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- W4285697098 abstract "The current study focused on the development of novel potentially active anti-microbial agents based on the benzimidazole-acetamide system. A novel series of various substituted benzimidazole- N- phenyl acetamides was synthesized through a feasible scheme characterized by IR, Proton nuclear magnetic resonance (1 HNMR), and MASS spectral methods. All the synthesized compounds were screened for antibacterial activity against two gram-positive strains: Staphylococcus aureus, Bacillus subtilis; four gramnegative strains: Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, and Klebsiella pneumonia; and anti-tubercular activity against mycobacterial strain: Mycobacterium tuberculosis. Among the 15 compounds (6a–6o) tested, three compounds, 6e, 6f, 6l, and 6m demonstrated high potency with MIC values ranging from 6.25–12.5μg/mL against both gram-positive and gram-negative strains. In addition, compounds 6e, 6f, and 6l displayed the highest anti-tubercular activity with a MIC value of 25μg/mL." @default.
- W4285697098 created "2022-07-18" @default.
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- W4285697098 date "2020-03-30" @default.
- W4285697098 modified "2023-10-15" @default.
- W4285697098 title "Novel Benzimidazole Acetamide Derivatives as Antibacterial and Anti-Tubercular Agents: Synthesis and Characterization" @default.
- W4285697098 doi "https://doi.org/10.25004/ijpsdr.2021.130310" @default.
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