631824 @default.
- W4285677595 cites W3092384992 @default.
- W4285677595 cites W3102446661 @default.
- W4285677595 cites W3110813577 @default.
- W4285677595 cites W3112112590 @default.
- W4285677595 cites W3125007765 @default.
- W4285677595 cites W3133384087 @default.
- W4285677595 cites W3151596542 @default.
- W4285677595 cites W3158637626 @default.
- W4285677595 cites W3161442649 @default.
- W4285677595 cites W3165595905 @default.
- W4285677595 cites W3165780592 @default.
- W4285677595 cites W3170359222 @default.
- W4285677595 cites W3170540070 @default.
- W4285677595 cites W3179805832 @default.
- W4285677595 cites W3183078469 @default.
- W4285677595 cites W3184997779 @default.
- W4285677595 cites W3194902068 @default.
- W4285677595 cites W3196070940 @default.
- W4285677595 cites W3201346550 @default.
- W4285677595 cites W3208621807 @default.
- W4285677595 cites W3213498449 @default.
- W4285677595 doi "https://doi.org/10.1155/2022/7465880" @default.
- W4285677595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35903713" @default.
- W4285677595 hasPublicationYear "2022" @default.
- W4285677595 type Work @default.
- W4285677595 citedByCount "8" @default.
- W4285677595 countsByYear W42856775952022 @default.
- W4285677595 countsByYear W42856775952023 @default.
- W4285677595 crossrefType "journal-article" @default.
- W4285677595 hasAuthorship W4285677595A5001062653 @default.
- W4285677595 hasAuthorship W4285677595A5002092628 @default.
- W4285677595 hasAuthorship W4285677595A5008587993 @default.
- W4285677595 hasAuthorship W4285677595A5008782343 @default.
- W4285677595 hasAuthorship W4285677595A5028179790 @default.
- W4285677595 hasAuthorship W4285677595A5037816091 @default.
- W4285677595 hasAuthorship W4285677595A5044491049 @default.
- W4285677595 hasAuthorship W4285677595A5053343934 @default.
- W4285677595 hasAuthorship W4285677595A5089282308 @default.