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- W4285681446 endingPage "121089" @default.
- W4285681446 startingPage "121089" @default.
- W4285681446 abstract "• Different types of topoisomerases and their inhibitors are introduced. • Metal complexes of 17 metal ions are included in this review as topoisomerase inhibitors. • IC 50 values of 261 complexes tabulated. The topoisomerase family is a group of enzymes that orchestrate DNA topology and is required to uniform genetic makeup during replication, recombination, and transcription. Topoisomerase enzymes aid several DNA transactions through a complex series of DNA strand breaks and rejoining events, making them an important target for cancer treatment. Owing to its vital role in cellular processes, these enzymes are implicated as cellular targets for several therapeutically active anticancer agents. Metal complexes are more often used to inhibit topoisomerases. Metal complexes provide a three-dimensional framework exposing its functional groups that increase selectivity towards type I and type II topoisomerases. In this manner, biologically active ligands can have diverse biological activity and applications when complexed with active metals. This review focuses on the metal complexes that exhibit topoisomerase inhibition activity concerning their IC 50 values." @default.
- W4285681446 created "2022-07-17" @default.
- W4285681446 creator A5006893232 @default.
- W4285681446 creator A5034760600 @default.
- W4285681446 creator A5058421259 @default.
- W4285681446 date "2022-11-01" @default.
- W4285681446 modified "2023-10-02" @default.
- W4285681446 title "Metal complexes as topoisomerase inhibitors" @default.
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